The Kinase IKKbeta Regulates a STING- and NF-kappaB-Dependent Antiviral Response Pathway in Drosophila
Department of Medicine, Division of Infectious Diseases and Immunology
Immunity | Immunology of Infectious Disease | Virology
Antiviral immunity in Drosophila involves RNA interference and poorly characterized inducible responses. Here, we showed that two components of the IMD pathway, the kinase dIKKbeta and the transcription factor Relish, were required to control infection by two picorna-like viruses. We identified a set of genes induced by viral infection and regulated by dIKKbeta and Relish, which included an ortholog of STING. We showed that dSTING participated in the control of infection by picorna-like viruses, acting upstream of dIKKbeta to regulate expression of Nazo, an antiviral factor. Our data reveal an antiviral function for STING in an animal model devoid of interferons and suggest an evolutionarily ancient role for this molecule in antiviral immunity.
19orf12, Dicistrovirus, Drosophila melanogaster, IKKβ, IMD pathway, NF-κB, STING, antiviral immunity, innate immunity, picornavirus
DOI of Published Version
Goto A, Okado K, Martins N, Cai H, Barbier V, Lamiable O, Troxler L, Santiago E, Kuhn L, Paik D, Silverman N, Holleufer A, Hartmann R, Liu J, Peng T, Hoffmann JA, Meignin C, Daeffler L, Imler JL. The Kinase IKKβ Regulates a STING- and NF-κB-Dependent Antiviral Response Pathway in Drosophila. Immunity. 2018 Aug 21;49(2):225-234.e4. doi: 10.1016/j.immuni.2018.07.013. Epub 2018 Aug 14. Erratum in: Immunity. 2020 Jan 14;52(1):200. PMID: 30119996; PMCID: PMC6267954. Link to article on publisher's site
Goto A, Okado K, Paik D, Silverman NS, Imler J. (2018). The Kinase IKKbeta Regulates a STING- and NF-kappaB-Dependent Antiviral Response Pathway in Drosophila. Infectious Diseases and Immunology Publications. https://doi.org/10.1016/j.immuni.2018.07.013. Retrieved from https://escholarship.umassmed.edu/infdis_pp/423