Role of Drosophila IKK gamma in a toll-independent antibacterial immune response

UMMS Affiliation

Department of Medicine, Division of Infectious Diseases and Immunology

Publication Date


Document Type



Animals; Antigens, Bacterial; Drosophila; *Drosophila Proteins; Gene Expression Regulation; I-kappa B Kinase; Immunity, Natural; Insect Proteins; Membrane Glycoproteins; Protein-Serine-Threonine Kinases; *Receptors, Cell Surface; Signal Transduction; Toll-Like Receptors; Transcription Factors


Immunology and Infectious Disease


We have generated, by ethylmethane sulfonate mutagenesis, loss-of-function mutants in the Drosophila homolog of the mammalian I-kappa B kinase (IKK) complex component IKK gamma (also called NEMO). Our data show that Drosophila IKK gamma is required for the Relish-dependent immune induction of the genes encoding antibacterial peptides and for resistance to infections by Escherichia coli. However, it is not required for the Toll-DIF-dependent antifungal host defense. The results indicate distinct control mechanisms of the Rel-like transactivators DIF and Relish in the Drosophila innate immune response and show that Drosophila Toll does not signal through a IKK gamma-dependent signaling complex. Thus, in contrast to the vertebrate inflammatory response, IKK gamma is required for the activation of only one immune signaling pathway in Drosophila.

DOI of Published Version



Nat Immunol. 2000 Oct;1(4):342-7. Link to article on publisher's site

Journal/Book/Conference Title

Nature immunology

Related Resources

Link to Article in PubMed

PubMed ID