The Department of Microbiology and Physiological Systems (MaPS) was founded in 2010, and is the product of a merger between two departments, one focused on microbiology, genetics, and immunology, and the other focused on physiology. Capitalizing on the strength of the respective scientific research programs, the resulting department has strong and synergistic expertise in bacterial and viral pathogenesis, immunology, signal transduction, and fundamental cellular physiology. Current departmental research targets include viral and bacterial pathogens affecting the nervous, respiratory, and digestive systems. The mission of the new department is to address important biological questions broadly relevant to infectious disease and encompassing multiple levels of biological organization, including an understanding of pathogen effects on their target organ systems. This collection showcases the journal articles and other publications and presentations written by faculty and researchers of the Department of Microbiology and Physiological Systems. See earlier collections for selected Physiology and Molecular Genetics and Microbiology publications published before the departmental merger.

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Publications from 2021

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Two-Way Regulation of MmpL3 Expression Identifies and Validates Inhibitors of MmpL3 Function in Mycobacterium tuberculosis, Shipra Grover, Curtis A. Engelhart, Esther Perez-Herran, Wei Li, Katherine A. Abrahams, Kadamba Papavinasasundaram, James M. Bean, Christopher M. Sassetti, Alfonso Mendoza-Losana, Gurdyal S. Besra, Mary Jackson, and Dirk Schnappinger

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Quantifying the regulatory role of individual transcription factors in Escherichia coli [preprint], Sunil Guharajan, Shivani Chhabra, Vinuselvi Parisutham, and Robert C. Brewster

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Aging, Frailty, and the Microbiome - How Dysbiosis Influences Human Aging and Disease, John P. Haran and Beth A. McCormick

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Virtualized Clinical Studies to Assess the Natural History and Impact of Gut Microbiome Modulation in Non-Hospitalized Patients with Mild to Moderate COVID-19 a Randomized, Open-Label, Prospective Study with a Parallel Group Study Evaluating the Physiologic Effects of KB109 on Gut Microbiota Structure and Function: A Structured Summary of a Study Protocol for a Randomized Controlled Study [preprint], John P. Haran, Jose C. Pinero, Yan Zheng, Norma Alonzo Palma, and Mark Wingertzahn

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The high prevalence of Clostridioides difficile among nursing home elders associates with a dysbiotic microbiome, John P. Haran, Doyle V. Ward, Shakti K. Bhattarai, Ethan Loew, Protiva Dutta, Amanda Higgins, Beth A. McCormick, and Vanni Bucci

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The Mycobacterium tuberculosis transposon sequencing database (MtbTnDB): a large-scale guide to genetic conditional essentiality [preprint], Adrian Jinich, Anisha Zaveri, Michael A. DeJesus, Emanuel Flores-Bautista, Clare M. Smith, Christopher M. Sassetti, Jeremy M. Rock, Sabine Ehrt, Dirk Schnappinger, Thomas R. Ioerger, and Kyu Rhee

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Granulocytes act as a niche for Mycobacterium tuberculosis growth, Rustin R. Lovewell, Christina E. Baer, Bibhuti B. Mishra, Clare M. Smith, and Christopher M. Sassetti

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The DHODH inhibitor PTC299 arrests SARS-CoV-2 replication and suppresses induction of inflammatory cytokines, Jeremy Luban, Caterina Strambio-De-Castilla, Yetao Wang, Allan Jacobson, and Stuart W. Peltz

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CD4 T cell help prevents CD8 T cell exhaustion and promotes control of Mycobacterium tuberculosis infection [preprint], Yu-Jung Lu, Palmira Barreira-Silva, Shayla Boyce, Jennifer Powers, Kelly Cavallo, and Samuel M. Behar

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Overcoming innate immune barriers that impede AAV gene therapy vectors, Manish Muhuri, Yukiko Maeda Garrison, Hong Ma, Sanjay Ram, Katherine A. Fitzgerald, Phillip W. L. Tai, and Guangping Gao

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CNBP, REL, and BHLHE40 variants are associated with IL-12 and IL-10 responses and tuberculosis risk [preprint], Javeed A. Shah, Christopher M. Sassetti, and Katherine A. Fitzgerald

