The Department of Microbiology and Physiological Systems (MaPS) was founded in 2010, and is the product of a merger between two departments, one focused on microbiology, genetics, and immunology, and the other focused on physiology. Capitalizing on the strength of the respective scientific research programs, the resulting department has strong and synergistic expertise in bacterial and viral pathogenesis, immunology, signal transduction, and fundamental cellular physiology. Current departmental research targets include viral and bacterial pathogens affecting the nervous, respiratory, and digestive systems. The mission of the new department is to address important biological questions broadly relevant to infectious disease and encompassing multiple levels of biological organization, including an understanding of pathogen effects on their target organ systems. This collection showcases the journal articles and other publications and presentations written by faculty and researchers of the Department of Microbiology and Physiological Systems. See earlier collections for selected Physiology and Molecular Genetics and Microbiology publications published before the departmental merger.

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Publications from 2022

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Oropharyngeal Microbiome Profiled at Admission is Predictive of the Need for Respiratory Support Among COVID-19 Patients [preprint], Evan S. Bradley, Abigail L. Zeamer, Vanni Bucci, Lindsey Cincotta, Marie-Claire Salive, Protiva Dutta, Shafik Mutaawe, Otuwe Anya, Christopher Tocci, Ann M. Moormann, Doyle V. Ward, Beth A. McCormick, and John P. Haran

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Conformational dynamics and allosteric modulation of the SARS-CoV-2 spike, Marco A. Diaz-Salinas, Qi Li, Ejemel Monir, Leonid Yurkovetskiy, Jeremy Luban, Kuang Shen, Yang Wang, and James B. Munro

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Gut Microbiota Regulation of P-Glycoprotein in the Mammalian Intestinal Epithelium to Suppress Aberrant Inflammation and Maintain Homeostasis, Sage E. Foley

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Containing the spread of mumps on college campuses, Mirai Shah, Gabrielle Ferra, Susan Fitzgerald, Paul J. Barreira, Pardis C. Sabeti, and Andres Colubri

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Comparison of Rapid Antigen Tests’ Performance between Delta (B.1.61.7; AY.X) and Omicron (B.1.1.529; BA1) Variants of SARS-CoV-2: Secondary Analysis from a Serial Home Self-Testing Study [preprint], Apurv Soni, Carly Herbert, Andreas Filippaios, John P. Broach, Andres Colubri, Nisha Fahey, Kelsey Woods, Janvi Nanavati, Colton Wright, Taylor Orwig, Karen Gilliam, Honghuang Lin, Laurel O'Connor, Caitlin Pretz, M. Didem Ayturk, Elizabeth Aaker Orvek, Julie M. Flahive, Peter Lazar, Qiming Shi, Laura L. Gibson, Pamela Stamegna, Nathaniel S. Hafer, Katherine Luzuriaga, Bruce A. Barton, David D. McManus, and RADx Clinical Studies Core team and Test Us At Home Investigators

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The case for altruism in institutional diagnostic testing, Ivan Specht, Kian Sani, Yolanda Botti-Lodovico, Michael Hughes, Kristin Heumann, Amy Bronson, John Marshall, Emily Baron, Eric Parrie, Olivia Glennon, Ben Fry, Andres Colubri, and Pardis C. Sabeti

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Spatial transcriptomic reconstruction of the mouse olfactory glomerular map suggests principles of odor processing, I-Hao Wang, Gregory Andrews, Elisa Donnard, Violeta Duran-Laforet, Travis E. Faust, Manuel Garber, Christina E. Baer, Dorothy P. Schafer, Zhiping Weng, and Paul L. Greer

Publications from 2021

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Controlling gene expression timing through gene regulatory architecture [preprint], Md Zulfikar Ali and Robert C. Brewster

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Stability and conformation of the dimeric HIV-1 genomic RNA 5'UTR, Robert J. Blakemore, Cleo Burnett, Canessa Swanson, Siarhei Kharytonchyk, Alice Telesnitsky, and James B. Munro

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Evolution of protection after maternal immunization for respiratory syncytial virus in cotton rats [preprint], Jorge C.G. Blanco, Lori McGinnes Cullen, Arash Kamali, Fatoumata Y. D. Sylla, Marina S. Boukhavalova, and Trudy G. Morrison

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The Origins and Future of Sentinel: An Early-Warning System for Pandemic Preemption and Response, Yolanda Botti-Lodovico, Andres Colubri, Pardis C. Sabeti, and Christian Happi

