Cellular immune activation in children with acute dengue virus infections is modulated by apoptosis
Department of Medicine, Division of Infectious Diseases and Immunology; Center for Infectious Disease and Vaccine Research
Immunity | Immunology and Infectious Disease | Immunology of Infectious Disease | Infectious Disease
Apoptosis is an important modulator of cellular immune responses during systemic viral infections. Peripheral-blood mononuclear cell (PBMC) apoptosis and plasma soluble levels of CD95, a mediator of apoptosis, were determined in sequential samples from children participating in a prospective study of dengue virus (DV) infections. During the period of defervescence, levels of PBMC apoptosis were higher in children developing dengue hemorrhagic fever (DHF), the most severe form of illness, than in those with dengue fever (DF) and other, nondengue, febrile illnesses. CD8(+) T lymphocytes made up approximately half of the peak circulating apoptotic PBMCs in DHF and DF. Maximum plasma levels of soluble CD95 were also higher in children with DHF than in those with DF. The level of PBMC apoptosis correlated with dengue disease severity. Apoptosis appears to be involved in modulation of the innate and adaptive immune responses to DV infection and is likely involved in the evolution of immune responses in other viral hemorrhagic fevers.
DOI of Published Version
J Infect Dis. 2006 Sep 1;194(5):600-7. Epub 2006 Jul 31. DOI: 10.1086/506451 Link to article on publisher's site
The Journal of infectious diseases
Myint, Khin S.; Endy, Timothy P.; Mongkolsirichaikul, Duangrat; Manomuth, Choompun; Kalayanarooj, Siripen; Vaughn, David W.; Nisalak, Ananda; Green, Sharone; Rothman, Alan L.; Ennis, Francis A.; and Libraty, Daniel H., "Cellular immune activation in children with acute dengue virus infections is modulated by apoptosis" (2006). Infectious Diseases and Immunology Publications and Presentations. 259.