Viral defense: it takes two MAVS to Tango
Department of Medicine, Division of Infectious Diseases and Immunology
Adaptor Proteins, Signal Transducing
Immunology and Infectious Disease
To defend cells against viruses, the MAVS (mitochondrial antiviral signaling) adaptor protein initiates an antiviral signaling cascade from mitochondrial membranes. In this issue, Dixit et al. (2010) show that MAVS also localizes to the membranes of peroxisomes, where it rapidly induces expression of a subset of antiviral genes that curb viral replication until mitochondrial MAVS can induce a sustained antiviral response.
DOI of Published Version
Cell. 2010 May 14;141(4):570-2. Link to article on publisher's site
Sharma S, Fitzgerald KA. (2010). Viral defense: it takes two MAVS to Tango. Infectious Diseases and Immunology Publications. https://doi.org/10.1016/j.cell.2010.04.043. Retrieved from https://escholarship.umassmed.edu/infdis_pp/49