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The Urinary Microbiome of Older Adults Residing in a Nursing Home Varies with Duration of Residence and Shows Increases in Potential Pathogens, Evan Bradley, Brent Schell, Doyle V. Ward, Vanni Bucci, Abigail Zeamer, and John P. Haran

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Viral vector platforms within the gene therapy landscape, Jote T. Bulcha, Yi Wang, Hong Ma, Phillip W. L. Tai, and Guangping Gao

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Host immunity increases Mycobacterium tuberculosis reliance on cytochrome bd oxidase, Yi Cai, Eleni Jaecklein, Jared S. Mackenzie, Kadamba Papavinasasundaram, Andrew J. Olive, Xinchun Chen, Adrie J.C. Steyn, and Christopher M. Sassetti

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Comparative analysis reveals the long-term co-evolutionary history of parvoviruses and vertebrates [preprint], Matthew A. Campbell, Shannon Loncar, Robert M. Kotin, and Robert J. Gifford

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Engineering adeno-associated viral vectors to evade innate immune and inflammatory responses, Ying Kai Chan, Manish Muhuri, Phillip W. L. Tai, Jun Xie, Guangping Gao, and George M. Church

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Low-Dose Recombinant Adeno-Associated Virus-Mediated Inhibition of Vascular Endothelial Growth Factor Can Treat Neovascular Pathologies Without Inducing Retinal Vasculitis, Shun-Yun Cheng, Yongwen Luo, Anneliese Malachi, Jihye Ko, Qin Su, Jun Xie, Bo Tian, Haijiang Lin, Xiao Ke, Qiang Zheng, Phillip W. L. Tai, Guangping Gao, and Claudio Punzo

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Modeling site-specific nucleotide biases affecting Himar1 transposon insertion frequencies in TnSeq datasets [preprint], Sanjeevani Choudhery, A. Jacob Brown, Chidiebere Akusobi, Eric J. Rubin, Christopher M. Sassetti, and Thomas R. Ioerger

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The DNA Translocase of Mycobacteria Is an Essential Protein Required for Growth and Division, Alexander Czuchra

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Gut microbiota regulation of P-glycoprotein in the intestinal epithelium in maintenance of homeostasis, Sage E. Foley, Christine Tuohy, Merran Dunford, Michael J. Grey, Heidi De Luca, Caitlin Cawley, Rose L. Szabady, Ana Maldonado-Contreras, JeanMarie Houghton, Doyle V. Ward, Randall J. Mrsny, and Beth A. McCormick

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A highly homogeneous polymer composed of tetrahedron-like monomers for high-isotropy expansion microscopy, Ruixuan Gao, Chih-Chieh Jay Yu, Linyi Gao, Kiryl D. Piatkevich, Rachael L. Neve, James B. Munro, Srigokul Upadhyayula, and Edward S. Boyden

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Multimodal profiling of lung granulomas reveals cellular correlates of tuberculosis control [preprint], Hannah P. Gideon, Samuel M. Behar, JoAnne L. Flynn, Sarah M. Fortune, and Alex K. Shalek

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The epithelial-specific ER stress sensor IRE1β enables host-microbiota crosstalk to affect colon goblet cell development [preprint], Michael J. Grey, Heidi De Luca, Doyle V. Ward, Irini A. M. Kreulen, Sage E. Foley, Jay R. Thiagarajah, Beth A. McCormick, Jerrold R. Turner, and Wayne I. Lencer

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Two-Way Regulation of MmpL3 Expression Identifies and Validates Inhibitors of MmpL3 Function in Mycobacterium tuberculosis, Shipra Grover, Curtis A. Engelhart, Esther Perez-Herran, Wei Li, Katherine A. Abrahams, Kadamba Papavinasasundaram, James M. Bean, Christopher M. Sassetti, Alfonso Mendoza-Losana, Gurdyal S. Besra, Mary Jackson, and Dirk Schnappinger

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Quantifying the regulatory role of individual transcription factors in Escherichia coli [preprint], Sunil Guharajan, Shivani Chhabra, Vinuselvi Parisutham, and Robert C. Brewster

