Title

Mode of action of beta-lactam antibiotics

UMMS Affiliation

Department of Molecular Genetics and Microbiology; Department of Microbiology and Physiological Systems

Publication Date

1985-01-01

Document Type

Article

Disciplines

Microbiology | Pharmacology | Physiology

Abstract

The action of 3-1actam antibiotics on sensitive bacteria can be regarded as a two-stage process. In the first stage, the antibiotics bincl to primary receptors, physically identified as membrane-associated penicillin-binding protein (PBP's). These proteins perform central roles in the cell cycle-related, morphogenetic synthesis of cell wall peptidoglycan. Inactivation of PBP's by bound antibiotic has immediate, biochemically definable effects on their function. The second stage encompasses the physiological effects on the sensitive cell initiated by this primary receptor-ligand interaction.

DOI of Published Version

10.1016/0163-7258(85)90062-2

Source

Pharmacol Ther. 1985;27(1):1-35.

Journal/Book/Conference Title

Pharmacology and therapeutics

Related Resources

Link to Article in PubMed

PubMed ID

3889939

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