The Department of Microbiology and Physiological Systems (MaPS) was founded in 2010, and is the product of a merger between two departments, one focused on microbiology, genetics, and immunology, and the other focused on physiology. Capitalizing on the strength of the respective scientific research programs, the resulting department has strong and synergistic expertise in bacterial and viral pathogenesis, immunology, signal transduction, and fundamental cellular physiology. Current departmental research targets include viral and bacterial pathogens affecting the nervous, respiratory, and digestive systems. The mission of the new department is to address important biological questions broadly relevant to infectious disease and encompassing multiple levels of biological organization, including an understanding of pathogen effects on their target organ systems. This collection showcases the journal articles and other publications and presentations written by faculty and researchers of the Department of Microbiology and Physiological Systems. See earlier collections for selected Physiology and Molecular Genetics and Microbiology publications published before the departmental merger.

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Publications from 2020

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Probing Mechanisms of Transcription Elongation Through Cell-to-Cell Variability of RNA Polymerase, Zulfikar Ali, Sandeep Choubey, Dipjyoti Das, and Robert C. Brewster (Biophysical journal, 2020-04-07)

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Skp, Cullin, F-box (SCF)-Met30 and SCF-Cdc4-Mediated Proteolysis of CENP-A Prevents Mislocalization of CENP-A for Chromosomal Stability in Budding Yeast, Wei-Chun Au, Richard E. Baker, and Munira A. Basrai

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Cell Cycle Associated Gene Expression Predicts Function in Mycobacteria, Aditya C. Bandekar

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Cell cycle-associated expression patterns predict gene function in mycobacteria, Aditya Bandekar, Sishir Subedi, Thomas Ioerger, and Christopher M. Sassetti

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Genetic Identification of Novel Mycobacterium tuberculosis Susceptibility and Survival Mechanisms During Antibiotic Treatment, Michelle M. Bellerose

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Flexibility and constraint in preimplantation gene regulation in mouse, Colin C. Conine, Marina Krykbaeva, Lina Song, Robert C. Brewster, Nir Friedman, and Oliver J. Rando

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Comparisons of Antibody Populations in Different Pre-Fusion F VLP-Immunized Cotton Rat Dams and Their Offspring, Lori McGinnes Cullen, Marina S. Boukhvalova, Jorge C. G. Blanco, and Trudy G. Morrison

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Conformational changes in the Ebola virus membrane fusion machine induced by pH, Ca2+, and receptor binding, Dibyendu Kumar Das, Uriel Bulow, William E. Diehl, Natasha D. Durham, Fernando Senjobe, Kartik Chandran, Jeremy Luban, and James B. Munro

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Real-Time Analysis of Individual Ebola Virus Glycoproteins Reveals Pre-Fusion, Entry-Relevant Conformational Dynamics, Natasha D. Durham, Angela R. Howard, Ramesh Govindan, Fernando Senjobe, J. Maximilian Fels, William E. Diehl, Jeremy Luban, Kartik Chandran, and James B. Munro

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Dbf4-Dependent Kinase (DDK)-Mediated Proteolysis of CENP-A Prevents Mislocalization of CENP-A in Saccharomyces cerevisiae, Jessica R. Eisenstatt, Lars Boeckmann, Wei-Chun Au, Valerie Garcia, Levi Bursch, Josefina Ocampo, Michael Costanzo, Michael Weinreich, Robert A. Sclafani, Anastasia Baryshnikova, Chad L. Myers, Charles Boone, David J. Clark, Richard E. Baker, and Munira A. Basrai

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Key Roles of MiT Transcription Factors in Innate Immunity and Inflammation, Javier E. Irazoqui

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A developmental analysis of juxtavascular microglia dynamics and interactions with the vasculature, Erica Mondo, Shannon C. Becker, Amanda G. Kautzman, Martina Schifferer, Christina E. Baer, Jiapei Chen, Eric J. Huang, Mikael Simons, and Dorothy P. Schafer

