Title

Macrophages clean up: efferocytosis and microbial control

UMMS Affiliation

Department of Microbiology and Physiological Systems

Publication Date

2-1-2014

Document Type

Article

Subjects

Animals; Bacteria; Dendritic Cells; *Host-Pathogen Interactions; Humans; Leishmania; *Macrophages; Mice; Models, Immunological; Neutrophils; *Phagocytosis

Disciplines

Bacterial Infections and Mycoses | Immunoprophylaxis and Therapy | Microbiology | Pathogenic Microbiology

Abstract

Phagocytic leukocytes, predominantly macrophages, not only ingest and destroy invading pathogens, but are charged with clearing dead and dying host cells. The process of engulfing apoptotic cells is called efferocytosis and has long been appreciated for its role in the resolution of inflammation. New evidence is emerging that efferocytosis represents a double-edged sword in microbial immunity. Although efferocytosis of influenza and Mycobacterium tuberculosis-infected cells results in pathogen destruction, efferocytosis of Leishmania-infected neutrophils may promote infection. Understanding how macrophages, dendritic cells (DC) and neutrophils process pathogens encased within a dying cell could lead to the development of novel therapeutics that simultaneously suppress inflammation and promote pathogen clearance.

DOI of Published Version

10.1016/j.mib.2013.10.007

Source

Curr Opin Microbiol. 2014 Feb;17:17-23. doi: 10.1016/j.mib.2013.10.007. : Dec 5. Link to article on publisher's site. Epub 2013 Dec 5.

Journal/Book/Conference Title

Current opinion in microbiology

Related Resources

Link to Article in PubMed

PubMed ID

24581688

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