Title

Beyond empiricism: informing vaccine development through innate immunity research

UMMS Affiliation

Department of Medicine, Division of Infectious Diseases and Immunology

Publication Date

2012-03-16

Document Type

Article

Disciplines

Immunity | Immunology of Infectious Disease | Immunoprophylaxis and Therapy | Infectious Disease

Abstract

Although a great public heath success, vaccines provide suboptimal protection in some patient populations and are not available to protect against many infectious diseases. Insights from innate immunity research have led to a better understanding of how existing vaccines work and have informed vaccine development. New adjuvants and delivery systems are being designed based upon their capacity to stimulate innate immune sensors and target antigens to dendritic cells, the cells responsible for initiating adaptive immune responses. Incorporating these adjuvants and delivery systems in vaccines can beneficially alter the quantitative and qualitative nature of the adaptive immune response, resulting in enhanced protection.

DOI of Published Version

10.1016/j.cell.2012.02.012

Source

Cell. 2012 Mar 16;148(6):1284-92. doi: 10.1016/j.cell.2012.02.012. Link to article on publisher's site

Journal/Book/Conference Title

Cell

Related Resources

Link to Article in PubMed

PubMed ID

22424235

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