The Significance of Isolated Antibody to Hepatitis B Core Antigen Seropositivity in Patients Infected with Human Immunodeficiency Virus

UMMS Affiliation

Department of Medicine, Division of Infectious Diseases and Immunology

Publication Date


Document Type



Immunity | Immunology of Infectious Disease | Infectious Disease


To decrease transmission of hepatitis B virus (HBV), immunization with the HBV vaccine has been recommended for individuals in high-risk populations who are seronegative for antibodies to hepatitis B [1]. Isolated antibody to hepatitis B core antigen (antiHBc) seropositivity is found in about 2.5% of volunteer blood donors in the United States and is often considered a false-positive serological response [2]. However, in a retrospective review of HIV-infected patients in Worcester, Massachusetts, we unexpectedly noted isolated anti-HBc seropositivity in > 30% of our population. To gain insight into the meaning of the isolated anti-HBc seropositivity, we further analyzed this patient population.

DOI of Published Version



Davaro RE, Cheeseman SH, Keroack MA, Ellison RT III. The significance of isolated anti-HBc seropositivity in patients infected with HIV. Clin Infect Dis 1996;23:189-190. doi: 10.1093/clinids/23.1.189. Link to article on publisher's site

Journal/Book/Conference Title

Clinical Infectious Diseases