UMass Chan Affiliations
Department of Medicine, Division of Infectious Diseases and ImmunologyDocument Type
Journal ArticlePublication Date
2010-09-29Keywords
AnimalsCaspase 1
DNA, Viral
Enzyme Activation
Humans
*Immunity
Inflammasomes
Interferons
Interleukin-18
Interleukin-1beta
Nuclear Proteins
RNA, Double-Stranded
Receptors, Pattern Recognition
Virus Diseases
Immunology and Infectious Disease
Metadata
Show full item recordAbstract
Type I Interferons are the hallmark cytokines deployed during infection to combat invading viruses. However, inflammatory cytokines such as Interleukin (IL)-1beta and IL-18 also play important roles in anti-viral defenses. The activity of IL-1beta and IL18 are regulated at the level of expression, processing, and secretion. Several classes of innate immune receptors control the expression of these cytokines, which must then be proteolytically processed via caspase-1. In this review, we provide an overview of how caspase-1-activating inflammasomes participate during viral infections and their role in regulating anti-viral immunity.Source
J Clin Immunol. 2010 Sep;30(5):632-7. Epub 2010 Jul 28. Link to article on publisher's siteDOI
10.1007/s10875-010-9431-4Permanent Link to this Item
http://hdl.handle.net/20.500.14038/34888PubMed ID
20665097Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1007/s10875-010-9431-4