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Recovery of viable endocrine-specific cells and transcriptomes from human pancreatic islet-engrafted mice, Sambra D. Redick, Linda Leehy, Ann R. Rittenhouse, David M. Blodgett, Alan G. Derr, Alper Kucukural, Manuel Garber, Leonard D. Shultz, Dale L. Greiner, Jennifer P. Wang, David M. Harlan, Rita Bortell, and Agata Jurczyk

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Content and performance of the MiniMUGA genotyping array, a new tool to improve rigor and reproducibility in mouse research, John Sebastian Sigmon, Christopher M. Sassetti, Martin T. Ferris, Leonard McMillan, and Fernando Pardo-Manuel de Villena

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Natural Polymorphism of Mycobacterium tuberculosis and CD8 T Cell Immunity, Rujapak Sutiwisesak

Publications from 2019

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Comparative Pangenomics of the Mammalian Gut Commensal Bifidobacterium longum, Korin Albert, Asha Rani, and David Sela

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Regulatory asymmetry in the negative single-input module network motif: Role of network size, growth rate and binding affinity, Zulfikar Ali, Vinuselvi Parisutham, Sandeep Choubey, and Robert C. Brewster

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A Disintegrin and Metalloproteinase 9 Domain (ADAM9) Is a Major Susceptibility Factor in the Early Stages of Encephalomyocarditis Virus Infection, Lindsey E. Bazzone, Michael King, Christopher R. MacKay, Pyae Phyo Kyawe, Paul Meraner, Daniel Lindstrom, Joselyn Rojas-Quintero, Caroline A. Owen, Jennifer P. Wang, Abraham L. Brass, Evelyn A. Kurt-Jones, and Robert W. Finberg

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Common Variants in the Glycerol Kinase Gene Reduce Tuberculosis Drug Efficacy, Michelle M. Bellerose, Seung-Hun Baek, Chuan-Chin Huang, Caitlin E. Moss, Eun-Ik Koh, Megan K. Proulx, Clare M. Smith, Richard E. Baker, Jong Seok Lee, Seokyong Eum, Sung Jae Shin, Sang-Nae Cho, Megan Murray, and Christopher M. Sassetti

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A Persistence Detector for Metabolic Network Rewiring in an Animal, Jote T. Bulcha, Gabrielle E. Giese, Zulfikar Ali, Yong-Uk Lee, Melissa D. Walker, Amy D. Holdorf, L. Safak Yilmaz, Robert C. Brewster, and Albertha J. M. Walhout

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RE: Preventability of hospital onset bacterermia and fungemia: A pilot study of potential healthcare-associated infection outcome measure, by Dantes et al (2019), Anna M. Civitarese, Eric Ruggieri, Debbie Mack, Stephen O. Heard, Michael Mitchell, Craig M. Lilly, Karen E. Landry, Richard T. Ellison III, and J Matthias Walz

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Comparison of Immune Responses to Different Versions of VLP Associated Stabilized RSV Pre-Fusion F Protein, Lori M. Cullen, Madelyn R. Schmidt, Gretel M. Torres, Adam A. Capoferri, and Trudy G. Morrison

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Upper Gastrointestinal Perforations: A Possible Danger of Antibiotic Overuse, Vijaya Daniel, Stephanie Francalancia, Nili S. Amir, M. Didem Ayturk, Stacy B. Sanders, Jonathan R. Wisler, Courtney E. Collins, Doyle V. Ward, Catarina I. Kiefe, Beth A. McCormick, and Heena P. Santry

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OR14I1 is a receptor for the human cytomegalovirus pentameric complex and defines viral epithelial cell tropism, Xiaofei E, Paul Meraner, Ping Lu, Jill M. Perreira, Aaron M. Aker, William M. McDougall, Ronghua Zhuge, Gary C. Chan, Rachel M. Gerstein, Patrizia Caposio, Andrew D. Yurochko, Abraham L. Brass, and Timothy F. Kowalik

