The Department of Microbiology and Physiological Systems (MaPS) was founded in 2010, and is the product of a merger between two departments, one focused on microbiology, genetics, and immunology, and the other focused on physiology. Capitalizing on the strength of the respective scientific research programs, the resulting department has strong and synergistic expertise in bacterial and viral pathogenesis, immunology, signal transduction, and fundamental cellular physiology. Current departmental research targets include viral and bacterial pathogens affecting the nervous, respiratory, and digestive systems. The mission of the new department is to address important biological questions broadly relevant to infectious disease and encompassing multiple levels of biological organization, including an understanding of pathogen effects on their target organ systems. This collection showcases the journal articles and other publications and presentations written by faculty and researchers of the Department of Microbiology and Physiological Systems. See earlier collections for selected Physiology and Molecular Genetics and Microbiology publications published before the departmental merger.

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Publications from 2020

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Probing Mechanisms of Transcription Elongation Through Cell-to-Cell Variability of RNA Polymerase, Zulfikar Ali, Sandeep Choubey, Dipjyoti Das, and Robert C. Brewster (Biophysical journal, 2020-04-07)

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Inherent regulatory asymmetry emanating from network architecture in a prevalent autoregulatory motif, Zulfikar Ali, Vinuselvi Parisutham, Sandeep Choubey, and Robert C. Brewster

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Skp, Cullin, F-box (SCF)-Met30 and SCF-Cdc4-Mediated Proteolysis of CENP-A Prevents Mislocalization of CENP-A for Chromosomal Stability in Budding Yeast, Wei-Chun Au, Richard E. Baker, and Munira A. Basrai

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Cell Cycle Associated Gene Expression Predicts Function in Mycobacteria, Aditya C. Bandekar

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Cell cycle-associated expression patterns predict gene function in mycobacteria [preprint], Aditya Bandekar, Sishir Subedi, Thomas Ioerger, and Christopher M. Sassetti

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Genetic Identification of Novel Mycobacterium tuberculosis Susceptibility and Survival Mechanisms During Antibiotic Treatment, Michelle M. Bellerose

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Distinct Bacterial Pathways Influence the Efficacy of Antibiotics against Mycobacterium tuberculosis, Michelle Bellerose, Megan K. Proulx, Clare M. Smith, Richard E. Baker, Thomas R. Ioerger, and Christopher M. Sassetti

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Acidic pH Triggers Lipid Mixing Mediated by Lassa Virus GP, Uriel Bulow, Ramesh Govindan, and James B. Munro

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Host immunity increases Mycobacterium tuberculosis reliance on cytochrome bd oxidase [preprint], Yi Cai, Eleni Jaecklein, Jared Mackenzie, Kadamba Papavinasasundaram, Michigan State University, Xinchun Chen, Africa Health Research Institute, and Christopher M. Sassetti

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Preventing Outbreaks through Interactive, Experiential Real-Life Simulations, Andres Colubri, Molly Kemball, Kian Sani, Chloe Boehm, Karen Mutch-Jones, Ben Fry, Todd Brown, and Pardis C. Sabeti

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Flexibility and constraint in preimplantation gene regulation in mouse [preprint], Colin C. Conine, Marina Krykbaeva, Lina Song, Robert C. Brewster, Nir Friedman, and Oliver J. Rando

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Comparisons of Antibody Populations in Different Pre-Fusion F VLP-Immunized Cotton Rat Dams and Their Offspring, Lori McGinnes Cullen, Marina S. Boukhvalova, Jorge C. G. Blanco, and Trudy G. Morrison

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Conformational changes in the Ebola virus membrane fusion machine induced by pH, Ca2+, and receptor binding, Dibyendu Kumar Das, Uriel Bulow, William E. Diehl, Natasha D. Durham, Fernando Senjobe, Kartik Chandran, Jeremy Luban, and James B. Munro

