Cytotoxic T lymphocytes in dengue virus infection
Center for Infectious Disease and Vaccine Research; Department of Medicine, Division of Infectious Diseases and Immunology
Immunity | Immunology and Infectious Disease | Immunology of Infectious Disease | Infectious Disease | Virology
Dengue viruses are members of the family Flaviviridae and there are four serotypes, dengue virus types 1, 2, 3, and 4. The genome of dengue viruses consists of a single-stranded RNA nearly 11 kb in length which is plusstranded and infectious (RICE et al. 1986). Dengue virus genome codes for three structural proteins, capsid (C), PreM, which is a precursor to membrane (M), and envelope (E), and seven nonstructural proteins, NS1, NS2a, NS2b, NS3, NS4a, NS4b, and NS5 (Zhao et al. 1986; Mackow et al. 1987; Henchal and Putnak 1990). The functions of these proteins are not clearly understood. NS3 protein has been reported to have protease activity (Preugshat et al. 1990) and also contains conserved epitopes characteristic of helicases (Golbalenya et al. 1989). The virion consists of RNA genome surrounded by a lipid bilayer containing E and M proteins. Dengue viruses infect monocytes and other macrophages (Halstead et al. 1977), B lymphoblastoid cells (Sung et al. 1975; Theofilopoulos et al. 1976), T cell tumor lines (Kurane et al. 1990), epithelial cells (Smithand Wright1985), fibroblasts (Kurane et al. 1992), and endothelial cells (Andrews et al. 1978) in vitro. However, it is believed that in vivo monocytes and other macrophages are the important source of dengue virus replication (Halstead et al. 1977; Boonpucknavig et al. 1976, 1979).
Curr Top Microbiol Immunol. 1994;189:93-108.
Current topics in microbiology and immunology
Kurane, Ichiro and Ennis, Francis A., "Cytotoxic T lymphocytes in dengue virus infection" (1994). Infectious Diseases and Immunology Publications and Presentations. 321.