Sorting out Toll signals
Department of Medicine, Division of Infectious Diseases and Immunology
Adaptor Proteins, Signal Transducing; Animals; Humans; Membrane Glycoproteins; Membrane Lipids; Myeloid Differentiation Factor 88; Phosphatidylinositol 4,5-Diphosphate; Phospholipids; Protein Transport; Receptors, Interleukin-1; Signal Transduction; Toll-Like Receptor 4; Toll-Like Receptors
Immunology and Infectious Disease
Upon recognition of microbial products, Toll-like receptors (TLRs) recruit distinct combinations of adaptors to induce TLR-specific gene expression. In this issue, Kagan and Medzhitov (2006) demonstrate that the adaptor TIRAP/Mal localizes to the plasma membrane by binding to phosphatidylinositol 4,5-bisphosphate (PIP2). This binding recruits a key adaptor MyD88 to TLR4, suggesting that there is crosstalk between the TLR signaling pathway and phospholipid metabolism.
DOI of Published Version
Cell. 2006 Jun 2;125(5):834-6. Link to article on publisher's site
Fitzgerald KA, Chen ZJ. (2006). Sorting out Toll signals. Infectious Diseases and Immunology Publications. https://doi.org/10.1016/j.cell.2006.05.014. Retrieved from https://escholarship.umassmed.edu/infdis_pp/125