TLR-mediated activation of type I IFN during antiviral immune responses: fighting the battle to win the war

UMMS Affiliation

Department of Medicine, Division of Infectious Diseases and Immunology

Publication Date


Document Type



Animals; Humans; Interferon Regulatory Factors; Interferon Type I; Toll-Like Receptors; Virus Diseases


Immunology and Infectious Disease


Toll-like receptors (TLRs) are crucially important in the sensing of viral infections and viral nucleic acids. TLR triggering leads to the induction of specific intracellular signaling cascades that result in the activation of two major families of transcription factors; the IFN-regulatory factors (IRFs) and nuclear factor-kappa B (NF-kappaB). IRFs and NF-kappaB work together to trigger the production of type I interferons (IFNalpha/beta) or inflammatory cytokines leading to the maturation of dendritic cells and the establishment of antiviral immunity. This review will focus on the most recent findings relating to the regulation of IRF activity by TLRs, highlighting the increasing complexity of TLR-mediated signaling pathways.

DOI of Published Version



Curr Top Microbiol Immunol. 2007;316:167-92. DOI: 10.1007/978-3-540-71329-6

Journal/Book/Conference Title

Current topics in microbiology and immunology

Related Resources

Link to Article in PubMed

PubMed ID