Department of Molecular Genetics and Microbiology; Department of Microbiology and Physiological Systems
Bacteriology | Cellular and Molecular Physiology | Microbiology | Physiology
Proteus swarming is the rapid cyclical population migration across surfaces by elongated cells that hyperexpress flagellar and virulence genes. The mini-Tn5 transposon mutant mns2 was isolated as a tight nonswarming mutant that did not elongate or upregulate flagellar and hemolysin genes. Individual cell motility was retained but was reduced. The transposon had inserted in the gene encoding the global transcriptional regulator Lrp (leucine-responsive regulatory protein), expression of which was upregulated in differentiating swarm cells. Swarming was restored to the lrp mutant by artificial overexpression of the flhDC flagellar regulatory master operon. Lrp may be a key component in generating or relaying signals that are required for flagellation and swarming, possibly acting through the flhDC operon.
Proteus mirabilis, swarming
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Copyright © 1997, American Society for Microbiology. Publisher PDF posted as allowed by the publisher's copyright policy at https://journals.asm.org/content/copyright-transfer-and-supplemental-material-license-agreement-2017.
DOI of Published Version
J Bacteriol. 1997 Aug;179(15):4741-6. Link to article on publisher's site
Journal of bacteriology
Hay NA, Tipper DJ, Gygi D, Hughes C. (1997). A nonswarming mutant of Proteus mirabilis lacks the Lrp global transcriptional regulator. Microbiology and Physiological Systems Publications. https://doi.org/10.1128/jb.179.15.4741-4746.1997. Retrieved from https://escholarship.umassmed.edu/maps_pubs/25