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Anti-drug Antibody Responses Impair Prophylaxis Mediated by AAV-Delivered HIV-1 Broadly Neutralizing Antibodies, Matthew R. Gardner, Ina Fetzer, Lisa M. Kattenhorn, Meredith E. Davis-Gardner, Amber S. Zhou, Barnett Alfant, Jesse A. Weber, Hema R. Kondur, Jose M. Martinez-Navio, Sebastian P. Fuchs, Ronald C. Desrosiers, Guangping Gao, Jeffrey D. Lifson, and Michael Farzan

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Alzheimer's Disease Microbiome Is Associated with Dysregulation of the Anti-Inflammatory P-Glycoprotein Pathway, John P. Haran, Shakti K. Bhattarai, Sage Foley, Protiva Dutta, Doyle V. Ward, Vanni Bucci, and Beth A. McCormick

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Frequent Loss of IRF2 in Cancers Leads to Immune Evasion through Decreased MHC Class I Antigen Presentation and Increased PD-L1 Expression, Barry Kriegsman, Pranitha Vangala, Benjamin J. Chen, Paul Meraner, Abraham L. Brass, Manuel Garber, and Kenneth L. Rock

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Viral Infection or IFN-alpha Alters Mitotic Spindle Orientation by Modulating Pericentrin Levels, William M. McDougall, Jill Perreira, Hui-Fang Hung, Anastassiia Vertii, E. Xiaofei, Wendy Zimmerman, Timothy F. Kowalik, Stephen J. Doxsey, and Abraham L. Brass

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A Novel PHOX/CD38/MCOLN1/TFEB Axis Important For Macrophage Activation During Bacterial Phagocytosis, Mehran Najibi, Joseph A. Moreau, Havisha H. Honwad, and Javier E. Irazoqui

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Evaluation of portable colposcopy and human papillomavirus testing for screening of cervical cancer in rural China, Haley Newman, Jilin Hu, Xiao Li, Jing He, Leslie Bradford, Songmei Shan, Xiaomei Wu, Bin Zhu, Wenyang Yang, Bingqin Fu, Baosheng Zhu, and Guangping Gao

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Differential skewing of donor-unrestricted and gammadelta T cell repertoires in tuberculosis-infected human lungs, Paul Ogongo, Adrie Jc. Steyn, Farina Karim, Kaylesh J. Dullabh, Ismael Awala, Rajhmun Madansein, Alasdair Leslie, and Samuel M. Behar

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Cognitive and Microbiome Impacts of Experimental Ancylostoma ceylanicum Hookworm Infections in Hamsters, Samuel C. Pan, Doyle V. Ward, Yunqiang Yin, Yan Hu, Elfawal A. Mostafa, Robert E. Clark, and Raffi V. Aroian

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The structure of the endogenous ESX-3 secretion system, Nicole Poweleit, Nadine Czudnochowski, Rachel Nakagawa, Donovan Trinidad, Kenan C. Murphy, Christopher M. Sassetti, and Oren S. Rosenberg

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Smooth muscle cell-specific TMEM16A deletion does not alter Ca2+ signaling, uterine contraction, gestation length or litter size in micedagger, Mingzi Qu, Ping Lu, Karl D. Bellve, Kevin E. Fogarty, Lawrence M. Lifshitz, Fangxiong Shi, and Ronghua ZhuGe

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Phosphorylation on PstP controls cell wall metabolism and antibiotic tolerance in Mycobacterium smegmatis, Farah Shamma, Kadamba Papavinasasundaram, Aditya Bandekar, Christopher M. Sassetti, and Cara C. Boutte

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Functionally Overlapping Variants Control Tuberculosis Susceptibility in Collaborative Cross Mice, Clare M. Smith, Megan K. Proulx, Rocky Lai, Michael C. Kiritsy, Timothy A. Bell, Pablo Hock, Fernando Pardo-Manuel de Villena, Martin T. Ferris, Richard E. Baker, Samuel M. Behar, and Christopher M. Sassetti

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Statistical analysis of variability in TnSeq data across conditions using zero-inflated negative binomial regression, Siddharth Subramaniyam, Michael A. DeJesus, Anisha Zaveri, Clare M. Smith, Richard E. Baker, Sabine Ehrt, Dirk Schnappinger, Christopher M. Sassetti, and Thomas R. Ioerger

