Complex regulation and function of activation-induced cytidine deaminase
Department of Microbiology and Physiological Systems
Animals; B-Lymphocytes; Cytidine Deaminase; DNA, Superhelical; *Gene Expression Regulation, Enzymologic; Humans; Immunoglobulin Class Switching; Lymphocyte Activation; Mice; RNA Stability; Somatic Hypermutation, Immunoglobulin
Genetics and Genomics | Immunology and Infectious Disease
Activation-induced cytidine deaminase (AID) instigates mutations and DNA breaks in Ig genes that undergo somatic hypermutation and class switch recombination during B cell activation in response to immunization and infection. This review discusses how AID expression and activity are regulated, including recent discoveries of AID-interacting proteins that might recruit AID to Ig genes, and allow it to target both DNA strands. Also discussed is the accumulating evidence that AID binds to, mutates, and creates breaks at numerous non-Ig sites in the genome, which initiates cell transformation and malignancies.
DOI of Published Version
Trends Immunol. 2011 May;32(5):194-201. doi: 10.1016/j.it.2011.03.003. Link to article on publisher's site
Trends in immunology
Stavnezer, Janet, "Complex regulation and function of activation-induced cytidine deaminase" (2011). Microbiology and Physiological Systems Publications and Presentations. 6.