UMMS Affiliation

Department of Microbiology and Physiological Systems; Division of Infectious Diseases and Immunology, Department of Medicine

Date

6-14-2016

Document Type

Article

Disciplines

Immunity | Immunology of Infectious Disease | Pathogenic Microbiology | Virology

Abstract

Zika virus has emerged as a severe health threat with a rapidly expanding range. The IFITM family of restriction factors inhibits the replication of a broad range of viruses, including the closely related flaviruses West Nile virus and dengue virus. Here, we show that IFITM1 and IFITM3 inhibit Zika virus infection early in the viral life cycle. Moreover, IFITM3 can prevent Zika-virus-induced cell death. These results suggest that strategies to boost the actions and/or levels of the IFITMs might be useful for inhibiting a broad range of emerging viruses.

Rights and Permissions

Citation: Cell Rep. 2016 Jun 14;15(11):2323-30. doi: 10.1016/j.celrep.2016.05.074. Epub 2016 Jun 3. Link to article on publisher's website

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Related Resources

Link to article in PubMed

Keywords

IFITM, IFITM1, IFITM3, Zika virus, flavivirus, host factors, interferon, intrinsic immunity

PubMed ID

27268505

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

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