Innate sensing of malaria parasites

UMMS Affiliation

Department of Medicine, Division of Infectious Diseases and Immunology

Publication Date


Document Type



Immunity | Immunology and Infectious Disease | Immunology of Infectious Disease | Infectious Disease | Parasitic Diseases | Pathogenic Microbiology


Innate immune receptors have a key role in immune surveillance by sensing microorganisms and initiating protective immune responses. However, the innate immune system is a classic 'double-edged sword' that can overreact to pathogens, which can have deleterious effects and lead to clinical manifestations. Recent studies have unveiled the complexity of innate immune receptors that function as sensors of Plasmodium spp. in the vertebrate host. This Review highlights the cellular and molecular mechanisms by which Plasmodium infection is sensed by different families of innate immune receptors. We also discuss how these events mediate both host resistance to infection and the pathogenesis of malaria.

DOI of Published Version



Nat Rev Immunol. 2014 Nov;14(11):744-57. doi: 10.1038/nri3742. Epub 2014 Oct 17. Link to article on publisher's site

Journal/Book/Conference Title

Nature reviews. Immunology

Related Resources

Link to Article in PubMed

PubMed ID