A role for the mevalonate pathway in the induction of subtype cross-reactive immunity to influenza A virus by human gammadelta T lymphocytes
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UMass Chan Affiliations
Division of Infectious Diseases and Immunology, Department of MedicineCenter for Infectious Disease and Vaccine Research
Document Type
Journal ArticlePublication Date
2010-05-04Keywords
ImmunityImmunology and Infectious Disease
Immunology of Infectious Disease
Infectious Disease
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Show full item recordAbstract
The major gammadelta T cell subset in the human peripheral blood expresses the Vgamma9delta2 TCR and recognizes non-peptidic prenyl pyrophosphate antigens such as isopentylpyrophosphate (IPP). Upon activation the gammadelta T cells rapidly secrete antiviral cytokines similar to classical memory alphabeta T cells. Here we have investigated the ability of gammadelta T lymphocytes from human PBMC to become activated by influenza A virus infection. Vgamma9Vdelta2 T lymphocytes rapidly upregulate expression of CD25 and CD69 and produce IFN-gamma following influenza infection of PBMC. Moreover, the recognition is cross-reactive between various subtypes of influenza, but not with vaccinia virus. Vgamma9Vdelta2 T cell responses are potently reduced by the HMG-CoA reductase inhibitor mevastatin, which inhibits the mevalonate pathway and IPP synthesis. Our results indicate that influenza virus infection induces the rapid activation and function of Vgamma9Vdelta2 T lymphocytes in the peripheral blood via a mechanism that depends on the mevalonate pathway.Source
Cell Immunol. 2010;264(1):71-7. doi: 10.1016/j.cellimm.2010.04.013. Epub 2010 May 4. Link to article on publisher's siteDOI
10.1016/j.cellimm.2010.04.013Permanent Link to this Item
http://hdl.handle.net/20.500.14038/35026PubMed ID
20483407Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.cellimm.2010.04.013