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Real-Time Analysis of Individual Ebola Virus Glycoproteins Reveals Pre-Fusion, Entry-Relevant Conformational Dynamics, Natasha D. Durham, Angela R. Howard, Ramesh Govindan, Fernando Senjobe, J. Maximilian Fels, William E. Diehl, Jeremy Luban, Kartik Chandran, and James B. Munro

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Dbf4-Dependent Kinase (DDK)-Mediated Proteolysis of CENP-A Prevents Mislocalization of CENP-A in Saccharomyces cerevisiae, Jessica R. Eisenstatt, Lars Boeckmann, Wei-Chun Au, Valerie Garcia, Levi Bursch, Josefina Ocampo, Michael Costanzo, Michael Weinreich, Robert A. Sclafani, Anastasia Baryshnikova, Chad L. Myers, Charles Boone, David J. Clark, Richard E. Baker, and Munira A. Basrai

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Precision Cas9 Genome Editing in vivo with All-in-one, Self-targeting AAV Vectors [preprint], Raed Ibraheim, Phillip W. L. Tai, Aamir Mir, Nida Javeed, Jiaming Wang, Tomas Rodriguez, Samantha J. Nelson, Eraj Khokhar, Esther Mintzer, Stacy Maitland​, Yueying Cao, Guangping Gao, and Erik J. Sontheimer

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Key Roles of MiT Transcription Factors in Innate Immunity and Inflammation, Javier E. Irazoqui

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Gp41-targeted antibodies restore infectivity of a fusion-deficient HIV-1 envelope glycoprotein, Vinita R. Joshi, Ruchi M. Newman, Melissa L. Pack, Karen A. Power, James B. Munro, Ken Okawa, Navid Madani, Joseph G. Sodroski, Aaron G. Schmidt, and Todd M. Allen

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Functional Genomics of Mammalian Innate Immunity, Michael C. Kiritsy

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A genome-wide screen in macrophages identifies new regulators of IFNγ-inducible MHCII that contribute to T cell activation [preprint], Michael C. Kiritsy, Michigan State University, Michigan State University, Michigan State University, Audrey E. Lord, M. Pontus A. Orning, Roland Elling, Katherine A. Fitzgerald, and Michigan State University

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CD11cHi monocyte-derived macrophages are a major cellular compartment infected by Mycobacterium tuberculosis, Jinhee Lee, Shayla Boyce, Jennifer Powers, Christina E. Baer, Christopher M. Sassetti, and Samuel M. Behar

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The DHODH Inhibitor PTC299 Arrests SARS-CoV-2 Replication and Suppresses Induction of Inflammatory Cytokines [preprint], Jeremy Luban, Caterina Strambio De Castilla, Yetao Wang, Allan Jacobson, and Stuart Peltz

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Scalable learning of interpretable rules for the dynamic microbiome domain [preprint], Venkata Suhas Maringanti, Vanni Bucci, and Georg K. Gerber

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A Developmental Analysis of Juxtavascular Microglia Dynamics and Interactions with the Vasculature, Erica Mondo, Shannon C. Becker, Amanda G. Kautzman, Martina Schifferer, Christina E. Baer, Jiapei Chen, Eric J. Huang, Mikael Simons, and Dorothy P. Schafer

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A developmental analysis of juxtavascular microglia dynamics and interactions with the vasculature [preprint], Erica Mondo, Shannon C. Becker, Amanda G. Kautzman, Martina Schifferer, Christina E. Baer, Jiapei Chen, Eric J. Huang, Mikael Simons, and Dorothy P. Schafer

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Mycobacterium tuberculosis evasion of Guanylate Binding Protein-mediated host defense in mice requires the ESX1 secretion system [preprint], Andrew J. Olive, Clare M. Smith, Christina E. Baer, Jörn Coers, and Christopher M. Sassetti

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Recovery of viable endocrine-specific cells and transcriptomes from human pancreatic islet-engrafted mice, Sambra D. Redick, Linda Leehy, Ann R. Rittenhouse, David M. Blodgett, Alan G. Derr, Alper Kucukural, Manuel Garber, Leonard D. Shultz, Dale L. Greiner, Jennifer P. Wang, David M. Harlan, Rita Bortell, and Agata Jurczyk

