Title

Integr-ating IL-1 alpha in antiviral host defenses

UMMS Affiliation

Department of Medicine, Division of Infectious Diseases and Immunology

Publication Date

7-17-2009

Document Type

Article

Subjects

Adenoviridae; Animals; Gene Therapy; Genetic Vectors; Immunity, Innate; Inflammation; Integrin beta3; Interleukin-1alpha; Mice

Disciplines

Immunology and Infectious Disease

Abstract

Adenoviral vectors used in gene therapy induce inflammation, although the underlying mechanisms are currently unknown. In this issue of Immunity, Di Paolo et al. (2009) implicate interleukin-1 alpha (IL- 1 alpha) in virus-induced inflammation and identify the beta 3 integrin as the key receptor regulating IL-1 alpha activity.

DOI of Published Version

10.1016/j.immuni.2009.07.001

Source

Immunity. 2009 Jul 17;31(1):7-9. Link to article on publisher's site

Journal/Book/Conference Title

Immunity

Related Resources

Link to Article in PubMed

PubMed ID

19604487