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Interferon-induced transmembrane protein 3 blocks fusion of sensitive but not resistant viruses by partitioning into virus-carrying endosomes, Krishna C. Suddala, Christine C. Lee, Paul Meraner, Mariana Marin, Ruben M. Markosyan, Tanay M. Desai, Fredric S. Cohen, Abraham L. Brass, and Gregory B. Melikyan

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A Safe and Reliable Technique for CNS Delivery of AAV Vectors in the Cisterna Magna, Toloo Taghian, Miklos G. Marosfoi, Ajit S. Puri, Oguz Cataltepe, Robert M. King, Deborah Fernau, Ana Rita Batista, Terence R. Flotte, Diane McKenna-Yasek, Phillip W. L. Tai L, Neil Aronin, Matthew J. Gounis, Miguel Sena-Esteves, and Heather L. Gray-Edwards

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Gene Silencing With siRNA (RNA Interference): A New Therapeutic Option During Ex Vivo Machine Liver Perfusion Preservation, Max F. Thijssen, Isabel M. A. Bruggenwirth, Andrew R. Gillooly, Anastasia Khvorova, Timothy F. Kowalik, and Paulo N.A. Martins

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Gene Delivery to Nonhuman Primate Preimplantation Embryos Using Recombinant Adeno-Associated Virus, Dan Wang, Yuyu Niu, Lingzhi Ren, Yu Kang, Phillip W. L. Tai, Chenyang Si, Craig A. Mendonca, Hong Ma, Guangping Gao, and Weizhi Ji

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A Nutrition-Longevity Tradeoff Enforced by Innate Immunity, Khursheed A. Wani, Debanjan Goswamy, and Javier E. Irazoqui

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Nervous system control of intestinal host defense in C. elegans, Khursheed A. Wani, Debanjan Goswamy, and Javier E. Irazoqui

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Integration of genomic and clinical data augments surveillance of healthcare-acquired infections, Doyle V. Ward, Deborah Mack, Douglas J. Buell, Bruce A. Barton, Peter Lazar, Jomol Mathew, and Richard T. Ellison III

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Evaluation of IL-1 blockade as a host-directed therapy for tuberculosis in mice and macaques, Caylin G. Winchell, Bibhuti B. Mishra, University of Massachusetts Medical School, Samantha J. Nelson, Christopher M. Sassetti, and JoAnne L. Flynn

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TRAV1-2(+) CD8(+) T-cells including oligoconal expansions of MAIT cells are enriched in the airways in human tuberculosis, Emily B. Wong, Samuel M. Behar, and David M. Lewinsohn

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Circumventing cellular immunity by miR142-mediated regulation sufficiently supports rAAV-delivered OVA expression without activating humoral immunity, Yuanyuan Xiao, Manish Muhuri, Shaoyong Li, Guangchao Xu, Li Luo, Jia Li, Dan Wang, Qin Su, M. Abu Nahid, Christian Mueller, Phillip W. L. Tai, and Guangping Gao

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Bone-targeting AAV-mediated silencing of Schnurri-3 prevents bone loss in osteoporosis, Yeon-Suk Yang, Jun Xie, Dan Wang, Jung-Min Kim, Phillip W. L. Tai, Ellen M. Gravallese, Guangping Gao, and Jae-Hyuck Shim

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Curing hemophilia A by NHEJ-mediated ectopic F8 insertion in the mouse, Jian-Ping Zhang, Xin-Xin Cheng, Mei Zhao, Guo-Hua Li, Jing Xu, Feng Zhang, Meng-Di Yin, Fei-Ying Meng, Xin-Yue Dai, Ya-Wen Fu, Zhi-Xue Yang, Cameron Arakaki, Ruijun Jeanna. Su, Wei Wen, Wen-Tian Wang, Wanqiu Chen, Hannah Choi, Charles Wang, Guangping Gao, Lei Zhang, Tao Cheng, and Xiao-Bing Zhang

Publications from 2018

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The comparative genomics of Bifidobacterium callitrichos reflects dietary carbohydrate utilization within the common marmoset gut, Korin Albert, Asha Rani, and David A. Sela

