Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity
Center for Infectious Disease and Vaccine Research; Department of Medicine, Division of Infectious Diseases and Immunology
Immunity | Immunology and Infectious Disease | Immunology of Infectious Disease | Infectious Disease
Viremia titers in serial plasma samples from 168 children with acute dengue virus infection who were enrolled in a prospective study at 2 hospitals in Thailand were examined to determine the role of virus load in the pathogenesis of dengue hemorrhagic fever (DHF). The infecting virus serotype was identified for 165 patients (DEN-1, 46 patients; DEN-2, 47 patients; DEN-3, 47 patients, DEN-4, 25 patients). Patients with DEN-2 infections experienced more severe disease than those infected with other serotypes. Eighty-one percent of patients experienced a secondary dengue virus infection that was associated with more severe disease. Viremia titers were determined for 41 DEN-1 and 46 DEN-2 patients. Higher peak titers were associated with increased disease severity for the 31 patients with a peak titer identified (mean titer of 107.6 for those with dengue fever vs. 108.5 for patients with DHF, P=.01). Increased dengue disease severity correlated with high viremia titer, secondary dengue virus infection, and DEN-2 virus type.
DOI of Published Version
J Infect Dis. 2000 Jan;181(1):2-9. Link to article on publisher's site
The Journal of infectious diseases
Vaughn DW, Green S, Kalayanarooj S, Innis BL, Nimmannitaya S, Suntayakorn S, Endy TP, Raengsakulrach B, Rothman AL, Ennis FA, Nisalak A. (2000). Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity. Infectious Diseases and Immunology Publications. https://doi.org/10.1086/315215. Retrieved from https://escholarship.umassmed.edu/infdis_pp/288