The disappearing Barr body in breast and ovarian cancers
Department of Cell Biology
Breast Neoplasms; Chromosomes, Human, X; Female; Genes, BRCA1; Heterochromatin; Humans; Ovarian Neoplasms; Sex Chromatin
Interest has recently reawakened in whether loss of the heterochromatic X chromosome (Barr body) is prevalent in certain breast and ovarian cancers, and new insights into the mechanisms involved have emerged. Mitotic segregation errors commonly explain the loss of the inactive X chromosome (Xi), but compromise of Xi heterochromatin in some cancers may signal broader deficits of nuclear heterochromatin. The debated link between BRCA1 and Xi might reflect a general relationship between BRCA1 and heterochromatin, which could connect BRCA1 to both epigenetic and genetic instability. We suggest that heterochromatic instability is a common but largely unexplored mechanism, leading to widespread genomic misregulation and the evolution of some cancers.
DOI of Published Version
Nat Rev Cancer. 2007 Aug;7(8):628-33. Epub 2007 Jul 5. Link to article on publisher's site
Nature reviews. Cancer
Pageau GJ, Hall LL, Ganesan S, Livingston DM, Lawrence JB. (2007). The disappearing Barr body in breast and ovarian cancers. Lawrence Lab Publications. https://doi.org/10.1038/nrc2172. Retrieved from https://escholarship.umassmed.edu/lawrence/4