Early immune activation in acute dengue illness is related to development of plasma leakage and disease severity
Authors
Green, SharoneVaughn, D. W.
Kalayanarooj, Siripen
Nimmannitaya, Suchitra
Suntayakorn, Saroj
Nisalak, Ananda
Lew, Robert
Innis, B. L.
Kurane, Ichiro
Rothman, Alan L.
Ennis, Francis A.
UMass Chan Affiliations
Center for Infectious Disease and Vaccine ResearchDocument Type
Journal ArticlePublication Date
1999-04-01Keywords
ImmunityImmunology and Infectious Disease
Immunology of Infectious Disease
Infectious Disease
Metadata
Show full item recordAbstract
T lymphocyte activation and increased cytokine levels have been described in retrospective studies of children presenting with dengue hemorrhagic fever (DHF). Serial plasma samples obtained in a prospective study of Thai children presenting with (sTNFRs) were higher in children who developed DHF than in those with dengue fever (DF) or other nondengue febrile illnesses (OFIs) and were correlated with the degree of subsequent plasma leakage. Soluble CD8 and soluble interleukin-2 receptor levels were also elevated in children with DHF compared with those with DF. Interferon-gamma and sTNFR 60-kDa levels were higher in children with dengue than in those with OFIs. TNF-alpha was detectable more often in DHF than in DF or OFIs (P < .05). These results support the hypothesis that immune activation contributes to the pathogenesis of DHF. Further studies evaluating the predictive value of sTNFR80 for DHF are warranted.Source
J Infect Dis. 1999 Apr;179(4):755-62. Link to article on publisher's siteDOI
10.1086/314680Permanent Link to this Item
http://hdl.handle.net/20.500.14038/35083PubMed ID
10068569Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1086/314680