Title

Complex regulation and function of activation-induced cytidine deaminase

UMMS Affiliation

Department of Microbiology and Physiological Systems

Publication Date

2011-5

Document Type

Article

Subjects

Animals; B-Lymphocytes; Cytidine Deaminase; DNA, Superhelical; *Gene Expression Regulation, Enzymologic; Humans; Immunoglobulin Class Switching; Lymphocyte Activation; Mice; RNA Stability; Somatic Hypermutation, Immunoglobulin

Disciplines

Genetics and Genomics | Immunology and Infectious Disease

Abstract

Activation-induced cytidine deaminase (AID) instigates mutations and DNA breaks in Ig genes that undergo somatic hypermutation and class switch recombination during B cell activation in response to immunization and infection. This review discusses how AID expression and activity are regulated, including recent discoveries of AID-interacting proteins that might recruit AID to Ig genes, and allow it to target both DNA strands. Also discussed is the accumulating evidence that AID binds to, mutates, and creates breaks at numerous non-Ig sites in the genome, which initiates cell transformation and malignancies.

DOI of Published Version

10.1016/j.it.2011.03.003

Source

Trends Immunol. 2011 May;32(5):194-201. doi: 10.1016/j.it.2011.03.003. Link to article on publisher's site

Journal/Book/Conference Title

Trends in immunology

Related Resources

Link to Article in PubMed

PubMed ID

21493144

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