Recovery from a viral respiratory tract infection. IV. Specificity of protection by cytotoxic T lymphocytes
Center for Infectious Disease and Vaccine Research; Department of Medicine, Division of Infectious Diseases and Immunology
Immunity | Immunology and Infectious Disease | Immunology of Infectious Disease | Infectious Disease | Virology
Immune spleen cells enhanced for influenza-specific cytotoxic activity after exposure to virus-infected stimulator cells in vitro effect recovery when transferred to nude and immunocompetent mice with influenza pneumonia (5). This protective effect correlated with the virus-specific cytotoxic activity of the transferred lymphocytes and is removed by treatment with anti-0 serum and complement. The experiments presented here indicate that spleen cells taken directly from mice undergoing a primary or secondary infection are less protective than immune spleen cells that are restimulated in vitro before transfer. This decreased ability to clear pulmonary virus and effect survival correlated with their relatively lower levels of influenza-specific cytotoxicity. Protection did not correlate with the level of natural killer cell activity of transferred cells. The results also indicate the immune spleen cells that are protective are influenza A subtype cross-reactive and are H-2-restricted; H-2d immune spleen cells effected recovery of H-2d but not H-2k challenged mice.
J Immunol. 1983 Jun;130(6):2908-14.
Journal of immunology (Baltimore, Md. : 1950)
Wells, Martha A.; Daniel, Sylvester; Djeu, Julia Y.; Kiley, Susan C.; and Ennis, Francis A., "Recovery from a viral respiratory tract infection. IV. Specificity of protection by cytotoxic T lymphocytes" (1983). Infectious Diseases and Immunology Publications and Presentations. 351.