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Inflammation-type dysbiosis of the oral microbiome associates with the duration of COVID-19 symptoms and long-COVID, John P. Haran, Evan Bradley, Abigail Zeamer, Lindsey Cincotta, Marie-Claire Salive, Protiva Dutta, Shafik Mutaawe, Otuwe Anya, Mario Meza-Segura, Ann M. Moormann, Doyle V. Ward, Beth A. McCormick, and Vanni Bucci

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Aging, Frailty, and the Microbiome - How Dysbiosis Influences Human Aging and Disease, John P. Haran and Beth A. McCormick

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Virtualized clinical studies to assess the natural history and impact of gut microbiome modulation in non-hospitalized patients with mild to moderate COVID-19 a randomized, open-label, prospective study with a parallel group study evaluating the physiologic effects of KB109 on gut microbiota structure and function: a structured summary of a study protocol for a randomized controlled study, John P. Haran, Jose C. Pinero, Yan Zheng, Norma Alonzo Palma, and Mark Wingertzahn

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Virtualized Clinical Studies to Assess the Natural History and Impact of Gut Microbiome Modulation in Non-Hospitalized Patients with Mild to Moderate COVID-19 a Randomized, Open-Label, Prospective Study with a Parallel Group Study Evaluating the Physiologic Effects of KB109 on Gut Microbiota Structure and Function: A Structured Summary of a Study Protocol for a Randomized Controlled Study [preprint], John P. Haran, Jose C. Pinero, Yan Zheng, Norma Alonzo Palma, and Mark Wingertzahn

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The high prevalence of Clostridioides difficile among nursing home elders associates with a dysbiotic microbiome, John P. Haran, Doyle V. Ward, Shakti K. Bhattarai, Ethan Loew, Protiva Dutta, Amanda Higgins, Beth A. McCormick, and Vanni Bucci

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The Nursing Home Older Adult Gut Microbiome Composition Shows Time-dependent Dysbiosis and is Influenced by Medication Exposures, Age, Environment, and Frailty, John P. Haran, Abigail Zeamer, Doyle V. Ward, Protiva Dutta, Vanni Bucci, and Beth A. McCormick

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Targeting the Microbiome With KB109 in Outpatients with Mild to Moderate COVID-19 Reduced Medically Attended Acute Care Visits and Improved Symptom Duration in Patients With Comorbidities [preprint], John P. Haran, Yan Zheng, Katharine Knobil, Norma Alonzo Palma, Jonathan F. Lawrence, and Mark A. Wingertzahn

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Dcp2 C-terminal Cis-Binding Elements Control Selective Targeting of the Decapping Enzyme by Forming Distinct Decapping Complexes [preprint], Feng He, Chan Wu, and Allan S. Jacobson

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The Mycobacterium tuberculosis transposon sequencing database (MtbTnDB): a large-scale guide to genetic conditional essentiality [preprint], Adrian Jinich, Anisha Zaveri, Michael A. DeJesus, Emanuel Flores-Bautista, Clare M. Smith, Christopher M. Sassetti, Jeremy M. Rock, Sabine Ehrt, Dirk Schnappinger, Thomas R. Ioerger, and Kyu Rhee

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Chemical-genetic interaction mapping links carbon metabolism and cell wall structure to tuberculosis drug efficacy [preprint], Eun-Ik Koh, Megan K. Proulx, Kenan C. Murphy, Kadamba Papavinasasundaram, Charlotte Reames, Richard E. Baker, Roshanak Aslebagh, Scott A. Shaffer, and Christopher M. Sassetti

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Sciviewer enables interactive visual interrogation of single-cell RNA-Seq data from the python programming environment, Dylan Kotliar and Andres Colubri

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Coagulation factor IX gene transfer to non-human primates using engineered AAV3 capsid and hepatic optimized expression cassette, Sandeep R .P. Kumar, Jun Xie, Shilang Hu, Jihye Ko, Qifeng Huang, Harrison C. Brown, Alok Srivastava, David M. Markusic, Christopher B. Doering, H. Trent Spencer, Arun Srivastava, Guangping Gao, and Roland W. Herzog

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Canavan Disease as a Model for Gene Therapy-Mediated Myelin Repair, Anoushka Lotun, Dominic J. Gessler, and Guangping Gao

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Granulocytes act as a niche for Mycobacterium tuberculosis growth, Rustin R. Lovewell, Christina E. Baer, Bibhuti B. Mishra, Clare M. Smith, and Christopher M. Sassetti