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The Intestinal and Oral Microbiomes Are Robust Predictors of COVID-19 Severity the Main Predictor of COVID-19-related Fatality [preprint], Doyle V. Ward, Shakti Bhattarai, Mayra Rojas-Correa, Ayan Purkayastha, Devon Holler, Ming Da Qu, William G. Mitchell, Jason D. Yang, Samuel Fountain, Abigail Zeamer, Catherine Forconi, Gavin Fujimori, Boaz Odwar, Caitlin Cawley, Beth A. McCormick, Ann M. Moormann, Mireya Wessolossky, Vanni Bucci, and Ana Maldonado-Contreras

Publications from 2020

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Probing Mechanisms of Transcription Elongation Through Cell-to-Cell Variability of RNA Polymerase, Zulfikar Ali, Sandeep Choubey, Dipjyoti Das, and Robert C. Brewster (Biophysical journal, 2020-04-07)

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Inherent regulatory asymmetry emanating from network architecture in a prevalent autoregulatory motif, Zulfikar Ali, Vinuselvi Parisutham, Sandeep Choubey, and Robert C. Brewster

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Skp, Cullin, F-box (SCF)-Met30 and SCF-Cdc4-Mediated Proteolysis of CENP-A Prevents Mislocalization of CENP-A for Chromosomal Stability in Budding Yeast, Wei-Chun Au, Richard E. Baker, and Munira A. Basrai

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Cell Cycle Associated Gene Expression Predicts Function in Mycobacteria, Aditya C. Bandekar

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Cell cycle-associated expression patterns predict gene function in mycobacteria [preprint], Aditya Bandekar, Sishir Subedi, Thomas Ioerger, and Christopher M. Sassetti

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Genetic Identification of Novel Mycobacterium tuberculosis Susceptibility and Survival Mechanisms During Antibiotic Treatment, Michelle M. Bellerose

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Distinct Bacterial Pathways Influence the Efficacy of Antibiotics against Mycobacterium tuberculosis, Michelle Bellerose, Megan K. Proulx, Clare M. Smith, Richard E. Baker, Thomas R. Ioerger, and Christopher M. Sassetti

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Docosanoic acid conjugation to siRNA enables functional and safe delivery to skeletal and cardiac muscles, Annabelle Biscans, Jillian Caiazzi, Nicholas McHugh, Vignesh Hariharan, Manish Muhuri, and Anastasia Khvorova

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Acidic pH Triggers Lipid Mixing Mediated by Lassa Virus GP, Uriel Bulow, Ramesh Govindan, and James B. Munro

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Host immunity increases Mycobacterium tuberculosis reliance on cytochrome bd oxidase [preprint], Yi Cai, Eleni Jaecklein, Jared Mackenzie, Kadamba Papavinasasundaram, Michigan State University, Xinchun Chen, Africa Health Research Institute, and Christopher M. Sassetti

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ORAN: A meta-modeling platform to drive real-life and online outbreak simulations, Andres Colubri

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Preventing Outbreaks through Interactive, Experiential Real-Life Simulations, Andres Colubri, Molly Kemball, Kian Sani, Chloe Boehm, Karen Mutch-Jones, Ben Fry, Todd Brown, and Pardis C. Sabeti

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Flexibility and constraint in preimplantation gene regulation in mouse [preprint], Colin C. Conine, Marina Krykbaeva, Lina Song, Robert C. Brewster, Nir Friedman, and Oliver J. Rando

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Comparisons of Antibody Populations in Different Pre-Fusion F VLP-Immunized Cotton Rat Dams and Their Offspring, Lori McGinnes Cullen, Marina S. Boukhvalova, Jorge C. G. Blanco, and Trudy G. Morrison

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Conformational changes in the Ebola virus membrane fusion machine induced by pH, Ca2+, and receptor binding, Dibyendu Kumar Das, Uriel Bulow, William E. Diehl, Natasha D. Durham, Fernando Senjobe, Kartik Chandran, Jeremy Luban, and James B. Munro

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Bifidobacterium infantis Metabolizes 2'Fucosyllactose-Derived and Free Fucose Through a Common Catabolic Pathway Resulting in 1,2-Propanediol Secretion, Liv R. Dedon, Ezgi Ozcan, Asha Rani, and David A. Sela

