Statistical evaluation of the role of Helicobacter pylori in stress gastritis: applications of splines and bootstrapping to the logistic model

UMMS Affiliation

Department of Medicine, Division of Infectious Diseases and Immunology

Publication Date


Document Type



Aged; Antibodies, Bacterial; Enzyme-Linked Immunosorbent Assay; Female; Gastritis; Gastrointestinal Hemorrhage; Helicobacter Infections; Helicobacter pylori; Humans; Immunoglobulin A; Immunoglobulin G; Intensive Care Units; Logistic Models; Male; Middle Aged; ROC Curve; Risk Factors; Stress, Psychological


Bacterial Infections and Mycoses | Clinical Epidemiology | Digestive System Diseases | Infectious Disease


Stress gastritis is a serious problem in the intensive care unit population. The recent discovery of the causal nature of Helicobacter pylori (H. pylori) in the development of gastric ulcers led us to examine its relationship with stress gastritis. We investigated this relationship in 874 veterans admitted to intensive care units who were tested for the presence of H. pylori and followed for 6 weeks for the development of stress gastritis. We fit spline models to assess functional relationships and used the logistic model to determine the association between H. pylori and stress gastritis. The predictive ability of the model was assessed with receiver operating characteristic (ROC) curve analysis and validated with the bootstrapping technique. Increased anti-H. pylori immunoglobulin A concentrations were found to be an important predictor of stress gastritis independent of other known risk factors.

DOI of Published Version



J Clin Epidemiol. 1997 Nov;50(11):1273-9. doi:10.1016/S0895-4356(97)00180-7

Journal/Book/Conference Title

Journal of clinical epidemiology

Related Resources

Link to Article in PubMed

PubMed ID