Mode of action of beta-lactam antibiotics
Department of Molecular Genetics and Microbiology; Department of Microbiology and Physiological Systems
Microbiology | Pharmacology | Physiology
The action of 3-1actam antibiotics on sensitive bacteria can be regarded as a two-stage process. In the first stage, the antibiotics bincl to primary receptors, physically identified as membrane-associated penicillin-binding protein (PBP's). These proteins perform central roles in the cell cycle-related, morphogenetic synthesis of cell wall peptidoglycan. Inactivation of PBP's by bound antibiotic has immediate, biochemically definable effects on their function. The second stage encompasses the physiological effects on the sensitive cell initiated by this primary receptor-ligand interaction.
DOI of Published Version
Pharmacol Ther. 1985;27(1):1-35.
Pharmacology and therapeutics
Tipper DJ. (1985). Mode of action of beta-lactam antibiotics. Microbiology and Physiological Systems Publications. https://doi.org/10.1016/0163-7258(85)90062-2. Retrieved from https://escholarship.umassmed.edu/maps_pubs/34