Plasma D-dimer and peritoneal CA-125 levels as predictors of disease status in ovarian carcinoma

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Information Services, Academic Computing Services; Department of Cell Biology; Graduate School of Nursing

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Antigens, Tumor-Associated, Carbohydrate; Carcinoma; Female; Fibrin Fibrinogen Degradation Products; Humans; Laparotomy; Ovarian Neoplasms; Peritoneal Lavage; Predictive Value of Tests; Reoperation; Sensitivity and Specificity; Tumor Markers, Biological


Cancer Biology | Cell and Developmental Biology | Oncology


Although serum CA-125 has improved our ability to monitor tumor response in ovarian carcinoma, approximately 50% of patients with normalization of CA-125 have persistent disease at second look laparotomy. Peritoneal CA-125 and plasma D-Dimer levels were studied to determine if their use could increase the sensitivity for persistent ovarian carcinoma in a population of patients with normal physical examinations, radiologic studies, and serum CA-125 values. Plasma D-Dimer levels were obtained prior to second look laparotomy. The results of peritoneal CA-125 and plasma D-Dimer studies were compared to second look laparotomy results. Differences were evaluated with a one-way analysis of variance. Twenty-seven patients were studied. Peritoneal CA-125 was evaluated in 23 patients and ranged from < 6.3-223 U/ml. There was no statistical difference in peritoneal CA-125 levels between patients whose second look laparotomies were negative, or microscopically or macroscopically positive. D-Dimer was elevated in three patients, all of whom had macroscopically positive second look findings. The sensitivity for positive second look findings was only 27%. Minimally elevated plasma D-Dimer levels were specific but not sensitive for persistent disease and peritoneal CA-125 was not predictive of disease status.


J Surg Oncol. 1994 Jul;56(3):168-71.

Journal/Book/Conference Title

Journal of surgical oncology

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