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Draft Genome Sequence of Bifidobacterium longum UMA026, Isolated from Holstein Dairy Cow Feces, Korin Albert and David Sela

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Efficacy of a respiratory syncytial virus vaccine candidate in a maternal immunization model, Jorge C. G. Blanco, Lioubov M. Pletneva, Lori McGinnes Cullen, Raymonde O. Otoa, Mira C. Patel, Lurds R. Fernando, Marina S. Boukhvalova, and Trudy G. Morrison

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Nasopharyngeal Exposure to Streptococcus pneumoniae Induces Extended Age-Dependent Protection against Pulmonary Infection Mediated by Antibodies and CD138(+) Cells, Elsa N. Bou Ghanem, Nang H. Maung, Nalat Siwapornchai, Aaron E. Goodwin, Stacie Clark, Ernesto J. Munoz-Elias, Andrew Camilli, Rachel M. Gerstein, and John M. Leong

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A Comparative Study of Single and Dual Perfusion During End-ischemic Subnormothermic Liver Machine Preservation, Isabel M. A. Bruggenwirth, Carolina Moore, Paria Mahboub, Max F. Thijssen, Xiaofei E, Henri G. D. Leuvenink, Pranoti Mandrekar, Xiaofei Wang, Timothy F. Kowalik, Robert J. Porte, and Paulo N.A. Martins

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A Persistence Detector for Metabolic Network Rewiring in an Animal, Jote T. Bulcha, Gabrielle E. Giese, Zulfikar Ali, Yong-Uk Lee, Melissa D. Walker, Amy D. Holdorf, L. Safak Yilmaz, Robert C. Brewster, and Albertha J. M. Walhout

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Synonymous Mutations at the Beginning of the Influenza A Virus Hemagglutinin Gene Impact Experimental Fitness, Aneth S. Canale, Sergey V. Venev, Troy W. Whitfield, Daniel R. Caffrey, Wayne A. Marasco, Celia A. Schiffer, Timothy F. Kowalik, Jeffrey D. Jensen, Robert W. Finberg, Konstantin B. Zeldovich, Jennifer P. Wang, and Daniel N. Bolon

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Clostridium difficile Colonization and Infection in the Elderly and Associations with the Aging Intestinal Microbiome, John P. Haran

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The nursing home elder microbiome stability and associations with age, frailty, nutrition and physical location, John P. Haran, Vanni Bucci, Protiva Dutta, Doyle V. Ward, and Beth A. McCormick

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General decapping activators target different subsets of inefficiently translated mRNAs, Feng He, Alper Celik, Chan Wu, and Allan Jacobson

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Down-regulation of microRNA-203-3p initiates type 2 pathology during schistosome infection via elevation of interleukin-33, Xing He, Jun Xie, Yange Wang, Xiaobin Fan, Qin Su, Yue Sun, Nanhang Lei, Dongmei Zhang, Guangping Gao, and Weiqing Pan

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Dynamics of human protein kinases linked to drug selectivity, Dorothee Kern, Warintra Pitsawong, Brandeis University, Renee Otten, Roman V. Agafonov, Adelajda Zorba, Nadja Kern, Steffen Kutter, Gunther Kern, Ricardo A.P. Pádua, and Xavier Meniche

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Intestinal Epithelial Wnt Signaling Mediates Acetylcholine-Triggered Host Defense against Infection, Sid Ahmed Labed, Khursheed A. Wani, Sakthimala Jagadeesan, Abdul Hakkim, Mehran Najibi, and Javier E. Irazoqui

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cPLA2alpha-/- sympathetic neurons exhibit increased membrane excitability and loss of N-Type Ca2+ current inhibition by M1 muscarinic receptor signaling, Liwang Liu, Joseph V. Bonventre, and Ann R. Rittenhouse

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MicroRNA-96 Promotes Schistosomiasis Hepatic Fibrosis in Mice by Suppressing Smad7, Xufeng Luo, Dongmei Zhang, Jun Xie, Qin Su, Xing He, Ruipu Bai, Guangping Gao, and Weiqing Pan

