MIP-1 alpha and MIP-1 beta induction by dengue virus
Center for Infectious Disease and Vaccine Research; Department of Medicine, Division of Infectious Diseases and Immunology
Immunity | Immunology and Infectious Disease | Immunology of Infectious Disease | Infectious Disease | Medical Immunology | Virology
Dengue virus (DV) infection can result in either a mild febrile illness known as dengue fever (DF) or a life-threatening disease called dengue hemorrhagic fever (DHF). DHF is more prevalent in patients undergoing secondary DV infection. This observation has led to the hypothesis that DHF may be the result of immune reactions to the secondary DV infection; an event termed immunopathology. Two cellular factors, MIP-1 alpha and MIP-1 beta, have been found to be induced by infection with DV. MIP-1 induction by DV infection was observed in a myelomonocytic cell line, as well as in peripheral blood mononuclear cells isolated from a dengue naive donor. MIP-1 induction was not due to factors secreted by infected cells. In fact, replication-competent virus was required to induce MIP-1. Evidence is also provided that MIP-1 genes are expressed in patients with dengue disease. It is hypothesized that these chemokines may have roles in the immunopathology of dengue infections and may contribute to fever and bone marrow suppression observed in patients with DV infections.
DOI of Published Version
J Med Virol. 2001 Oct;65(2):324-30. doi:10.1002/jmv.2037
Journal of medical virology
Spain-Santana, Tammy A.; Marglin, Stephanie; Ennis, Francis A.; and Rothman, Alan L., "MIP-1 alpha and MIP-1 beta induction by dengue virus" (2001). Infectious Diseases and Immunology Publications and Presentations. 284.