Title

MUC1 mucin is a negative regulator of toll-like receptor signaling

UMMS Affiliation

Department of Medicine, Division of Infectious Disease & Immunology

Publication Date

2008-03-01

Document Type

Article

Disciplines

Immunity | Immunology and Infectious Disease | Immunology of Infectious Disease | Infectious Disease | Virology

Abstract

MUC1 (MUC1 in humans and Muc1 in nonhuman species) is a transmembrane mucin-like glycoprotein expressed in epithelial cells lining various mucosal surfaces as well as hematopoietic cells. Recently, we showed that Muc1(-/-) mice exhibited greater inflammatory responses to Pseudomonas aeruginosa or its flagellin compared with their wild-type littermates, and our studies with cultured cells revealed that MUC1/Muc1 suppressed the Toll-like receptor (TLR) 5 signaling pathway, suggesting its anti-inflammatory role. Here we demonstrate that other TLR signaling (TLR2, 3, 4, 7, and 9) is also suppressed by MUC1/Muc1. The results from this study suggest that MUC1/Muc1 may play a crucial role during airway infection and inflammation by various pathogenic bacteria and viruses.

DOI of Published Version

10.1165/rcmb.2007-0336RC

Source

Am J Respir Cell Mol Biol. 2008 Mar;38(3):263-8. Epub 2007 Dec 13. Link to article on publisher's site

Journal/Book/Conference Title

American journal of respiratory cell and molecular biology

Related Resources

Link to Article in PubMed

PubMed ID

18079492

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