Role of Drosophila IKK gamma in a toll-independent antibacterial immune response
Department of Medicine, Division of Infectious Diseases and Immunology
Animals; Antigens, Bacterial; Drosophila; *Drosophila Proteins; Gene Expression Regulation; I-kappa B Kinase; Immunity, Natural; Insect Proteins; Membrane Glycoproteins; Protein-Serine-Threonine Kinases; *Receptors, Cell Surface; Signal Transduction; Toll-Like Receptors; Transcription Factors
Immunology and Infectious Disease
We have generated, by ethylmethane sulfonate mutagenesis, loss-of-function mutants in the Drosophila homolog of the mammalian I-kappa B kinase (IKK) complex component IKK gamma (also called NEMO). Our data show that Drosophila IKK gamma is required for the Relish-dependent immune induction of the genes encoding antibacterial peptides and for resistance to infections by Escherichia coli. However, it is not required for the Toll-DIF-dependent antifungal host defense. The results indicate distinct control mechanisms of the Rel-like transactivators DIF and Relish in the Drosophila innate immune response and show that Drosophila Toll does not signal through a IKK gamma-dependent signaling complex. Thus, in contrast to the vertebrate inflammatory response, IKK gamma is required for the activation of only one immune signaling pathway in Drosophila.
DOI of Published Version
Nat Immunol. 2000 Oct;1(4):342-7. Link to article on publisher's site
Rutschmann, Sophie; Jung, Alain C.; Zhou, Rui; Silverman, Neal S.; Hoffmann, Jules A.; and Ferrandon, Dominique, "Role of Drosophila IKK gamma in a toll-independent antibacterial immune response" (2001). Infectious Diseases and Immunology Publications and Presentations. 13.