Comparison of putative intermediate phenotypes in schizophrenia patients with and without obsessive-compulsive disorder: examining evidence for the schizo-obsessive subtype
Department of Psychiatry; Shriver Center; Center for Health Policy and Research
Adult; Cognition Disorders; Craniofacial Abnormalities; Diagnostic and Statistical Manual of Mental Disorders; Female; Humans; Male; Middle Aged; Obsessive-Compulsive Disorder; *Phenotype; Psychotic Disorders; Schizophrenia; *Schizophrenic Psychology
Psychiatry | Psychiatry and Psychology
Obsessive-compulsive symptoms or obsessive-compulsive disorder (OCD) is estimated to occur in up to 30% of patients with schizophrenia. Whether this subgroup of patients is cognitively, affectively, or physiologically distinct remains unclear. 204 schizophrenia patients, 15 who also met criteria for a diagnosis of OCD, and 147 healthy controls were examined on several intermediate phenotypes. The patient groups did not differ from each other except that the co-morbid group exhibited an elevated rate of eye-tracking dysfunction. Results suggest that OCD-co-morbid patients did not comprise a distinct subgroup based on the measures studied here, although systematic assessment of larger cohorts is warranted.
DOI of Published Version
Schizophr Res. 2012 Sep;140(1-3):83-6. doi: 10.1016/j.schres.2012.06.033. Link to article on publisher's site
Docherty AR, Coleman MJ, Tu X, Deutsch CK, Mendell NR, Levy DL. (2012). Comparison of putative intermediate phenotypes in schizophrenia patients with and without obsessive-compulsive disorder: examining evidence for the schizo-obsessive subtype. Center for Health Policy and Research (CHPR) Publications. https://doi.org/10.1016/j.schres.2012.06.033. Retrieved from https://escholarship.umassmed.edu/healthpolicy_pp/99