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The DHODH inhibitor PTC299 arrests SARS-CoV-2 replication and suppresses induction of inflammatory cytokines, Jeremy Luban, Caterina Strambio-De-Castillia, Yetao Wang, Allan Jacobson, and Stuart W. Peltz

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The Role of CD4 T Cell Help in Effective CD8 T Cell Responses during Mycobacterium Tuberculosis Infection, Yu-Jung Lu

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CD4 T cell help prevents CD8 T cell exhaustion and promotes control of Mycobacterium tuberculosis infection, Yu-Jung Lu, Palmira Barreira-Silva, Shayla Boyce, Jennifer Powers, Kelly Cavallo, and Samuel M. Behar

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CD4 T cell help prevents CD8 T cell exhaustion and promotes control of Mycobacterium tuberculosis infection [preprint], Yu-Jung Lu, Palmira Barreira-Silva, Shayla Boyce, Jennifer Powers, Kelly Cavallo, and Samuel M. Behar

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Transcriptome-wide investigation of stop codon readthrough in Saccharomyces cerevisiae, Kotchaphorn Mangkalaphiban, Feng He, Robin Ganesan, Chan Wu, Richard E. Baker, and Allan Jacobson

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IFNγ Mediated Monocyte Metabolic Reprogramming, Katelyn J. McCann

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Cell wall damage reveals spatial flexibility in peptidoglycan synthesis and a non-redundant role for RodA in mycobacteria [preprint], Emily S. Melzer, Takehiro Kado, Alam García-Heredia, Kuldeepkumar Ramnaresh Gupta, Xavier Meniche, Yasu S. Morita, Christopher M. Sassetti, E. Hesper Rego, and M. Sloan Siegrist

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Characterization of Drug-Resistant Lipid-Dependent Differentially Detectable Mycobacterium tuberculosis, Annelies W. Mesman, Seung-Hun Baek, Chuan-Chin Huang, Young-Mi Kim, Sang-Nae Cho, Thomas R. Ioerger, Nadia N. Barreda, Roger Calderon, Christopher M. Sassetti, and Megan B. Murray

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SepA Enhances Shigella Invasion of Epithelial Cells by Degrading Alpha-1 Antitrypsin and Producing a Neutrophil Chemoattractant, Mario Meza-Segura, James R. Birtley, Ana Maldonado-Contreras, Christian Mueller, Karl J. Simin, Lawrence J. Stern, and Beth A. McCormick

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Overcoming innate immune barriers that impede AAV gene therapy vectors, Manish Muhuri, Yukiko Maeda Garrison, Hong Ma, Sanjay Ram, Katherine A. Fitzgerald, Phillip W. L. Tai, and Guangping Gao

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Novel Combinatorial MicroRNA-Binding Sites in AAV Vectors Synergistically Diminish Antigen Presentation and Transgene Immunity for Efficient and Stable Transduction, Manish Muhuri, Wei Zhan, Yukiko Maeda Garrison, Jia Li, Anoushka Lotun, Jennifer Chen, Katelyn E. Sylvia, Ishani Dasgupta, Motahareh Arjomandnejad, Thomas Nixon, Allison M. Keeler, Sangeetha Manokaran, Ran He, Qin Su, Phillip W. L. Tai, and Guangping Gao

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Antibody affinity as a driver of signal generation in a paper-based immunoassay for Ebola virus surveillance, Lara P. Murray, Ramesh Govindan, Andrea C. Mora, James B. Munro, and Charles R. Mace

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Proanthocyanidin-enriched cranberry extract induces resilient bacterial community dynamics in a gnotobiotic mouse model, Catherine C. Neto, Benedikt M. Mortzfeld, John R. Turbitt, Shakti K. Bhattarai, Vladimir Yeliseyev, Nicholas DiBenedetto, Lynn Bry, and Vanni Bucci

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Tissue-resident-like CD4+ T cells secreting IL-17 control Mycobacterium tuberculosis in the human lung, Paul Ogongo, Liku B. Tezera, Amanda Ardain, Shepherd Nhamoyebonde, Duran Ramsuran, Alveera Singh, Abigail Ng'oepe, Farina Karim, Taryn Naidoo, Khadija Khan, Kaylesh J. Dullabh, Michael Fehlings, Boon Heng. Lee, Alessandra Nardin, Cecilia S. Lindestam Arlehamn, Alessandro Sette, Samuel M. Behar, Adrie Jc. Steyn, Rajhmun Madansein, Henrik N. Kloverpris, Paul T. Elkington, and Alasdair Leslie