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Real-Time Analysis of Individual Ebola Virus Glycoproteins Reveals Pre-Fusion, Entry-Relevant Conformational Dynamics, Natasha D. Durham, Angela R. Howard, Ramesh Govindan, Fernando Senjobe, J. Maximilian Fels, William E. Diehl, Jeremy Luban, Kartik Chandran, and James B. Munro

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Dbf4-Dependent Kinase (DDK)-Mediated Proteolysis of CENP-A Prevents Mislocalization of CENP-A in Saccharomyces cerevisiae, Jessica R. Eisenstatt, Lars Boeckmann, Wei-Chun Au, Valerie Garcia, Levi Bursch, Josefina Ocampo, Michael Costanzo, Michael Weinreich, Robert A. Sclafani, Anastasia Baryshnikova, Chad L. Myers, Charles Boone, David J. Clark, Richard E. Baker, and Munira A. Basrai

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Single-cell profiling of tuberculosis lung granulomas reveals functional lymphocyte signatures of bacterial control [preprint], Hannah P. Gideon, Samuel M. Behar, and Alex Shalek

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Single-cell profiling of tuberculosis lung granulomas reveals functional lymphocyte signatures of bacterial control [preprint], Hannah P. Gideon, Samuel M. Behar, and Alex Shalek

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Analysis of Recombinant Adeno-Associated Virus (rAAV) Sample Morphology Using Negative Staining and High-Resolution Electron Microscopy, Gregory M. Hendricks, Miguel Sena-Esteves, and Guangping Gao

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Precision Cas9 Genome Editing in vivo with All-in-one, Self-targeting AAV Vectors [preprint], Raed Ibraheim, Phillip W. L. Tai, Aamir Mir, Nida Javeed, Jiaming Wang, Tomas Rodriguez, Samantha J. Nelson, Eraj Khokhar, Esther Mintzer, Stacy Maitland​, Yueying Cao, Guangping Gao, and Erik J. Sontheimer

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Key Roles of MiT Transcription Factors in Innate Immunity and Inflammation, Javier E. Irazoqui

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Imposed mutational meltdown as an antiviral strategy, Jeffrey D. Jensen, Ryan A. Stikeleather, Timothy F. Kowalik, and Michael Lynch

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Gp41-targeted antibodies restore infectivity of a fusion-deficient HIV-1 envelope glycoprotein, Vinita R. Joshi, Ruchi M. Newman, Melissa L. Pack, Karen A. Power, James B. Munro, Ken Okawa, Navid Madani, Joseph G. Sodroski, Aaron G. Schmidt, and Todd M. Allen

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M. tuberculosis Reprograms Hematopoietic Stem Cells to Limit Myelopoiesis and Impair Trained Immunity, Nargis Khan, Christopher M. Sassetti, and Maziar Divangahi

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Functional Genomics of Mammalian Innate Immunity, Michael C. Kiritsy

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A genome-wide screen in macrophages identifies new regulators of IFNγ-inducible MHCII that contribute to T cell activation [preprint], Michael C. Kiritsy, Michigan State University, Michigan State University, Michigan State University, Audrey E. Lord, M. Pontus A. Orning, Roland Elling, Katherine A. Fitzgerald, and Michigan State University

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Mitochondrial respiration contributes to the interferon gamma response in antigen presenting cells [preprint], Michael C. Kiritsy, Daniel Mott, Samuel M. Behar, Christopher M. Sassetti, and Andrew J. Olive

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CD11cHi monocyte-derived macrophages are a major cellular compartment infected by Mycobacterium tuberculosis, Jinhee Lee, Shayla Boyce, Jennifer Powers, Christina E. Baer, Christopher M. Sassetti, and Samuel M. Behar

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A C. elegans neuron both promotes and suppresses motor behavior to fine tune motor output [preprint], Zhaoyu Li, Jiejun Zhou, Khursheed A. Wani, Teng Yu, Elizabeth A. Ronan, University of Michigan - Ann Arbor, Jianfeng Liu, and X.Z. Shawn Xu

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The DHODH Inhibitor PTC299 Arrests SARS-CoV-2 Replication and Suppresses Induction of Inflammatory Cytokines [preprint], Jeremy Luban, Caterina Strambio De Castilla, Yetao Wang, Allan Jacobson, and Stuart Peltz

