Protective cross-reactive epitope on the nonstructural protein NS1 of influenza A virus
Center for Infectious Disease and Vaccine Research; Department of Medicine, Division of Infectious Diseases and Immunology
Immunity | Immunology and Infectious Disease | Immunology of Infectious Disease | Infectious Disease | Virology
We reported previously that adoptive immunization with an influenza A virus NS1-specific H-2Ld-restricted, cross-reactive, CTL clone A-11 established by stimulation with A/PR/8/34 virus (H1N1) reduced lung virus titers in mice challenged with virus in vivo (Virology 178:174-179, 1990). Using a set of recombinant vaccinia virus constructs containing truncated portions of the NS gene we have localized this cross-protective CTL epitope to the N-terminal region of the NS1 protein. This region of NS1 is active in inducing CD8+ CTL in vivo because virus-stimulated BALB/c immune spleen cells in bulk cultures also recognized the N-terminal region of the NS1 protein.
DOI of Published Version
Viral Immunol. 1993 Winter;6(4):229-36. Link to article on publisher's site
Saikh, Kamal U.; Tamura, Manabu; Kuwano, Koichi; Dai, Li-Chen C.; West, Kim; and Ennis, Francis A., "Protective cross-reactive epitope on the nonstructural protein NS1 of influenza A virus" (1993). Infectious Diseases and Immunology Publications and Presentations. 326.