Caenorhabditis elegans in high-throughput screens for anti-infective compounds
Program in Innate Immunity, Department of Medicine, Division of Infectious Diseases and Immunology
Immunity | Immunology of Infectious Disease | Immunopathology | Infectious Disease | Microbiology
New classes of antimicrobials that are effective therapies for infections with multi-drug resistant pathogens are urgently needed. The nematode Caenorhabditis elegans has been incorporated into small molecule screening platforms to identify anti-infective compounds that provide protection of a host during infection. The use of a live animal in these screening systems offers several advantages, including the ability to identify molecules that boost innate immune responses in a manner advantageous to host survival and compounds that disrupt bacterial virulence mechanisms. In addition, new classes of antimicrobials that target the pathogen have been uncovered, as well as interesting chemical probes that can be used to dissect new mechanisms of host-pathogen interactions.
DOI of Published Version
Peterson ND, Pukkila-Worley R. Caenorhabditis elegans in high-throughput screens for anti-infective compounds. Curr Opin Immunol. 2018 Oct;54:59-65. doi: 10.1016/j.coi.2018.06.003. Epub 2018 Jun 20. PMID: 29935375; PMCID: PMC6463281. Link to article on publisher's site
Current opinion in immunology
Peterson ND, Pukkila-Worley R. (2018). Caenorhabditis elegans in high-throughput screens for anti-infective compounds. Infectious Diseases and Immunology Publications. https://doi.org/10.1016/j.coi.2018.06.003. Retrieved from https://escholarship.umassmed.edu/infdis_pp/426