Long non-coding RNAs and control of gene expression in the immune system
Department of Medicine, Division of Infectious Diseases and Immunology, Program in Innate Immunity
Genetic Processes | Immunity | Immunology and Infectious Disease | Immunology of Infectious Disease | Infectious Disease | Molecular Biology | Molecular Genetics
All cells of the immune system rely on a highly integrated and dynamic gene expression program that is controlled by both transcriptional and post-transcriptional mechanisms. Recently, non-coding RNAs, including long non-coding RNAs (lncRNAs), have emerged as important regulators of gene expression in diverse biological contexts. lncRNAs control gene expression in the nucleus by modulating transcription or via post-transcriptional mechanisms targeting the splicing, stability, or translation of mRNAs. Our knowledge of lncRNA biogenesis, their cell type-specific expression, and their versatile molecular functions is rapidly progressing in all areas of biology. We discuss here these exciting new regulators and highlight an emerging paradigm of lncRNA-mediated control of gene expression in the immune system.
DOI of Published Version
Trends Mol Med. 2014 Nov;20(11):623-631. doi: 10.1016/j.molmed.2014.09.002. Epub 2014 Sep 25. Link to article on publisher's site
Trends in molecular medicine
Atianand MK, Fitzgerald KA. (2014). Long non-coding RNAs and control of gene expression in the immune system. Infectious Diseases and Immunology Publications. https://doi.org/10.1016/j.molmed.2014.09.002. Retrieved from https://escholarship.umassmed.edu/infdis_pp/164