Induction of T lymphocyte responses to dengue virus by a candidate tetravalent live attenuated dengue virus vaccine
Center for Infectious Disease and Vaccine Research; Department of Medicine, Division of Infectious Diseases and Immunology
Immunity | Immunology and Infectious Disease | Immunology of Infectious Disease | Infectious Disease
Development of a safe and immunogenic tetravalent dengue virus (DV) vaccine has been designated as a priority by the World Health Organization. We characterized the T cell response to DV induced by a candidate live attenuated tetravalent DV vaccine as part of a phase I study. Proliferation and cytotoxic T lymphocyte (CTL) responses to multiple DV serotypes were detected in six of six and four of four subjects studied, respectively. Proliferation responses were higher to DV serotypes 1 and 3 than to serotypes 2 and 4. CTL responses were higher to DV serotypes 2 and 3 than to serotype 1, and included serotype cross-reactive responses. Production of interferon-gamma, but not IL-4, was observed in response to DV stimulation. This candidate vaccine is immunogenic for both CD4+ and CD8+ T lymphocytes. However, T cell responses to the four DV serotypes were not equivalent, suggesting that the vaccine could be further optimized.
DOI of Published Version
Vaccine. 2001 Sep 14;19(32):4694-9. doi:10.1016/S0264-410X(01)00236-5
Rothman, Alan L.; Kanesa-thasan, N.; West, Kim; Janus, Jurand; Saluzzo, Jean-Francois; and Ennis, Francis A., "Induction of T lymphocyte responses to dengue virus by a candidate tetravalent live attenuated dengue virus vaccine" (2001). Infectious Diseases and Immunology Publications and Presentations. 285.