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Content and performance of the MiniMUGA genotyping array, a new tool to improve rigor and reproducibility in mouse research [preprint], John Sebastian Sigmon, Christopher M. Sassetti, Martin T. Ferris, Leonard McMillan, and Fernando Pardo-Manuel de Villena

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Biofilm Structure Promotes Coexistence of Phage-Resistant and Phage-Susceptible Bacteria, Emilia L. Simmons, Matthew C. Bond, Britt Koskella, Knut Drescher, Vanni Bucci, and Carey D. Nadell

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Natural Polymorphism of Mycobacterium tuberculosis and CD8 T Cell Immunity, Rujapak Sutiwisesak

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Molecular Assessment of Epiretinal Membrane: Activated Microglia, Oxidative Stress and Inflammation, Sushma Vishwakarma, Rishikesh Kumar Gupta, Saumya Jakati, Mudit Tyagi, Rajeev Reddy Pappuru, Keith Reddig, Gregory M. Hendricks, Michael R. Volkert, Hemant Khanna, Jay Chhablani, and Inderjeet Kaur

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Evaluation of IL-1 Blockade as an Adjunct to Linezolid Therapy for Tuberculosis in Mice and Macaques, Caylin G. Winchell, Bibhuti B. Mishra, Jia Yao Phuah, Samantha J. Nelson, Christopher M. Sassetti, and JoAnne L. Flynn

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Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant, Leonid Yurkovetskiy, Thomas Nyalile, Yetao Wang, William E. Diehl, Ann Dauphin, Claudia Carbone, Kristen Veinotte, Shawn B Egri, James B. Munro, Pardis C. Sabeti, Christos A. Kyratsous, Natalya V. Dudkina, Kuang Shen, and Jeremy Luban

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SARS-CoV-2 Spike protein variant D614G increases infectivity and retains sensitivity to antibodies that target the receptor binding domain [preprint], Leonid Yurkovetskiy, Thomas Nyalile, Yetao Wang, William E. Diehl, Ann Dauphin, Claudia Carbone, Kristen Veinotte, Shawn B. Egri, Pardis C. Sabeti, Christos Kyratsous, James B. Munro, Kuang Shen, and Jeremy Luban

Publications from 2019

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Comparative Pangenomics of the Mammalian Gut Commensal Bifidobacterium longum, Korin Albert, Asha Rani, and David Sela

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Regulatory asymmetry in the negative single-input module network motif: Role of network size, growth rate and binding affinity [preprint], Zulfikar Ali, Vinuselvi Parisutham, Sandeep Choubey, and Robert C. Brewster

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A Disintegrin and Metalloproteinase 9 Domain (ADAM9) Is a Major Susceptibility Factor in the Early Stages of Encephalomyocarditis Virus Infection, Lindsey E. Bazzone, Michael King, Christopher R. MacKay, Pyae Phyo Kyawe, Paul Meraner, Daniel Lindstrom, Joselyn Rojas-Quintero, Caroline A. Owen, Jennifer P. Wang, Abraham L. Brass, Evelyn A. Kurt-Jones, and Robert W. Finberg

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Common Variants in the Glycerol Kinase Gene Reduce Tuberculosis Drug Efficacy, Michelle M. Bellerose, Seung-Hun Baek, Chuan-Chin Huang, Caitlin E. Moss, Eun-Ik Koh, Megan K. Proulx, Clare M. Smith, Richard E. Baker, Jong Seok Lee, Seokyong Eum, Sung Jae Shin, Sang-Nae Cho, Megan Murray, and Christopher M. Sassetti

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A Persistence Detector for Metabolic Network Rewiring in an Animal, Jote T. Bulcha, Gabrielle E. Giese, Zulfikar Ali, Yong-Uk Lee, Melissa D. Walker, Amy D. Holdorf, L. Safak Yilmaz, Robert C. Brewster, and Albertha J. M. Walhout