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Transcriptome Profiling of Neovascularized Corneas Reveals miR-204 as a Multi-target Biotherapy Deliverable by rAAVs, Yi Lu, Phillip W. L. Tai, Jianzhong Ai, Dominic J. Gessler, Qin Su, Xieyi Yao, Qiang Zheng, Phillip D. Zamore, Xun Xu, and Guangping Gao

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ORBIT: a new paradigm for genetic engineering of mycobacterial chromosomes, Kenan C. Murphy, Samantha J. Nelson, Subhalaxmi Nambi, Kadamba Papavinasasundaram, Christina E. Baer, and Christopher M. Sassetti

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ORBIT: a New Paradigm for Genetic Engineering of Mycobacterial Chromosomes, Kenan C. Murphy, Samantha J. Nelson, Subhalaxmi Nambi, Kadamba Papavinasasundaram, Christina E. Baer, and Christopher M. Sassetti

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A new in vitro assay measuring direct interaction of nonsense suppressors with the eukaryotic protein synthesis machinery, Martin Y. Ng, Haibo Zhang, Amy Weil, Vijay Singh, Ryan M. Jamiolkowski, Alireza Baradaran-Heravi, Michel Roberge, Allan Jacobson, Ellen Welch, Yale Goldman, and Barry S. Cooperman

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N-terminal Sumoylation of Centromeric Histone H3 Variant Cse4 Regulates Its Proteolysis To Prevent Mislocalization to Non-centromeric Chromatin, Kentaro Ohkuni, Reuben Levy-Myers, Jack Warren, Wei-Chun Au, Yoshimitsu Takahashi, Richard E. Baker, and Munira A. Basrai

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SUMO-Targeted Ubiquitin Ligases (STUbLs) Reduce the Toxicity and Abnormal Transcriptional Activity Associated With a Mutant, Aggregation-Prone Fragment of Huntingtin, Kentaro Ohkuni, Nagesh Pasupala, Jennifer Peek, Grace Lauren Holloway, Gloria D. Sclar, Reuben Levy-Myers, Richard E. Baker, Munira A. Basrai, and Oliver Kerscher

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Tolerating the Unwelcome Guest; How the Host Withstands Persistent Mycobacterium tuberculosis, Andrew J. Olive and Christopher M. Sassetti

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Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death, M. Pontus A. Orning, Dan Wang, Kristian K. Starheim, Dmitry Ratner, Zachary Best, Bettina Lee, Alexandria Brooks, Shiyu Xia, Hao Wu, Michelle A. Kelliher, Scott B. Berger, Megan K. Proulx, Jon D. Goguen, Katherine A. Fitzgerald, and Egil Lien

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Inefficient Metabolism of the Human Milk Oligosaccharides Lacto-N-tetraose and Lacto-N-neotetraose Shifts Bifidobacterium longum subsp. infantis Physiology, Ezgi Ozcan and David Sela

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Gain of Function Analysis Reveals Non-Redundant Roles for the Yersinia pestis Type III Secretion System Effectors YopJ, YopT, and YpkA, Samantha G. Palace, Megan K. Proulx, Rose L. Szabady, and Jon D. Goguen

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Dynamics of human protein kinase Aurora A linked to drug selectivity, Warintra Pitsawong, Vanessa Buosi, Renee Otten, Roman V. Agafonov, Adelajda Zorba, Nadja Kern, Steffen Kutter, Gunther Kern, Ricardo Ap Padua, Xavier Meniche, and Dorothee Kern

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Mutations in influenza A virus neuraminidase and hemagglutinin confer resistance against a broadly neutralizing hemagglutinin stem antibody, Kristina L. Prachanronarong, Aneth S. Canale, Ping Liu, Mohan Somasundaran, Shurong Hou, Yu-Ping Poh, Thomas Han, Quan Zhu, Nicholas Renzette, Konstantin B. Zeldovich, Timothy F. Kowalik, Nese Kurt Yilmaz, Jeffrey D. Jensen, Daniel N. Bolon, Wayne A. Marasco, Robert W. Finberg, Celia A. Schiffer, and Jennifer P. Wang

