Immunologic responses to vaccinia vaccines administered by different parenteral routes
Center for Infectious Disease and Vaccine Research; Department of Medicine, Division of Infectious Diseases and Immunology
Immunity | Immunology and Infectious Disease | Immunology of Infectious Disease | Infectious Disease
To develop a less reactogenic but equally immunogenic vaccine, this study of 91 human volunteers compared the safety and immunogenic potency of a new, cell culture-derived vaccinia virus vaccine administered intradermally and intramuscularly with the licensed vaccinia vaccine administered by scarification. Cutaneous pox lesions developed in a higher proportion of scarification vaccinees. Scarification and intradermal vaccine recipients who developed cutaneous pox lesions had more local reactions but also achieved significantly higher cell-mediated and neutralizing antibody responses than those who did not develop pox lesions. Although less reactogenic, intradermal or intramuscular administration of vaccinia vaccine without the concomitant development of a cutaneous pox lesion induced lower immune responses.
DOI of Published Version
J Infect Dis. 1997 Apr;175(4):756-63. DOI: 10.1086/513968
The Journal of infectious diseases
McClain DJ, Harrison S, Yeager CL, Cruz J, Ennis FA, Gibbs P, Wright MS, Summers PL, Arthur JD, Graham JA. (1997). Immunologic responses to vaccinia vaccines administered by different parenteral routes. Infectious Diseases and Immunology Publications. https://doi.org/10.1086/513968. Retrieved from https://escholarship.umassmed.edu/infdis_pp/307