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RE: Preventability of hospital onset bacterermia and fungemia: A pilot study of potential healthcare-associated infection outcome measure, by Dantes et al (2019), Anna M. Civitarese, Eric Ruggieri, Debbie Mack, Stephen O. Heard, Michael Mitchell, Craig M. Lilly, Karen E. Landry, Richard T. Ellison III, and J Matthias Walz

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Comparison of Immune Responses to Different Versions of VLP Associated Stabilized RSV Pre-Fusion F Protein, Lori M. Cullen, Madelyn R. Schmidt, Gretel M. Torres, Adam A. Capoferri, and Trudy G. Morrison

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Upper Gastrointestinal Perforations: A Possible Danger of Antibiotic Overuse, Vijaya Daniel, Stephanie Francalancia, Nili S. Amir, M. Didem Ayturk, Stacy B. Sanders, Jonathan R. Wisler, Courtney E. Collins, Doyle V. Ward, Catarina I. Kiefe, Beth A. McCormick, and Heena P. Santry

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OR14I1 is a receptor for the human cytomegalovirus pentameric complex and defines viral epithelial cell tropism, Xiaofei E, Paul Meraner, Ping Lu, Jill M. Perreira, Aaron M. Aker, William M. McDougall, Ronghua Zhuge, Gary C. Chan, Rachel M. Gerstein, Patrizia Caposio, Andrew D. Yurochko, Abraham L. Brass, and Timothy F. Kowalik

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Anti-drug Antibody Responses Impair Prophylaxis Mediated by AAV-Delivered HIV-1 Broadly Neutralizing Antibodies, Matthew R. Gardner, Ina Fetzer, Lisa M. Kattenhorn, Meredith E. Davis-Gardner, Amber S. Zhou, Barnett Alfant, Jesse A. Weber, Hema R. Kondur, Jose M. Martinez-Navio, Sebastian P. Fuchs, Ronald C. Desrosiers, Guangping Gao, Jeffrey D. Lifson, and Michael Farzan

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Alzheimer's Disease Microbiome Is Associated with Dysregulation of the Anti-Inflammatory P-Glycoprotein Pathway, John P. Haran, Shakti K. Bhattarai, Sage Foley, Protiva Dutta, Doyle V. Ward, Vanni Bucci, and Beth A. McCormick

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Frequent Loss of IRF2 in Cancers Leads to Immune Evasion through Decreased MHC Class I Antigen Presentation and Increased PD-L1 Expression, Barry Kriegsman, Pranitha Vangala, Benjamin J. Chen, Paul Meraner, Abraham L. Brass, Manuel Garber, and Kenneth L. Rock

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Viral Infection or IFN-alpha Alters Mitotic Spindle Orientation by Modulating Pericentrin Levels, William M. McDougall, Jill Perreira, Hui-Fang Hung, Anastassiia Vertii, E. Xiaofei, Wendy Zimmerman, Timothy F. Kowalik, Stephen J. Doxsey, and Abraham L. Brass

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A Novel PHOX/CD38/MCOLN1/TFEB Axis Important For Macrophage Activation During Bacterial Phagocytosis [preprint], Mehran Najibi, Joseph A. Moreau, Havisha H. Honwad, and Javier E. Irazoqui

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Evaluation of portable colposcopy and human papillomavirus testing for screening of cervical cancer in rural China, Haley Newman, Jilin Hu, Xiao Li, Jing He, Leslie Bradford, Songmei Shan, Xiaomei Wu, Bin Zhu, Wenyang Yang, Bingqin Fu, Baosheng Zhu, and Guangping Gao

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Differential skewing of donor-unrestricted and gammadelta T cell repertoires in tuberculosis-infected human lungs, Paul Ogongo, Adrie Jc. Steyn, Farina Karim, Kaylesh J. Dullabh, Ismael Awala, Rajhmun Madansein, Alasdair Leslie, and Samuel M. Behar