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Cranberry Proanthocyanidins and Dietary Oligosaccharides Synergistically Modulate Lactobacillus plantarum Physiology, Ezgi Ozcan, Michelle R. Rozycki, and David A. Sela

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Effect of Levodopa Initiation on the Gut Microbiota in Parkinson's Disease, Natalia Palacios, Anas Hannoun, Julie M. Flahive, Doyle V. Ward, Kelsey Goostrey, Anindita Deb, and Kara M. Smith

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Oxidative Stress Resistance 1 Gene Therapy Retards Neurodegeneration in the rd1 Mutant Mouse Model of Retinopathy, Bhubanananda Sahu, Laura Moreno-Leon, Wei Zhang, Nikita Puranik, Ramesh Periasamy, Hemant Khanna, and Michael R. Volkert

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CNBP, REL, and BHLHE40 variants are associated with IL-12 and IL-10 responses and tuberculosis risk [preprint], Javeed A. Shah, Christopher M. Sassetti, and Katherine A. Fitzgerald

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c-Jun N-terminal kinase (JNK) signaling contributes to cystic burden in polycystic kidney disease [preprint], Abigail O. Smith, Julie A. Jonassen, Kenley Preval, Roger J. Davis, and Gregory J. Pazour

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Sirtuin 3 Downregulation in Mycobacterium tuberculosis-Infected Macrophages Reprograms Mitochondrial Metabolism and Promotes Cell Death, Lorissa J. Smulan, Nuria M. Martinez, Michael C. Kiritsy, Chido L. Kativhu, Kelly Cavallo, Christopher M. Sassetti, Amit Singhal, Heinz G. Remold, and Hardy Kornfeld

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The Case for Altruism in Institutional Diagnostic Testing [preprint], Ivan Specht, Kian Sani, Yolanda Botti-Lodovico, Michael Hughes, Kristin Heumann, Amy Bronson, John Marshall, Emily Baron, Eric Parrie, Olivia Glennon, Ben Fry, Andres Colubri, and Pardis C. Sabeti

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A budding yeast model for human disease mutations in the EXOSC2 cap subunit of the RNA exosome complex, Maria C. Sterrett, Liz Enyenihi, Sara W. Leung, Laurie Hess, Sarah E. Strassler, Daniela Farchi, Richard S. Lee, Elise S. Withers, Isaac Kremsky, Richard E. Baker, Munira A. Basrai, Ambro van Hoof, Milo B. Fasken, and Anita H. Corbett

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Efficacious, safe, and stable inhibition of corneal neovascularization by AAV-vectored anti-VEGF therapeutics, Wenqi Su, Shuo Sun, Bo Tian, Phillip W. L. Tai, Yongwen Luo, Jihye Ko, Wei Zhan, Xiao Ke, Qiang Zheng, Xiaorong Li, Hua Yan, Guangping Gao, and Haijiang Lin

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Start codon disruption with CRISPR/Cas9 prevents murine Fuchs' endothelial corneal dystrophy, Hironori Uehara, Guangping Gao, and Balamurali K. Ambati

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Common Polymorphisms in the Glycoproteins of Human Cytomegalovirus and Associated Strain-Specific Immunity, Hsuan-Yuan Wang, Sarah M. Valencia, Susanne P. Pfeifer, Jeffrey D. Jensen, Timothy F. Kowalik, and Sallie R. Permar

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NHR-49/PPAR-alpha and HLH-30/TFEB cooperate for C. elegans host defense via a flavin-containing monooxygenase, Khursheed A. Wani, Debanjan Goswamy, Stefan Taubert, Ramesh Ratnappan, Arjumand Ghazi, and Javier E. Irazoqui

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The Intestinal and Oral Microbiomes Are Robust Predictors of COVID-19 Severity the Main Predictor of COVID-19-related Fatality [preprint], Doyle V. Ward, Shakti Bhattarai, Mayra Rojas-Correa, Ayan Purkayastha, Devon Holler, Ming Da Qu, William G. Mitchell, Jason D. Yang, Samuel Fountain, Abigail Zeamer, Catherine Forconi, Gavin Fujimori, Boaz Odwar, Caitlin Cawley, Beth A. McCormick, Ann M. Moormann, Mireya Wessolossky, Vanni Bucci, and Ana Maldonado-Contreras

