UMMS Affiliation

Department of Medicine, Division of Infectious Diseases and Immunology

Publication Date

2010-04-22

Document Type

Article

Subjects

Cell Wall; Fungi; Mycoses

Disciplines

Immunology and Infectious Disease

Abstract

The emergence of fungal infections as major causes of morbidity and mortality in immunosuppressed individuals has prompted studies into how the host recognizes fungal pathogens. Fungi are eukaryotes and as such share many similarities with mammalian cells. The most striking difference, though, is the presence of a cell wall that serves to protect the fungus from environmental stresses, particularly osmotic changes [1]. This task is made challenging because the fungus must remodel itself to allow for cell growth and division, including the conversion to different morphotypes, such as occurs during germination of spherical spores into filamentous hyphae. The cell wall also connects the fungus with its environment by triggering intracellular signaling pathways and mediating adhesion to other cells and extracellular matrices. Here, important facts and concepts critical for understanding innate sensing of the fungal cell wall by mammalian pathogens are reviewed.

Rights and Permissions

Copyright: c2010 Stuart M. Levitz. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

DOI of Published Version

10.1371/journal.ppat.1000758

Source

Levitz SM (2010) Innate Recognition of Fungal Cell Walls. PLoS Pathog 6(4): e1000758. doi:10.1371/journal.ppat.1000758

Journal/Book/Conference Title

PLoS Pathogens

Related Resources

Link to article in PubMed

PubMed ID

20421940

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