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Cognitive and Microbiome Impacts of Experimental Ancylostoma ceylanicum Hookworm Infections in Hamsters, Samuel C. Pan, Doyle V. Ward, Yunqiang Yin, Yan Hu, Elfawal A. Mostafa, Robert E. Clark, and Raffi V. Aroian

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The structure of the endogenous ESX-3 secretion system, Nicole Poweleit, Nadine Czudnochowski, Rachel Nakagawa, Donovan Trinidad, Kenan C. Murphy, Christopher M. Sassetti, and Oren S. Rosenberg

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Smooth muscle cell-specific TMEM16A deletion does not alter Ca2+ signaling, uterine contraction, gestation length or litter size in micedagger, Mingzi Qu, Ping Lu, Karl D. Bellve, Kevin E. Fogarty, Lawrence M. Lifshitz, Fangxiong Shi, and Ronghua ZhuGe

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Phosphorylation on PstP controls cell wall metabolism and antibiotic tolerance in Mycobacterium smegmatis [preprint], Farah Shamma, Kadamba Papavinasasundaram, Aditya Bandekar, Christopher M. Sassetti, and Cara C. Boutte

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Functionally Overlapping Variants Control Tuberculosis Susceptibility in Collaborative Cross Mice, Clare M. Smith, Megan K. Proulx, Rocky Lai, Michael C. Kiritsy, Timothy A. Bell, Pablo Hock, Fernando Pardo-Manuel de Villena, Martin T. Ferris, Richard E. Baker, Samuel M. Behar, and Christopher M. Sassetti

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Statistical analysis of variability in TnSeq data across conditions using zero-inflated negative binomial regression, Siddharth Subramaniyam, Michael A. DeJesus, Anisha Zaveri, Clare M. Smith, Richard E. Baker, Sabine Ehrt, Dirk Schnappinger, Christopher M. Sassetti, and Thomas R. Ioerger

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Interferon-induced transmembrane protein 3 blocks fusion of sensitive but not resistant viruses by partitioning into virus-carrying endosomes, Krishna C. Suddala, Christine C. Lee, Paul Meraner, Mariana Marin, Ruben M. Markosyan, Tanay M. Desai, Fredric S. Cohen, Abraham L. Brass, and Gregory B. Melikyan

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A Safe and Reliable Technique for CNS Delivery of AAV Vectors in the Cisterna Magna, Toloo Taghian, Miklos G. Marosfoi, Ajit S. Puri, Oguz Cataltepe, Robert M. King, Deborah Fernau, Ana Rita Batista, Terence R. Flotte, Diane McKenna-Yasek, Phillip W. L. Tai L, Neil Aronin, Matthew J. Gounis, Miguel Sena-Esteves, and Heather L. Gray-Edwards

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Gene Silencing With siRNA (RNA Interference): A New Therapeutic Option During Ex Vivo Machine Liver Perfusion Preservation, Max F. Thijssen, Isabel M. A. Bruggenwirth, Andrew R. Gillooly, Anastasia Khvorova, Timothy F. Kowalik, and Paulo N.A. Martins

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Gene Delivery to Nonhuman Primate Preimplantation Embryos Using Recombinant Adeno-Associated Virus, Dan Wang, Yuyu Niu, Lingzhi Ren, Yu Kang, Phillip W. L. Tai, Chenyang Si, Craig A. Mendonca, Hong Ma, Guangping Gao, and Weizhi Ji

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A Nutrition-Longevity Tradeoff Enforced by Innate Immunity, Khursheed A. Wani, Debanjan Goswamy, and Javier E. Irazoqui

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Nervous system control of intestinal host defense in C. elegans, Khursheed A. Wani, Debanjan Goswamy, and Javier E. Irazoqui

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Integration of genomic and clinical data augments surveillance of healthcare-acquired infections, Doyle V. Ward, Deborah Mack, Douglas J. Buell, Bruce A. Barton, Peter Lazar, Jomol Mathew, and Richard T. Ellison III

