MUC1 mucin is a negative regulator of toll-like receptor signaling
Department of Medicine, Division of Infectious Disease & Immunology
Immunity | Immunology and Infectious Disease | Immunology of Infectious Disease | Infectious Disease | Virology
MUC1 (MUC1 in humans and Muc1 in nonhuman species) is a transmembrane mucin-like glycoprotein expressed in epithelial cells lining various mucosal surfaces as well as hematopoietic cells. Recently, we showed that Muc1(-/-) mice exhibited greater inflammatory responses to Pseudomonas aeruginosa or its flagellin compared with their wild-type littermates, and our studies with cultured cells revealed that MUC1/Muc1 suppressed the Toll-like receptor (TLR) 5 signaling pathway, suggesting its anti-inflammatory role. Here we demonstrate that other TLR signaling (TLR2, 3, 4, 7, and 9) is also suppressed by MUC1/Muc1. The results from this study suggest that MUC1/Muc1 may play a crucial role during airway infection and inflammation by various pathogenic bacteria and viruses.
DOI of Published Version
American journal of respiratory cell and molecular biology
Ueno K, Koga T, Kato K, Golenbock DT, Gendler SJ, Kai H, Kim KC. (2008). MUC1 mucin is a negative regulator of toll-like receptor signaling. Infectious Diseases and Immunology Publications. https://doi.org/10.1165/rcmb.2007-0336RC. Retrieved from https://escholarship.umassmed.edu/infdis_pp/401