Duodenal intraepithelial lymphocytes in inflammatory disorders of the esophagus and stomach
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UMass Chan Affiliations
Department of PathologyDepartment of Cell Biology
Information Services, Academic Computing Services
Document Type
Journal ArticlePublication Date
2006-04-25Keywords
AdolescentAdult
Aged
Aged, 80 and over
Antigens, CD3
Biopsy, Needle
Case-Control Studies
Child
Child, Preschool
Duodenal Diseases
Endoscopy, Gastrointestinal
Esophagitis
Female
Gastritis
Humans
Immunohistochemistry
Infant
Intestinal Mucosa
Lymphocyte Count
Male
Middle Aged
Probability
Sampling Studies
Sensitivity and Specificity
T-Lymphocyte Subsets
Gastroenterology
Hepatology
Metadata
Show full item recordAbstract
BACKGROUND and AIMS: Duodenal cluster designation 3 positive (CD3+) intraepithelial T lymphocytes (IELs) are increased in gluten-sensitive enteropathy (GSE) and, because of the dispersed nature of the gut immune system, might also be increased in mucosa distant from the duodenum. Conversely, little is known about their frequency in the duodenum during inflammatory conditions of the stomach and esophagus. This study assessed whether CD3+ IELs are increased in duodenal biopsies in patients with esophagitis or gastritis relative to normal control subjects. METHODS: Cases (n=46) with concurrent mucosal biopsies of the duodenum, stomach, and esophagus were divided into 4 groups: I, no inflammation in any site; II, active esophagitis only; III, chronic active gastritis only, with Helicobacter pylori bacteria; IV, chronic gastritis only, without H pylori bacteria. Immunostains against CD3 were performed by using standard techniques, the number of CD3+ cells/100 enterocytes in 3 well-oriented villi was recorded, and the results for the groups were compared statistically. RESULTS: The average number of CD3+ IELs/100 enterocytes for each group was I, 6.7; II, 11.8; III, 7.2; and IV, 9.1. The differences among the groups were not statistically significant. There was no correlation between the number of duodenal IELs and severity of inflammation, patient age or sex, or symptoms. CONCLUSIONS: Duodenal mucosal biopsies from patients with esophagitis and/or gastritis may have a slightly increased number of CD3+ IELs relative to normal control subjects. This finding may reflect an underlying mechanism of diffuse inflammation in the gastrointestinal tract.Source
Clin Gastroenterol Hepatol. 2006 May;4(5):631-4. Link to article on publisher's siteDOI
10.1016/j.cgh.2005.12.028Permanent Link to this Item
http://hdl.handle.net/20.500.14038/35322PubMed ID
16630772Related Resources
Link to article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.cgh.2005.12.028