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Evaluation of IL-1 blockade as a host-directed therapy for tuberculosis in mice and macaques [preprint], Caylin G. Winchell, Bibhuti B. Mishra, University of Massachusetts Medical School, Samantha J. Nelson, Christopher M. Sassetti, and JoAnne L. Flynn

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TRAV1-2(+) CD8(+) T-cells including oligoconal expansions of MAIT cells are enriched in the airways in human tuberculosis, Emily B. Wong, Samuel M. Behar, and David M. Lewinsohn

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Circumventing cellular immunity by miR142-mediated regulation sufficiently supports rAAV-delivered OVA expression without activating humoral immunity, Yuanyuan Xiao, Manish Muhuri, Shaoyong Li, Guangchao Xu, Li Luo, Jia Li, Dan Wang, Qin Su, M. Abu Nahid, Christian Mueller, Phillip W. L. Tai, and Guangping Gao

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Bone-targeting AAV-mediated silencing of Schnurri-3 prevents bone loss in osteoporosis, Yeon-Suk Yang, Jun Xie, Dan Wang, Jung-Min Kim, Phillip W. L. Tai, Ellen M. Gravallese, Guangping Gao, and Jae-Hyuck Shim

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Curing hemophilia A by NHEJ-mediated ectopic F8 insertion in the mouse, Jian-Ping Zhang, Xin-Xin Cheng, Mei Zhao, Guo-Hua Li, Jing Xu, Feng Zhang, Meng-Di Yin, Fei-Ying Meng, Xin-Yue Dai, Ya-Wen Fu, Zhi-Xue Yang, Cameron Arakaki, Ruijun Jeanna. Su, Wei Wen, Wen-Tian Wang, Wanqiu Chen, Hannah Choi, Charles Wang, Guangping Gao, Lei Zhang, Tao Cheng, and Xiao-Bing Zhang

Publications from 2018

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The comparative genomics of Bifidobacterium callitrichos reflects dietary carbohydrate utilization within the common marmoset gut, Korin Albert, Asha Rani, and David A. Sela

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Draft Genome Sequence of Bifidobacterium longum UMA026, Isolated from Holstein Dairy Cow Feces, Korin Albert and David Sela

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Efficacy of a respiratory syncytial virus vaccine candidate in a maternal immunization model, Jorge C. G. Blanco, Lioubov M. Pletneva, Lori McGinnes Cullen, Raymonde O. Otoa, Mira C. Patel, Lurds R. Fernando, Marina S. Boukhvalova, and Trudy G. Morrison

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Nasopharyngeal Exposure to Streptococcus pneumoniae Induces Extended Age-Dependent Protection against Pulmonary Infection Mediated by Antibodies and CD138(+) Cells, Elsa N. Bou Ghanem, Nang H. Maung, Nalat Siwapornchai, Aaron E. Goodwin, Stacie Clark, Ernesto J. Munoz-Elias, Andrew Camilli, Rachel M. Gerstein, and John M. Leong

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A Comparative Study of Single and Dual Perfusion During End-ischemic Subnormothermic Liver Machine Preservation, Isabel M. A. Bruggenwirth, Carolina Moore, Paria Mahboub, Max F. Thijssen, Xiaofei E, Henri G. D. Leuvenink, Pranoti Mandrekar, Xiaofei Wang, Timothy F. Kowalik, Robert J. Porte, and Paulo N.A. Martins

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A Persistence Detector for Metabolic Network Rewiring in an Animal [preprint], Jote T. Bulcha, Gabrielle E. Giese, Zulfikar Ali, Yong-Uk Lee, Melissa D. Walker, Amy D. Holdorf, L. Safak Yilmaz, Robert C. Brewster, and Albertha J. M. Walhout

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Synonymous Mutations at the Beginning of the Influenza A Virus Hemagglutinin Gene Impact Experimental Fitness, Aneth S. Canale, Sergey V. Venev, Troy W. Whitfield, Daniel R. Caffrey, Wayne A. Marasco, Celia A. Schiffer, Timothy F. Kowalik, Jeffrey D. Jensen, Robert W. Finberg, Konstantin B. Zeldovich, Jennifer P. Wang, and Daniel N. Bolon

