A Sugar Rush for Innate Immunity
Department of Medicine, Division of Infectious Diseases and Immunology
Immunity | Microbiology
Early detection of microbial patterns is a hallmark of innate immunity and essential for clearance of invading pathogens. A recent Nature publication by Zhou et al. (2018) has uncovered ALPK1 as a pattern recognition receptor for Gram-negative bacteria triggering NF-kappaB activation and identified the bacterial sugar ADP-Hep as its ligand.
DOI of Published Version
Orning P, Flo TH, Lien E. A Sugar Rush for Innate Immunity. Cell Host Microbe. 2018 Oct 10;24(4):461-463. doi: 10.1016/j.chom.2018.09.017. PMID: 30308148; PMCID: PMC6510543. Link to article on publisher's site
Cell host and microbe
Orning MA, Flo TH, Lien E. (2018). A Sugar Rush for Innate Immunity. Infectious Diseases and Immunology Publications. https://doi.org/10.1016/j.chom.2018.09.017. Retrieved from https://escholarship.umassmed.edu/infdis_pp/421