Title
Innate sensing of malaria parasites
UMMS Affiliation
Department of Medicine, Division of Infectious Diseases and Immunology
Publication Date
2014-11-01
Document Type
Article
Disciplines
Immunity | Immunology and Infectious Disease | Immunology of Infectious Disease | Infectious Disease | Parasitic Diseases | Pathogenic Microbiology
Abstract
Innate immune receptors have a key role in immune surveillance by sensing microorganisms and initiating protective immune responses. However, the innate immune system is a classic 'double-edged sword' that can overreact to pathogens, which can have deleterious effects and lead to clinical manifestations. Recent studies have unveiled the complexity of innate immune receptors that function as sensors of Plasmodium spp. in the vertebrate host. This Review highlights the cellular and molecular mechanisms by which Plasmodium infection is sensed by different families of innate immune receptors. We also discuss how these events mediate both host resistance to infection and the pathogenesis of malaria.
DOI of Published Version
10.1038/nri3742
Source
Nat Rev Immunol. 2014 Nov;14(11):744-57. doi: 10.1038/nri3742. Epub 2014 Oct 17. Link to article on publisher's site
Journal/Book/Conference Title
Nature reviews. Immunology
Related Resources
PubMed ID
25324127
Repository Citation
Gazzinelli, Ricardo T.; Kalantari, Parisa; Fitzgerald, Katherine A.; and Golenbock, Douglas T., "Innate sensing of malaria parasites" (2014). Infectious Diseases and Immunology Publications and Presentations. 161.
https://escholarship.umassmed.edu/infdis_pp/161