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Modulation of CaV1.3b L-type calcium channels by M1 muscarinic receptors varies with CaVbeta subunit expression, Mandy L. Roberts-Crowley and Ann R. Rittenhouse

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On the Demographic and Selective Forces Shaping Patterns of Human Cytomegalovirus Variation within Hosts, Andrew M. Sackman, Susanne P. Pfeifer, Timothy F. Kowalik, and Jeffrey D. Jensen

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MicroRNA 122, Regulated by GRLH2, Protects Livers of Mice and Patients From Ethanol-Induced Liver Disease, Abhishek Satishchandran, Aditya Ambade, Sitara Rao, Ying-Chao Hsueh, Arvin Iracheta-Vellve, David Tornai, Patrick Lowe, Benedek Gyongyosi, Jia Li, Donna Catalano, Li Zhong, Karen Kodys, Jun Xie, Shashi Bala, Guangping Gao, and Gyongyi Szabo

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In vivo genome editing partially restores alpha1-antitrypsin in a murine model of AAT deficiency, Chun-Qing Song, Dan Wang, Tingting Jiang, Kevin O'Connor, Qiushi Tang, Lingling Cai, Xiangrui Li, Zhiping Weng, Hao Yin, Guangping Gao, Christian Mueller, Terence R. Flotte, and Wen Xue

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Intestinal P-glycoprotein exports endocannabinoids to prevent inflammation and maintain homeostasis, Rose L. Szabady, Christopher Louissaint, Anneke Lubben, Bailu Xie, Shaun Reeksting, Christine Tuohy, Zachary Demma, Sage Foley, Christina S. Faherty, Alejandro Llanos-Chea, Andrew J. Olive, Randall J. Mrsny, and Beth A. McCormick

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Adeno-associated Virus Genome Population Sequencing Achieves Full Vector Genome Resolution and Reveals Human-Vector Chimeras, Phillip W. L. Tai, Jun Xie, Kaiyuen Fong, Matthew Seetin, Cheryl Heiner, Qin Su, Michael Weiand, Daniella Wilmot, Maria L. Zapp, and Guangping Gao

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Cas9-mediated allelic exchange repairs compound heterozygous recessive mutations in mice, Dan Wang, Jia Li, Chun-Qing Song, Karen Tran, Haiwei Mou, Pei-Hsuan Wu, Phillip W. L. Tai L, Craig A. Mendonca, Lingzhi Ren, Blake Y. Wang, Qin Su, Dominic J. Gessler, Phillip D. Zamore, Wen Xue, and Guangping Gao

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A Rationally Engineered Capsid Variant of AAV9 for Systemic CNS-Directed and Peripheral Tissue-Detargeted Gene Delivery in Neonates, Dan Wang, Shaoyong Li, Dominic J. Gessler, Jun Xie, Li Zhong, Jia Li, Karen Tran, Kim Van Vliet, Lingzhi Ren, Qin Su, Ran He, Jason E. Goetzmann, Terence R. Flotte, Mavis Agbandje-McKenna, and Guangping Gao

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Adeno-Associated Virus Neutralizing Antibodies in Large Animals and Their Impact on Brain Intraparenchymal Gene Transfer, Dan Wang, Li Zhong, Mengxin Li, Jia Li, Karen Tran, Lingzhi Ren, Ran He, Jun Xie, Richard P. Moser, Cara Fraser, Tim Kuchel, Miguel Sena-Esteves, Terence R. Flotte, Neil Aronin, and Guangping Gao

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RNA Polymerase II Transcription Attenuation at the Yeast DNA Repair Gene, DEF1, Involves Sen1-Dependent and Polyadenylation Site-Dependent Termination, Courtney Whalen, Christine Tuohy, Thomas Tallo, James W. Kaufman, Claire Moore, and Jason N. Kuehner

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Antigen Specific CD4+ and CD8+ T Cell Recognition During Mycobacterium Tuberculosis Infection, Jason D. Yang