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Dysbiosis in a canine model of human fistulizing Crohn's disease, Ana Maldonado-Contreras, Lluis Ferrer, Caitlin Cawley, Sarah Crain, Shakti Bhattarai, Juan Toscano, Doyle V. Ward, and Andrew Hoffman

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Transcriptome-wide investigation of stop codon readthrough in Saccharomyces cerevisiae [preprint], Kotchaphorn Mangkalaphiban, Feng He, Robin Ganesan, Chan Wu, Richard E. Baker, and Allan Jacobson

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Transcriptome-wide investigation of stop codon readthrough in Saccharomyces cerevisiae [poster], Kotchaphorn Mangkalaphiban, Feng He, Robin Ganesan, Chan Wu, Richard E. Baker, and Allan S. Jacobson

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Scalable learning of interpretable rules for the dynamic microbiome domain [preprint], Venkata Suhas Maringanti, Vanni Bucci, and Georg K. Gerber

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A Developmental Analysis of Juxtavascular Microglia Dynamics and Interactions with the Vasculature, Erica Mondo, Shannon C. Becker, Amanda G. Kautzman, Martina Schifferer, Christina E. Baer, Jiapei Chen, Eric J. Huang, Mikael Simons, and Dorothy P. Schafer

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A developmental analysis of juxtavascular microglia dynamics and interactions with the vasculature [preprint], Erica Mondo, Shannon C. Becker, Amanda G. Kautzman, Martina Schifferer, Christina E. Baer, Jiapei Chen, Eric J. Huang, Mikael Simons, and Dorothy P. Schafer

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Is smaller better? Vaccine targeting recombinant receptor-binding domain might hold the key for mass production of effective prophylactics to fight the COVID-19 pandemic, Manish Muhuri and Guangping Gao

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Mycobacterium tuberculosis evasion of Guanylate Binding Protein-mediated host defense in mice requires the ESX1 secretion system [preprint], Andrew J. Olive, Clare M. Smith, Christina E. Baer, Jörn Coers, and Christopher M. Sassetti

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Recovery of viable endocrine-specific cells and transcriptomes from human pancreatic islet-engrafted mice, Sambra D. Redick, Linda Leehy, Ann R. Rittenhouse, David M. Blodgett, Alan G. Derr, Alper Kucukural, Manuel Garber, Leonard D. Shultz, Dale L. Greiner, Jennifer P. Wang, David M. Harlan, Rita Bortell, and Agata Jurczyk

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Containing the Spread of Infectious Disease on College Campuses [preprint], Mirai Shah, Gabrielle Ferra, Susan Fitzgerald, Paul J. Barreira, Pardis C. Sabeti, and Andres Colubri

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Metabolic interactions in microbial communities, Elizabeth A. Shank

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Transparent soil microcosms for live-cell imaging and non-destructive stable isotope probing of soil microorganisms, Kriti Sharma, Marton Palatinszky, Georgi Nikolov, David Berry, and Elizabeth A. Shank

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Content and performance of the MiniMUGA genotyping array, a new tool to improve rigor and reproducibility in mouse research [preprint], John Sebastian Sigmon, Christopher M. Sassetti, Clare M. Smith, Martin T. Ferris, Leonard McMillan, and Fernando Pardo-Manuel de Villena

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Content and Performance of the MiniMUGA Genotyping Array: A New Tool To Improve Rigor and Reproducibility in Mouse Research, John Sebastian Sigmon, Christopher M. Sassetti, Clare M. Smith, and Fernando Pardo Manuel de Villena

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Biofilm Structure Promotes Coexistence of Phage-Resistant and Phage-Susceptible Bacteria, Emilia L. Simmons, Matthew C. Bond, Britt Koskella, Knut Drescher, Vanni Bucci, and Carey D. Nadell

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Host-pathogen genetic interactions underlie tuberculosis susceptibility in genetically diverse mice [preprint], Clare M. Smith, Richard E. Baker, Megan K. Proulx, Bibhuti B. Mishra, Jarukit E. Long, Michael C. Kiritsy, Michelle Bellerose, Andrew J. Olive, Kenan C. Murphy, Kadamba Papavinasasundaram, Frederick Boehm, Charlotte Reames, and Christopher M. Sassetti

