Title

A Sugar Rush for Innate Immunity

UMMS Affiliation

Department of Medicine, Division of Infectious Diseases and Immunology

Publication Date

2018-10-10

Document Type

Article

Disciplines

Immunity | Microbiology

Abstract

Early detection of microbial patterns is a hallmark of innate immunity and essential for clearance of invading pathogens. A recent Nature publication by Zhou et al. (2018) has uncovered ALPK1 as a pattern recognition receptor for Gram-negative bacteria triggering NF-kappaB activation and identified the bacterial sugar ADP-Hep as its ligand.

DOI of Published Version

10.1016/j.chom.2018.09.017

Source

Orning P, Flo TH, Lien E. A Sugar Rush for Innate Immunity. Cell Host Microbe. 2018 Oct 10;24(4):461-463. doi: 10.1016/j.chom.2018.09.017. PMID: 30308148; PMCID: PMC6510543. Link to article on publisher's site

Journal/Book/Conference Title

Cell host and microbe

Related Resources

Link to Article in PubMed

PubMed ID

30308148

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