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Clostridium difficile Colonization and Infection in the Elderly and Associations with the Aging Intestinal Microbiome, John P. Haran

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The nursing home elder microbiome stability and associations with age, frailty, nutrition and physical location, John P. Haran, Vanni Bucci, Protiva Dutta, Doyle V. Ward, and Beth A. McCormick

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General decapping activators target different subsets of inefficiently translated mRNAs, Feng He, Alper Celik, Chan Wu, and Allan Jacobson

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Down-regulation of microRNA-203-3p initiates type 2 pathology during schistosome infection via elevation of interleukin-33, Xing He, Jun Xie, Yange Wang, Xiaobin Fan, Qin Su, Yue Sun, Nanhang Lei, Dongmei Zhang, Guangping Gao, and Weiqing Pan

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Dynamics of human protein kinases linked to drug selectivity [preprint], Dorothee Kern, Warintra Pitsawong, Brandeis University, Renee Otten, Roman V. Agafonov, Adelajda Zorba, Nadja Kern, Steffen Kutter, Gunther Kern, Ricardo A.P. Pádua, and Xavier Meniche

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Intestinal Epithelial Wnt Signaling Mediates Acetylcholine-Triggered Host Defense against Infection, Sid Ahmed Labed, Khursheed A. Wani, Sakthimala Jagadeesan, Abdul Hakkim, Mehran Najibi, and Javier E. Irazoqui

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cPLA2alpha-/- sympathetic neurons exhibit increased membrane excitability and loss of N-Type Ca2+ current inhibition by M1 muscarinic receptor signaling, Liwang Liu, Joseph V. Bonventre, and Ann R. Rittenhouse

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MicroRNA-96 Promotes Schistosomiasis Hepatic Fibrosis in Mice by Suppressing Smad7, Xufeng Luo, Dongmei Zhang, Jun Xie, Qin Su, Xing He, Ruipu Bai, Guangping Gao, and Weiqing Pan

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Transcriptome Profiling of Neovascularized Corneas Reveals miR-204 as a Multi-target Biotherapy Deliverable by rAAVs, Yi Lu, Phillip W. L. Tai, Jianzhong Ai, Dominic J. Gessler, Qin Su, Xieyi Yao, Qiang Zheng, Phillip D. Zamore, Xun Xu, and Guangping Gao

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ORBIT: a New Paradigm for Genetic Engineering of Mycobacterial Chromosomes, Kenan C. Murphy, Samantha J. Nelson, Subhalaxmi Nambi, Kadamba Papavinasasundaram, Christina E. Baer, and Christopher M. Sassetti

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ORBIT: a new paradigm for genetic engineering of mycobacterial chromosomes [preprint], Kenan C. Murphy, Samantha J. Nelson, Subhalaxmi Nambi, Kadamba Papavinasasundaram, Christina E. Baer, and Christopher M. Sassetti

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A new in vitro assay measuring direct interaction of nonsense suppressors with the eukaryotic protein synthesis machinery [preprint], Martin Y. Ng, Haibo Zhang, Amy Weil, Vijay Singh, Ryan M. Jamiolkowski, Alireza Baradaran-Heravi, Michel Roberge, Allan Jacobson, Ellen Welch, Yale Goldman, and Barry S. Cooperman

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N-terminal Sumoylation of Centromeric Histone H3 Variant Cse4 Regulates Its Proteolysis To Prevent Mislocalization to Non-centromeric Chromatin, Kentaro Ohkuni, Reuben Levy-Myers, Jack Warren, Wei-Chun Au, Yoshimitsu Takahashi, Richard E. Baker, and Munira A. Basrai