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Natural Polymorphism of Mycobacterium tuberculosis and CD8 T Cell Immunity, Rujapak Sutiwisesak

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A natural polymorphism of Mycobacterium tuberculosis in the esxH gene disrupts immunodomination by the TB10.4-specific CD8 T cell response, Rujapak Sutiwisesak, Nathan D. Hicks, Shayla Boyce, Kenan C. Murphy, Kadamba Papavinasasundaram, Stephen M. Carpenter, Julie Boucau, Neelambari Joshi, Sylvie Le Gall, Sarah M. Fortune, Christopher M. Sassetti, and Samuel M. Behar

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In vitro and in vivo characterization of a recombinant rhesus cytomegalovirus containing a complete genome, Husam Taher, Xiaofei E, Timothy F. Kowalik, and Daniel Malouli

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Molecular Assessment of Epiretinal Membrane: Activated Microglia, Oxidative Stress and Inflammation, Sushma Vishwakarma, Rishikesh Kumar Gupta, Saumya Jakati, Mudit Tyagi, Rajeev Reddy Pappuru, Keith Reddig, Gregory M. Hendricks, Michael R. Volkert, Hemant Khanna, Jay Chhablani, and Inderjeet Kaur

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Preventing Neurodegeneration by Controlling Oxidative Stress: The Role of OXR1, Michael R. Volkert and David J. Crowley

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NHR-49/PAARα and HLH-30/TFEB cooperate for C. elegans host defense via a flavin-containing monooxygenase, Khursheed A. Wani

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Evaluation of IL-1 Blockade as an Adjunct to Linezolid Therapy for Tuberculosis in Mice and Macaques, Caylin G. Winchell, Bibhuti B. Mishra, Jia Yao Phuah, Samantha J. Nelson, Christopher M. Sassetti, and JoAnne L. Flynn

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Poly(A)-Binding Protein Regulates the Efficiency of Translation Termination, Chan Wu, Bijoyita Roy, Feng He, Kevin Yan, and Allan Jacobson

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Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant, Leonid Yurkovetskiy, Thomas Nyalile, Yetao Wang, William E. Diehl, Ann Dauphin, Claudia Carbone, Kristen Veinotte, Shawn B Egri, James B. Munro, Pardis C. Sabeti, Christos A. Kyratsous, Natalya V. Dudkina, Kuang Shen, and Jeremy Luban

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SARS-CoV-2 Spike protein variant D614G increases infectivity and retains sensitivity to antibodies that target the receptor binding domain [preprint], Leonid Yurkovetskiy, Thomas Nyalile, Yetao Wang, William E. Diehl, Ann Dauphin, Claudia Carbone, Kristen Veinotte, Shawn B. Egri, Pardis C. Sabeti, Christos Kyratsous, James B. Munro, Kuang Shen, and Jeremy Luban

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Toll-like receptor-mediated innate immunity against herpesviridae infection: a current perspective on viral infection signaling pathways, Wenjin Zheng, Qing Xu, Yiyuan Zhang, Xiaofei E, Wei Gao, Mogen Zhang, Weijie Zhai, Ronaldjit Singh Rajkumar, and Zhijun Liu

Publications from 2019

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Comparative Pangenomics of the Mammalian Gut Commensal Bifidobacterium longum, Korin Albert, Asha Rani, and David Sela

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Regulatory asymmetry in the negative single-input module network motif: Role of network size, growth rate and binding affinity [preprint], Zulfikar Ali, Vinuselvi Parisutham, Sandeep Choubey, and Robert C. Brewster

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A Disintegrin and Metalloproteinase 9 Domain (ADAM9) Is a Major Susceptibility Factor in the Early Stages of Encephalomyocarditis Virus Infection, Lindsey E. Bazzone, Michael King, Christopher R. MacKay, Pyae Phyo Kyawe, Paul Meraner, Daniel Lindstrom, Joselyn Rojas-Quintero, Caroline A. Owen, Jennifer P. Wang, Abraham L. Brass, Evelyn A. Kurt-Jones, and Robert W. Finberg

