Catenin' on to nucleic acid sensing
Department of Medicine, Division of Infectious Diseases and Immunology
Catenins; Humans; Immunity, Innate; Interferon Regulatory Factor-3; Interferon Type I; Listeria monocytogenes; Protein-Serine-Threonine Kinases; RNA-Binding Proteins; Signal Transduction; Vesicular Stomatitis
Immunology and Infectious Disease
Many pathogens induce a type I interferon response via a pathway dependent on the kinase TBK1 and transcription factor IRF3. However, LRRFIP1, a cytosolic sensor of DNA and RNA, triggers interferon production by a β-catenin-dependent signal.
DOI of Published Version
Nat Immunol. 2010 Jun;11(6):466-8. Link to article on publisher's site
Rathinam VA, Sharma S, Fitzgerald KA. (2010). Catenin' on to nucleic acid sensing. Infectious Diseases and Immunology Publications. https://doi.org/10.1038/ni0610-466. Retrieved from https://escholarship.umassmed.edu/infdis_pp/50