Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity
Center for Infectious Disease and Vaccine Research; Department of Medicine, Division of Infectious Diseases and Immunology
Immunity | Immunology and Infectious Disease | Immunology of Infectious Disease | Infectious Disease
Viremia titers in serial plasma samples from 168 children with acute dengue virus infection who were enrolled in a prospective study at 2 hospitals in Thailand were examined to determine the role of virus load in the pathogenesis of dengue hemorrhagic fever (DHF). The infecting virus serotype was identified for 165 patients (DEN-1, 46 patients; DEN-2, 47 patients; DEN-3, 47 patients, DEN-4, 25 patients). Patients with DEN-2 infections experienced more severe disease than those infected with other serotypes. Eighty-one percent of patients experienced a secondary dengue virus infection that was associated with more severe disease. Viremia titers were determined for 41 DEN-1 and 46 DEN-2 patients. Higher peak titers were associated with increased disease severity for the 31 patients with a peak titer identified (mean titer of 107.6 for those with dengue fever vs. 108.5 for patients with DHF, P=.01). Increased dengue disease severity correlated with high viremia titer, secondary dengue virus infection, and DEN-2 virus type.
DOI of Published Version
J Infect Dis. 2000 Jan;181(1):2-9. Link to article on publisher's site
The Journal of infectious diseases
Vaughn, D. W.; Green, Sharone; Kalayanarooj, Siripen; Innis, B. L.; Nimmannitaya, Suchitra; Suntayakorn, Saroj; Endy, Timothy P.; Raengsakulrach, B; Rothman, Alan L.; Ennis, Francis A.; and Nisalak, Ananda, "Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity" (2000). Infectious Diseases and Immunology Publications and Presentations. 288.