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Common Variants in the Glycerol Kinase Gene Reduce Tuberculosis Drug Efficacy, Michelle M. Bellerose, Seung-Hun Baek, Chuan-Chin Huang, Caitlin E. Moss, Eun-Ik Koh, Megan K. Proulx, Clare M. Smith, Richard E. Baker, Jong Seok Lee, Seokyong Eum, Sung Jae Shin, Sang-Nae Cho, Megan Murray, and Christopher M. Sassetti

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A Persistence Detector for Metabolic Network Rewiring in an Animal, Jote T. Bulcha, Gabrielle E. Giese, Zulfikar Ali, Yong-Uk Lee, Melissa D. Walker, Amy D. Holdorf, L. Safak Yilmaz, Robert C. Brewster, and Albertha J. M. Walhout

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RE: Preventability of hospital onset bacterermia and fungemia: A pilot study of potential healthcare-associated infection outcome measure, by Dantes et al (2019), Anna M. Civitarese, Eric Ruggieri, Debbie Mack, Stephen O. Heard, Michael Mitchell, Craig M. Lilly, Karen E. Landry, Richard T. Ellison III, and J Matthias Walz

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Comparison of Immune Responses to Different Versions of VLP Associated Stabilized RSV Pre-Fusion F Protein, Lori M. Cullen, Madelyn R. Schmidt, Gretel M. Torres, Adam A. Capoferri, and Trudy G. Morrison

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Upper Gastrointestinal Perforations: A Possible Danger of Antibiotic Overuse, Vijaya Daniel, Stephanie Francalancia, Nili S. Amir, M. Didem Ayturk, Stacy B. Sanders, Jonathan R. Wisler, Courtney E. Collins, Doyle V. Ward, Catarina I. Kiefe, Beth A. McCormick, and Heena P. Santry

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OR14I1 is a receptor for the human cytomegalovirus pentameric complex and defines viral epithelial cell tropism, Xiaofei E, Paul Meraner, Ping Lu, Jill M. Perreira, Aaron M. Aker, William M. McDougall, Ronghua Zhuge, Gary C. Chan, Rachel M. Gerstein, Patrizia Caposio, Andrew D. Yurochko, Abraham L. Brass, and Timothy F. Kowalik

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Anti-drug Antibody Responses Impair Prophylaxis Mediated by AAV-Delivered HIV-1 Broadly Neutralizing Antibodies, Matthew R. Gardner, Ina Fetzer, Lisa M. Kattenhorn, Meredith E. Davis-Gardner, Amber S. Zhou, Barnett Alfant, Jesse A. Weber, Hema R. Kondur, Jose M. Martinez-Navio, Sebastian P. Fuchs, Ronald C. Desrosiers, Guangping Gao, Jeffrey D. Lifson, and Michael Farzan

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Alzheimer's Disease Microbiome Is Associated with Dysregulation of the Anti-Inflammatory P-Glycoprotein Pathway, John P. Haran, Shakti K. Bhattarai, Sage Foley, Protiva Dutta, Doyle V. Ward, Vanni Bucci, and Beth A. McCormick

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Frequent Loss of IRF2 in Cancers Leads to Immune Evasion through Decreased MHC Class I Antigen Presentation and Increased PD-L1 Expression, Barry Kriegsman, Pranitha Vangala, Benjamin J. Chen, Paul Meraner, Abraham L. Brass, Manuel Garber, and Kenneth L. Rock

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Viral Infection or IFN-alpha Alters Mitotic Spindle Orientation by Modulating Pericentrin Levels, William M. McDougall, Jill Perreira, Hui-Fang Hung, Anastassiia Vertii, E. Xiaofei, Wendy Zimmerman, Timothy F. Kowalik, Stephen J. Doxsey, and Abraham L. Brass

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A Novel PHOX/CD38/MCOLN1/TFEB Axis Important For Macrophage Activation During Bacterial Phagocytosis [preprint], Mehran Najibi, Joseph A. Moreau, Havisha H. Honwad, and Javier E. Irazoqui

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Evaluation of portable colposcopy and human papillomavirus testing for screening of cervical cancer in rural China, Haley Newman, Jilin Hu, Xiao Li, Jing He, Leslie Bradford, Songmei Shan, Xiaomei Wu, Bin Zhu, Wenyang Yang, Bingqin Fu, Baosheng Zhu, and Guangping Gao

