Center for Infectious Disease and Vaccine Research; Division of Infectious Diseases and Immunology, Department of Medicine
Immunity | Immunology and Infectious Disease | Immunology of Infectious Disease | Infectious Disease
We characterized human monoclonal antibodies (MAbs) cloned from influenza virus-infected patients and from influenza vaccine recipients by complement-dependent lysis (CDL) assay. Most MAbs active in CDL were neutralizing, but not all neutralizing MAbs can mediate CDL. Two of the three stalk-specific neutralizing MAbs tested were able to mediate CDL and were more cross-reactive to temporally distant H1N1 strains than the conventional hemagglutination-inhibiting and neutralizing MAbs. One of the stalk-specific MAbs was subtype cross-reactive to H1 and H2 hemagglutinins, suggesting a role for stalk-specific antibodies in protection against influenza illness, especially by a novel viral subtype which can cause pandemics.
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DOI of Published Version
J Virol. 2011 Dec;85(24):13463-7. doi: 10.1128/JVI.05193-11. Epub 2011 Oct 12. Link to article on publisher's site
Journal of virology
Terajima M, Cruz J, Co MT, Lee J, Kaur K, Wrammert J, Wilson PC, Ennis FA. (2011). Complement-dependent lysis of influenza a virus-infected cells by broadly cross-reactive human monoclonal antibodies. Infectious Diseases and Immunology Publications. https://doi.org/10.1128/JVI.05193-11. Retrieved from https://escholarship.umassmed.edu/infdis_pp/238