The E3 ubiquitin ligase Ro52 negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3
Authors
Higgs, RowanNi Gabhann, Joan
Ben Larbi, Nadia
Breen, Eamon P.
Fitzgerald, Katherine A.
Jefferies, Caroline A.
UMass Chan Affiliations
Department of Medicine, Division of Infectious Diseases and ImmunologyDocument Type
Journal ArticlePublication Date
2008-07-22Keywords
Cell LineDEAD-box RNA Helicases
Humans
Interferon Regulatory Factor-3
Interferon-beta
Polyubiquitin
Promoter Regions, Genetic
Protein Binding
Ribonucleoproteins
Signal Transduction
Toll-Like Receptor 3
Toll-Like Receptor 4
Ubiquitin-Protein Ligases
Immunology and Infectious Disease