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Gastrointestinal microbiota composition predicts peripheral inflammatory state during treatment of human tuberculosis, Matthew F. Wipperman, Shakti K. Bhattarai, Charles Kyriakos Vorkas, Venkata Suhas Maringati, Ying Taur, Laurent Mathurin, Katherine McAulay, Stalz Charles Vilbrun, Daphie Francois, James Bean, Kathleen F. Walsh, Carl Nathan, Daniel W. Fitzgerald, Michael S. Glickman, and Vanni Bucci

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Cellular and Tissue Selectivity of AAV Serotypes for Gene Delivery to Chondrocytes and Cartilage, Dong Suk Yoon, Kyoung-Mi Lee, Sehee Cho, Eun Ae Ko, Jihyun Kim, Sujin Jung, Jae-Hyuck Shim, Guangping Gao, Kwang Hwan Park, and Jin Woo Lee

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Vectored Immunotherapeutics for Infectious Diseases: Can rAAVs Be The Game Changers for Fighting Transmissible Pathogens?, Wei Zhan, Manish Muhuri, Phillip W. L. Tai, and Guangping Gao

Publications from 2020

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Probing Mechanisms of Transcription Elongation Through Cell-to-Cell Variability of RNA Polymerase, Zulfikar Ali, Sandeep Choubey, Dipjyoti Das, and Robert C. Brewster (Biophysical journal, 2020-04-07)

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Inherent regulatory asymmetry emanating from network architecture in a prevalent autoregulatory motif, Zulfikar Ali, Vinuselvi Parisutham, Sandeep Choubey, and Robert C. Brewster

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Skp, Cullin, F-box (SCF)-Met30 and SCF-Cdc4-Mediated Proteolysis of CENP-A Prevents Mislocalization of CENP-A for Chromosomal Stability in Budding Yeast, Wei-Chun Au, Richard E. Baker, and Munira A. Basrai

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Cell Cycle Associated Gene Expression Predicts Function in Mycobacteria, Aditya C. Bandekar

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Cell cycle-associated expression patterns predict gene function in mycobacteria [preprint], Aditya Bandekar, Sishir Subedi, Thomas Ioerger, and Christopher M. Sassetti

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Genetic Identification of Novel Mycobacterium tuberculosis Susceptibility and Survival Mechanisms During Antibiotic Treatment, Michelle M. Bellerose

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Distinct Bacterial Pathways Influence the Efficacy of Antibiotics against Mycobacterium tuberculosis, Michelle Bellerose, Megan K. Proulx, Clare M. Smith, Richard E. Baker, Thomas R. Ioerger, and Christopher M. Sassetti

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Docosanoic acid conjugation to siRNA enables functional and safe delivery to skeletal and cardiac muscles, Annabelle Biscans, Jillian Caiazzi, Nicholas McHugh, Vignesh Hariharan, Manish Muhuri, and Anastasia Khvorova

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Acidic pH Triggers Lipid Mixing Mediated by Lassa Virus GP, Uriel Bulow, Ramesh Govindan, and James B. Munro

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Host immunity increases Mycobacterium tuberculosis reliance on cytochrome bd oxidase [preprint], Yi Cai, Eleni Jaecklein, Jared Mackenzie, Kadamba Papavinasasundaram, Michigan State University, Xinchun Chen, Africa Health Research Institute, and Christopher M. Sassetti

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ORAN: A meta-modeling platform to drive real-life and online outbreak simulations, Andres Colubri

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Preventing Outbreaks through Interactive, Experiential Real-Life Simulations, Andres Colubri, Molly Kemball, Kian Sani, Chloe Boehm, Karen Mutch-Jones, Ben Fry, Todd Brown, and Pardis C. Sabeti

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Flexibility and constraint in preimplantation gene regulation in mouse [preprint], Colin C. Conine, Marina Krykbaeva, Lina Song, Robert C. Brewster, Nir Friedman, and Oliver J. Rando

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Comparisons of Antibody Populations in Different Pre-Fusion F VLP-Immunized Cotton Rat Dams and Their Offspring, Lori McGinnes Cullen, Marina S. Boukhvalova, Jorge C. G. Blanco, and Trudy G. Morrison

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Conformational changes in the Ebola virus membrane fusion machine induced by pH, Ca2+, and receptor binding, Dibyendu Kumar Das, Uriel Bulow, William E. Diehl, Natasha D. Durham, Fernando Senjobe, Kartik Chandran, Jeremy Luban, and James B. Munro

