Citrobacter rodentium: infection, inflammation and the microbiota
Authors
Collins, James W.Keeney, Kristie M.
Crepin, Valerie F.
Rathinam, Vijay A. K.
Fitzgerald, Katherine A.
Finlay, B. Brett
Frankel, Gad
UMass Chan Affiliations
Department of Medicine, Division of Infectious Diseases and ImmunologyDocument Type
Journal ArticlePublication Date
2014-09-01Keywords
AnimalsCitrobacter rodentium
Colitis
Colon
Diet
Enterobacteriaceae Infections
Enterohemorrhagic Escherichia coli
Enteropathogenic Escherichia coli
Epithelium
*Host-Pathogen Interactions
Immunity, Mucosal
Intestine, Large
Mice
*Microbiota
Signal Transduction
Virulence
Bacteria
Digestive System
Immunity
Immunology and Infectious Disease
Immunology of Infectious Disease
Infectious Disease
Pathogenic Microbiology
Metadata
Show full item recordAbstract
Citrobacter rodentium is a mucosal pathogen of mice that shares several pathogenic mechanisms with enteropathogenic Escherichia coli (EPEC) and enterohaemorrhagic E. coli (EHEC), which are two clinically important human gastrointestinal pathogens. Thus, C. rodentium has long been used as a model to understand the molecular basis of EPEC and EHEC infection in vivo. In this Review, we discuss recent studies in which C. rodentium has been used to study mucosal immunology, including the deregulation of intestinal inflammatory responses during bacteria-induced colitis and the role of the intestinal microbiota in mediating resistance to colonization by enteric pathogens. These insights should help to elucidate the roles of mucosal inflammatory responses and the microbiota in the virulence of enteric pathogens.Source
Nat Rev Microbiol. 2014 Sep;12(9):612-23. doi: 10.1038/nrmicro3315. Epub 2014 Aug 4. Link to article on publisher's siteDOI
10.1038/nrmicro3315Permanent Link to this Item
http://hdl.handle.net/20.500.14038/34944PubMed ID
25088150Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1038/nrmicro3315