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Mycobacterium tuberculosis-specific CD4+ and CD8+ T cells differ in their capacity to recognize infected macrophages, Jason D. Yang, Daniel Mott, Rujapak Sutiwisesak, Yu-Jung Lu, Fiona Raso, Britni Stowell, Greg Hunter Babunovic, Jinhee Lee, Stephen M. Carpenter, Sing Sing Way, Sarah M. Fortune, and Samuel M. Behar

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Streamlined ex vivo and in vivo genome editing in mouse embryos using recombinant adeno-associated viruses, Yeonsoo Yoon, Dan Wang, Phillip W. L. Tai, Joy Riley, Guangping Gao, and Jaime A. Rivera-Perez

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Exploiting glycan topography for computational design of Env glycoprotein antigenicity, Wen-Han Yu, Peng Zhao, Monia Draghi, Claudia Arevalo, Christina B. Karsten, Todd J. Suscovich, Bronwyn Gunn, Hendrik Streeck, Abraham L. Brass, Michael Tiemeyer, Michael Seaman, John R. Mascola, Lance Wells, Douglas A. Lauffenburger, and Galit Alter

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Conserved mRNA-granule component Scd6 targets Dhh1 to repress translation initiation and activates Dcp2-mediated mRNA decay in vivo, Quira Zeidan, Feng He, Fan Zhang, Hongen Zhang, Allan Jacobson, and Alan G. Hinnebusch

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Substantial Increase in Compliance with Saturated Fatty Acid Intake Recommendations after One Year Following the American Heart Association Diet, Miaomiao Zhao, David E. Chiriboga, Barbara C. Olendzki, Bin Xie, Yawen Li, Lisa Jo McGonigal, Ana Maldonado-Contreras, and Yunsheng Ma

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The Role of Eukaryotic ABC-Transporters in Eliciting Neutrophil infiltration during Streptococcus pneumoniae infection, Andrew Zukauskas

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Transporters MRP1 and MRP2 Regulate Opposing Inflammatory Signals To Control Transepithelial Neutrophil Migration during Streptococcus pneumoniae Lung Infection, Andrew Zukauskas, Randall J. Mrsny, Paula Cortes Barrantes, Jerrold R. Turner, John M. Leong, and Beth A. McCormick

Publications from 2017

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Adeno-associated virus serotype rh.10 displays strong muscle tropism following intraperitoneal delivery, Jianzhong Ai, Jia Li, Dominic J. Gessler, Qin Su, Qiang Wei, Hong Li, and Guangping Gao

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Structural Determination of the Broadly Reactive Anti-IGHV1-69 Anti-idiotypic Antibody G6 and Its Idiotope, Yuval Avnir, Kristina L. Prachanronarong, Shurong Hou, Brendan J. Hilbert, Markus-Frederik Bohn, Timothy F. Kowalik, Robert W. Finberg, Jennifer P. Wang, Nese Kurt Yilmaz, Celia A. Schiffer, and Wayne A. Marasco

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"The Impact of Mycobacterium tuberculosis Immune Evasion on Protective Immunity: Implications for TB Vaccine Design" - Meeting report, Cesar Boggiano, Katrin Eichelberg, Lakshmi Ramachandra, Jaqueline Shea, Lalita Ramakrishnan, Samuel M. Behar, Joel D. Ernst, Steven A. Porcelli, Markus Maeurer, and Hardy Kornfeld

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Enteroaggregative Escherichia coli Adherence Fimbriae Drive Inflammatory Cell Recruitment via Interactions with Epithelial MUC1, Erik J. Boll, Jorge Ayala-Lujan, Rose L. Szabady, Christopher Louissaint, Rachel Z. Smith, Karen A. Krogfelt, James P. Nataro, Fernando Ruiz-Perez, and Beth A. McCormick

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Vaccine-elicited memory CD4+ T cell expansion is impaired in the lungs during tuberculosis, Stephen M. Carpenter, Jason D. Yang, Jinhee Lee, Palmira Barreira-Silva, and Samuel M. Behar

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mRNA Decay Pathways Use Translation Fidelity and Competing Decapping Complexes for Substrate Selection, Alper Celik