Department of Microbiology and Physiological Systems; Division of Infectious Diseases and Immunology, Department of Medicine
Immunity | Immunology of Infectious Disease | Pathogenic Microbiology | Virology
Zika virus has emerged as a severe health threat with a rapidly expanding range. The IFITM family of restriction factors inhibits the replication of a broad range of viruses, including the closely related flaviruses West Nile virus and dengue virus. Here, we show that IFITM1 and IFITM3 inhibit Zika virus infection early in the viral life cycle. Moreover, IFITM3 can prevent Zika-virus-induced cell death. These results suggest that strategies to boost the actions and/or levels of the IFITMs might be useful for inhibiting a broad range of emerging viruses.
IFITM, IFITM1, IFITM3, Zika virus, flavivirus, host factors, interferon, intrinsic immunity
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This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
DOI of Published Version
Cell Rep. 2016 Jun 14;15(11):2323-30. doi: 10.1016/j.celrep.2016.05.074. Epub 2016 Jun 3. Link to article on publisher's website
Savidis, George; Perreira, Jill; Portmann, Jocelyn M.; Meraner, Paul; Guo, Zhiru; Green, Sharone; and Brass, Abraham L., "The IFITMs Inhibit Zika Virus Replication" (2016). Microbiology and Physiological Systems Publications and Presentations. 17.
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This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.