Integr-ating IL-1 alpha in antiviral host defenses
Department of Medicine, Division of Infectious Diseases and Immunology
Adenoviridae; Animals; Gene Therapy; Genetic Vectors; Immunity, Innate; Inflammation; Integrin beta3; Interleukin-1alpha; Mice
Immunology and Infectious Disease
Adenoviral vectors used in gene therapy induce inflammation, although the underlying mechanisms are currently unknown. In this issue of Immunity, Di Paolo et al. (2009) implicate interleukin-1 alpha (IL- 1 alpha) in virus-induced inflammation and identify the beta 3 integrin as the key receptor regulating IL-1 alpha activity.
DOI of Published Version
Immunity. 2009 Jul 17;31(1):7-9. Link to article on publisher's site
Fitzgerald KA. (2009). Integr-ating IL-1 alpha in antiviral host defenses. Infectious Diseases and Immunology Publications. https://doi.org/10.1016/j.immuni.2009.07.001. Retrieved from https://escholarship.umassmed.edu/infdis_pp/66