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SUMO-Targeted Ubiquitin Ligases (STUbLs) Reduce the Toxicity and Abnormal Transcriptional Activity Associated With a Mutant, Aggregation-Prone Fragment of Huntingtin, Kentaro Ohkuni, Nagesh Pasupala, Jennifer Peek, Grace Lauren Holloway, Gloria D. Sclar, Reuben Levy-Myers, Richard E. Baker, Munira A. Basrai, and Oliver Kerscher

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Tolerating the Unwelcome Guest; How the Host Withstands Persistent Mycobacterium tuberculosis, Andrew J. Olive and Christopher M. Sassetti

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Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death, M. Pontus A. Orning, Dan Wang, Kristian K. Starheim, Dmitry Ratner, Zachary Best, Bettina Lee, Alexandria Brooks, Shiyu Xia, Hao Wu, Michelle A. Kelliher, Scott B. Berger, Megan K. Proulx, Jon D. Goguen, Katherine A. Fitzgerald, and Egil Lien

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Inefficient Metabolism of the Human Milk Oligosaccharides Lacto-N-tetraose and Lacto-N-neotetraose Shifts Bifidobacterium longum subsp. infantis Physiology, Ezgi Ozcan and David Sela

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Gain of Function Analysis Reveals Non-Redundant Roles for the Yersinia pestis Type III Secretion System Effectors YopJ, YopT, and YpkA [preprint], Samantha G. Palace, Megan K. Proulx, Rose L. Szabady, and Jon D. Goguen

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Dynamics of human protein kinase Aurora A linked to drug selectivity, Warintra Pitsawong, Vanessa Buosi, Renee Otten, Roman V. Agafonov, Adelajda Zorba, Nadja Kern, Steffen Kutter, Gunther Kern, Ricardo Ap Padua, Xavier Meniche, and Dorothee Kern

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Mutations in influenza A virus neuraminidase and hemagglutinin confer resistance against a broadly neutralizing hemagglutinin stem antibody, Kristina L. Prachanronarong, Aneth S. Canale, Ping Liu, Mohan Somasundaran, Shurong Hou, Yu-Ping Poh, Thomas Han, Quan Zhu, Nicholas Renzette, Konstantin B. Zeldovich, Timothy F. Kowalik, Nese Kurt Yilmaz, Jeffrey D. Jensen, Daniel N. Bolon, Wayne A. Marasco, Robert W. Finberg, Celia A. Schiffer, and Jennifer P. Wang

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Modulation of CaV1.3b L-type calcium channels by M1 muscarinic receptors varies with CaVbeta subunit expression, Mandy L. Roberts-Crowley and Ann R. Rittenhouse

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On the Demographic and Selective Forces Shaping Patterns of Human Cytomegalovirus Variation within Hosts, Andrew M. Sackman, Susanne P. Pfeifer, Timothy F. Kowalik, and Jeffrey D. Jensen

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MicroRNA 122, Regulated by GRLH2, Protects Livers of Mice and Patients From Ethanol-Induced Liver Disease, Abhishek Satishchandran, Aditya Ambade, Sitara Rao, Ying-Chao Hsueh, Arvin Iracheta-Vellve, David Tornai, Patrick Lowe, Benedek Gyongyosi, Jia Li, Donna Catalano, Li Zhong, Karen Kodys, Jun Xie, Shashi Bala, Guangping Gao, and Gyongyi Szabo

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In vivo genome editing partially restores alpha1-antitrypsin in a murine model of AAT deficiency, Chun-Qing Song, Dan Wang, Tingting Jiang, Kevin O'Connor, Qiushi Tang, Lingling Cai, Xiangrui Li, Zhiping Weng, Hao Yin, Guangping Gao, Christian Mueller, Terence R. Flotte, and Wen Xue

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Intestinal P-glycoprotein exports endocannabinoids to prevent inflammation and maintain homeostasis, Rose L. Szabady, Christopher Louissaint, Anneke Lubben, Bailu Xie, Shaun Reeksting, Christine Tuohy, Zachary Demma, Sage Foley, Christina S. Faherty, Alejandro Llanos-Chea, Andrew J. Olive, Randall J. Mrsny, and Beth A. McCormick