Title

Key Roles of MiT Transcription Factors in Innate Immunity and Inflammation

UMMS Affiliation

Department of Microbiology and Physiological Systems; Program in Innate Immunity

Publication Date

2020-02-01

Document Type

Article

Disciplines

Immunology and Infectious Disease | Microbiology

Abstract

Microphthalmia/TFE (MiT) transcription factors (TFs), such as transcription factor EB (TFEB) and transcription factor E3 (TFE3), are emerging as key regulators of innate immunity and inflammation. Rapid progress in the field requires a focused update on the latest advances. Recent studies show that TFEB and TFE3 function in innate immune cells to regulate antibacterial and antiviral responses downstream of phagocytosis, interferon (IFN)-gamma, lipopolysaccharide (LPS), and adenosine receptors. Moreover, overexpression of TFEB or TFE3 can drive inflammation in vivo, such as in atherosclerosis, while in other scenarios they can perform anti-inflammatory functions. MiT factors may constitute potential therapeutic targets for a broad range of diseases; however, to harness their therapeutic potential, sophisticated ways to manipulate MiT factor activity safely and effectively must be developed.

Keywords

TFEB, TFE3, transcription, inflammation, innate immunity, infection

DOI of Published Version

10.1016/j.it.2019.12.003

Source

Trends Immunol. 2020 Feb;41(2):157-171. doi: 10.1016/j.it.2019.12.003. Epub 2020 Jan 17. Link to article on publisher's site

Journal/Book/Conference Title

Trends in immunology

Related Resources

Link to Article in PubMed

PubMed ID

31959514

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