Insulin pump therapy in toddlers and preschool children with type 1 diabetes mellitus
Department of Pediatrics
Child Welfare; Child, Preschool; Diabetes Mellitus, Type 1; Diabetic Ketoacidosis; Dose-Response Relationship, Drug; Emergency Medical Services; Female; Hemoglobin A, Glycosylated; Humans; Hypoglycemic Agents; Infant; Infant Welfare; Insulin; *Insulin Infusion Systems; Male; North Carolina; Physicians; Severity of Illness Index; Treatment Outcome; Weight Gain
Cell Biology | Developmental Biology | Endocrinology
OBJECTIVE: To test whether glycemic control in young children could be achieved more effectively and safely by using continuous insulin infusions administered by insulin pumps.
STUDY DESIGN: We analyzed the effects of pump therapy in nine toddlers in whom type 1 diabetes developed between the ages of 10 and 40 months. After a mean of 13.7 months of therapy with multiple daily injections, patients were treated with insulin pumps for periods ranging from 7 to 19 months (mean, 12.7 months).
RESULTS: Before initiation of pump therapy, HbA1c levels averaged 9.5% +/- 0.4%, and patients had a mean of 0.52 episodes per month of severe hypoglycemia (uncontrolled shaking, inconsolable crying, disorientation, or seizures). After initiation of pump therapy, HbA1c levels declined to 7.9% +/- 0.3% (P 80%, reflecting increasing parental confidence and independence in diabetic care. Subjective assessments revealed significant improvements in quality of life and high levels of satisfaction with pump therapy.
CONCLUSIONS: Insulin pump therapy may provide an effective alternative for selected preschool children with type 1 diabetes.
DOI of Published Version
J Pediatr. 2002 Oct;141(4):490-5. Link to article on publisher's site
The Journal of pediatrics
Litton, Jean; Rice, Alan; Friedman, Nancy; Oden, Jon; Lee, Mary M.; and Freemark, Michael, "Insulin pump therapy in toddlers and preschool children with type 1 diabetes mellitus" (2002). Lee Lab Publications. 45.