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Bifidobacterium infantis Metabolizes 2'Fucosyllactose-Derived and Free Fucose Through a Common Catabolic Pathway Resulting in 1,2-Propanediol Secretion, Liv R. Dedon, Ezgi Ozcan, Asha Rani, and David A. Sela

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Real-Time Analysis of Individual Ebola Virus Glycoproteins Reveals Pre-Fusion, Entry-Relevant Conformational Dynamics, Natasha D. Durham, Angela R. Howard, Ramesh Govindan, Fernando Senjobe, J. Maximilian Fels, William E. Diehl, Jeremy Luban, Kartik Chandran, and James B. Munro

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Dbf4-Dependent Kinase (DDK)-Mediated Proteolysis of CENP-A Prevents Mislocalization of CENP-A in Saccharomyces cerevisiae, Jessica R. Eisenstatt, Lars Boeckmann, Wei-Chun Au, Valerie Garcia, Levi Bursch, Josefina Ocampo, Michael Costanzo, Michael Weinreich, Robert A. Sclafani, Anastasia Baryshnikova, Chad L. Myers, Charles Boone, David J. Clark, Richard E. Baker, and Munira A. Basrai

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Single-cell profiling of tuberculosis lung granulomas reveals functional lymphocyte signatures of bacterial control [preprint], Hannah P. Gideon, Samuel M. Behar, and Alex Shalek

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Single-cell profiling of tuberculosis lung granulomas reveals functional lymphocyte signatures of bacterial control [preprint], Hannah P. Gideon, Samuel M. Behar, and Alex Shalek

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Analysis of Recombinant Adeno-Associated Virus (rAAV) Sample Morphology Using Negative Staining and High-Resolution Electron Microscopy, Gregory M. Hendricks, Miguel Sena-Esteves, and Guangping Gao

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Precision Cas9 Genome Editing in vivo with All-in-one, Self-targeting AAV Vectors [preprint], Raed Ibraheim, Phillip W. L. Tai, Aamir Mir, Nida Javeed, Jiaming Wang, Tomas Rodriguez, Samantha J. Nelson, Eraj Khokhar, Esther Mintzer, Stacy Maitland​, Yueying Cao, Guangping Gao, and Erik J. Sontheimer

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Key Roles of MiT Transcription Factors in Innate Immunity and Inflammation, Javier E. Irazoqui

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Imposed mutational meltdown as an antiviral strategy, Jeffrey D. Jensen, Ryan A. Stikeleather, Timothy F. Kowalik, and Michael Lynch

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Gp41-targeted antibodies restore infectivity of a fusion-deficient HIV-1 envelope glycoprotein, Vinita R. Joshi, Ruchi M. Newman, Melissa L. Pack, Karen A. Power, James B. Munro, Ken Okawa, Navid Madani, Joseph G. Sodroski, Aaron G. Schmidt, and Todd M. Allen

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M. tuberculosis Reprograms Hematopoietic Stem Cells to Limit Myelopoiesis and Impair Trained Immunity, Nargis Khan, Christopher M. Sassetti, and Maziar Divangahi

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Functional Genomics of Mammalian Innate Immunity, Michael C. Kiritsy

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A genome-wide screen in macrophages identifies new regulators of IFNγ-inducible MHCII that contribute to T cell activation [preprint], Michael C. Kiritsy, Michigan State University, Michigan State University, Michigan State University, Audrey E. Lord, M. Pontus A. Orning, Roland Elling, Katherine A. Fitzgerald, and Michigan State University

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Mitochondrial respiration contributes to the interferon gamma response in antigen presenting cells [preprint], Michael C. Kiritsy, Daniel Mott, Samuel M. Behar, Christopher M. Sassetti, and Andrew J. Olive

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CD11cHi monocyte-derived macrophages are a major cellular compartment infected by Mycobacterium tuberculosis, Jinhee Lee, Shayla Boyce, Jennifer Powers, Christina E. Baer, Christopher M. Sassetti, and Samuel M. Behar

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A C. elegans neuron both promotes and suppresses motor behavior to fine tune motor output [preprint], Zhaoyu Li, Jiejun Zhou, Khursheed A. Wani, Teng Yu, Elizabeth A. Ronan, University of Michigan - Ann Arbor, Jianfeng Liu, and X.Z. Shawn Xu