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Differential skewing of donor-unrestricted and gammadelta T cell repertoires in tuberculosis-infected human lungs, Paul Ogongo, Adrie Jc. Steyn, Farina Karim, Kaylesh J. Dullabh, Ismael Awala, Rajhmun Madansein, Alasdair Leslie, and Samuel M. Behar

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Cognitive and Microbiome Impacts of Experimental Ancylostoma ceylanicum Hookworm Infections in Hamsters, Samuel C. Pan, Doyle V. Ward, Yunqiang Yin, Yan Hu, Elfawal A. Mostafa, Robert E. Clark, and Raffi V. Aroian

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The structure of the endogenous ESX-3 secretion system, Nicole Poweleit, Nadine Czudnochowski, Rachel Nakagawa, Donovan Trinidad, Kenan C. Murphy, Christopher M. Sassetti, and Oren S. Rosenberg

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Smooth muscle cell-specific TMEM16A deletion does not alter Ca2+ signaling, uterine contraction, gestation length or litter size in micedagger, Mingzi Qu, Ping Lu, Karl D. Bellve, Kevin E. Fogarty, Lawrence M. Lifshitz, Fangxiong Shi, and Ronghua ZhuGe

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Phosphorylation on PstP controls cell wall metabolism and antibiotic tolerance in Mycobacterium smegmatis [preprint], Farah Shamma, Kadamba Papavinasasundaram, Aditya Bandekar, Christopher M. Sassetti, and Cara C. Boutte

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Functionally Overlapping Variants Control Tuberculosis Susceptibility in Collaborative Cross Mice, Clare M. Smith, Megan K. Proulx, Rocky Lai, Michael C. Kiritsy, Timothy A. Bell, Pablo Hock, Fernando Pardo-Manuel de Villena, Martin T. Ferris, Richard E. Baker, Samuel M. Behar, and Christopher M. Sassetti

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Statistical analysis of variability in TnSeq data across conditions using zero-inflated negative binomial regression, Siddharth Subramaniyam, Michael A. DeJesus, Anisha Zaveri, Clare M. Smith, Richard E. Baker, Sabine Ehrt, Dirk Schnappinger, Christopher M. Sassetti, and Thomas R. Ioerger

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Interferon-induced transmembrane protein 3 blocks fusion of sensitive but not resistant viruses by partitioning into virus-carrying endosomes, Krishna C. Suddala, Christine C. Lee, Paul Meraner, Mariana Marin, Ruben M. Markosyan, Tanay M. Desai, Fredric S. Cohen, Abraham L. Brass, and Gregory B. Melikyan

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A Safe and Reliable Technique for CNS Delivery of AAV Vectors in the Cisterna Magna, Toloo Taghian, Miklos G. Marosfoi, Ajit S. Puri, Oguz Cataltepe, Robert M. King, Deborah Fernau, Ana Rita Batista, Terence R. Flotte, Diane McKenna-Yasek, Phillip W. L. Tai L, Neil Aronin, Matthew J. Gounis, Miguel Sena-Esteves, and Heather L. Gray-Edwards

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Gene Silencing With siRNA (RNA Interference): A New Therapeutic Option During Ex Vivo Machine Liver Perfusion Preservation, Max F. Thijssen, Isabel M. A. Bruggenwirth, Andrew R. Gillooly, Anastasia Khvorova, Timothy F. Kowalik, and Paulo N.A. Martins

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Gene Delivery to Nonhuman Primate Preimplantation Embryos Using Recombinant Adeno-Associated Virus, Dan Wang, Yuyu Niu, Lingzhi Ren, Yu Kang, Phillip W. L. Tai, Chenyang Si, Craig A. Mendonca, Hong Ma, Guangping Gao, and Weizhi Ji

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A Nutrition-Longevity Tradeoff Enforced by Innate Immunity, Khursheed A. Wani, Debanjan Goswamy, and Javier E. Irazoqui

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Nervous system control of intestinal host defense in C. elegans, Khursheed A. Wani, Debanjan Goswamy, and Javier E. Irazoqui

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Integration of genomic and clinical data augments surveillance of healthcare-acquired infections, Doyle V. Ward, Deborah Mack, Douglas J. Buell, Bruce A. Barton, Peter Lazar, Jomol Mathew, and Richard T. Ellison III