UMMS Affiliation

Department of Medicine, Division of Infectious Diseases and Immunology

Publication Date


Document Type



Insects; NF-kappa B; Phylogeny; Signal Transduction


Immunity | Molecular Biology


In this review, we discuss recent advances in understanding the signaling pathways in mammalian and Drosophila innate immunity, with emphasis on the mechanisms by which NF-kappaB/Rel family proteins are activated.


innate immunity, signaling pathways, Drosophila, NF-kappaB

Rights and Permissions

Publisher PDF posted as allowed by the publisher's author rights policy at Beginning six months from the full-issue publication date, articles published in Genes & Development that are not designated as Open Access are distributed under the Creative Commons Attribution-Non-Commercial 4.0 International License (CC-BY-NC), as described at This license permits non-commercial use, including reproduction, adaptation, and distribution of the article provided the original author and source are credited.

DOI of Published Version



Genes Dev. 2001 Sep 15;15(18):2321-42. Link to article on publisher's site

Journal/Book/Conference Title

Genes and development


At the time of publication, Neal Silverman was not yet affiliated with the University of Massachusetts Medical School.

Related Resources

Link to Article in PubMed

PubMed ID


Creative Commons License

Creative Commons Attribution-Noncommercial 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License



To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.