Long non-coding RNAs and control of gene expression in the immune system

UMMS Affiliation

Department of Medicine, Division of Infectious Diseases and Immunology, Program in Innate Immunity

Publication Date


Document Type



Genetic Processes | Immunity | Immunology and Infectious Disease | Immunology of Infectious Disease | Infectious Disease | Molecular Biology | Molecular Genetics


All cells of the immune system rely on a highly integrated and dynamic gene expression program that is controlled by both transcriptional and post-transcriptional mechanisms. Recently, non-coding RNAs, including long non-coding RNAs (lncRNAs), have emerged as important regulators of gene expression in diverse biological contexts. lncRNAs control gene expression in the nucleus by modulating transcription or via post-transcriptional mechanisms targeting the splicing, stability, or translation of mRNAs. Our knowledge of lncRNA biogenesis, their cell type-specific expression, and their versatile molecular functions is rapidly progressing in all areas of biology. We discuss here these exciting new regulators and highlight an emerging paradigm of lncRNA-mediated control of gene expression in the immune system.

DOI of Published Version



Trends Mol Med. 2014 Nov;20(11):623-631. doi: 10.1016/j.molmed.2014.09.002. Epub 2014 Sep 25. Link to article on publisher's site

Journal/Book/Conference Title

Trends in molecular medicine

Related Resources

Link to Article in PubMed

PubMed ID