A systematic review and meta-analysis on herpes zoster and the risk of cardiac and cerebrovascular events
Authors
Erskine, NathanielTran, Hoang
Levin, Len L.
Ulbricht, Christine M.
Fingeroth, Joyce D.
Kiefe, Catarina I.
Goldberg, Robert J.
Singh, Sonal
UMass Chan Affiliations
Department of Family Medicine and Community HealthDivision of General Internal Medicine, Department of Medicine
Division of Infectious Diseases and Immunology, Department of Medicine
Lamar Soutter Library
Department of Quantitative Health Sciences
Document Type
Journal ArticlePublication Date
2017-07-27Keywords
Herpes Zoster/complicationsCerebrovascular Disorders
Herpes Zoster
Cerebrovascular Disorders
Systematic Review
Cardiology
Cardiovascular Diseases
Infectious Disease
Library and Information Science
Virus Diseases
UMCCTS funding
Metadata
Show full item recordAbstract
BACKGROUND: Patients who develop herpes zoster or herpes zoster ophthalmicus may be at risk for cerebrovascular and cardiac complications. We systematically reviewed the published literature to determine the association between herpes zoster and its subtypes with the occurrence of cerebrovascular and cardiac events. METHODS/RESULTS: Systematic searches of PubMed (MEDLINE), SCOPUS (Embase) and Google Scholar were performed in December 2016. Eligible studies were cohort, case-control, and self-controlled case-series examining the association between herpes zoster or subtypes of herpes zoster with the occurrence of cerebrovascular and cardiac events including stroke, transient ischemic attack, coronary heart disease, and myocardial infarction. Data on the occurrence of the examined events were abstracted. Odds ratios and their accompanying confidence intervals were estimated using random and fixed effects models with statistical heterogeneity estimated with the I2 statistic. Twelve studies examining 7.9 million patients up to 28 years after the onset of herpes zoster met our pre-defined eligibility criteria. Random and fixed effects meta-analyses showed that herpes zoster, type unspecified, and herpes zoster ophthalmicus were associated with a significantly increased risk of cerebrovascular events, without any evidence of statistical heterogeneity. Our meta-analysis also found a significantly increased risk of cardiac events associated with herpes zoster, type unspecified. CONCLUSIONS: Our results are consistent with the accumulating body of evidence that herpes zoster and herpes zoster ophthalmicus are significantly associated with cerebrovascular and cardiovascular events.Source
Erskine N, Tran H, Levin L, Ulbricht C, Fingeroth J, Kiefe C, Goldberg RJ, Singh S. A systematic review and meta-analysis on herpes zoster and the risk of cardiac and cerebrovascular events. PLoS One. 2017 Jul 27;12(7):e0181565. doi: 10.1371/journal.pone.0181565. eCollection 2017. Link to article on publisher's websiteDOI
10.1371/journal.pone.0181565Permanent Link to this Item
http://hdl.handle.net/20.500.14038/36187PubMed ID
28749981Related Resources
Link to article in PubMedRights
Copyright: © 2017 Erskine et al.Distribution License
http://creativecommons.org/licenses/by/4.0/ae974a485f413a2113503eed53cd6c53
10.1371/journal.pone.0181565