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Department of Medicine, Division of Infectious Diseases and Immunology

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Document Type



Bacterial Infections and Mycoses | Infectious Disease


Long-term antibiotics are not effective for the therapy of patients with persistent symptoms and a history of Lyme disease. However, some clinicians still prescribe these therapies. We present a case of peripherally inserted central catheter-associated Nocardia nova endocarditis in a patient who had been receiving intravenous antibiotics for the management of chronic Lyme disease. This case highlights an important risk associated with the unscientific use of indwelling peripheral catheters and intravenous antibiotics for the management of such patients. Infectious Diseases Society of America.


Nocardia nova endocarditis, Peripherally Inserted Central Catheter-Associated infection, Persistent symptoms and a diagnosis of Lyme Disease

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© The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (, which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact

DOI of Published Version



Njie AB, Mitchell M, Pukkila-Worley R. Peripherally Inserted Central Catheter-Associated Nocardia nova Endocarditis in a Patient Receiving Intravenous Antibiotics for Chronic Lyme Disease. Open Forum Infect Dis. 2021 Mar 5;8(3):ofab041. doi: 10.1093/ofid/ofab041. PMID: 33728358; PMCID: PMC7944348. Link to article on publisher's site

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Open forum infectious diseases

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Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.