Chromatin remodeling: a marriage between two families
Graduate School of Biomedical Sciences; Graduate School of Biomedical Sciences; Department of Biochemistry and Molecular Biology; Program in Molecular Medicine
Life Sciences | Medicine and Health Sciences
The compaction of the eukaryotic genome into a highly folded chromatin structure necessitates cellular mechanisms for allowing access of regulatory proteins to the DNA template. Recent advances in the fields of gene silencing, transcription, recombination, and DNA repair have led to the identification of two distinct families of chromatin remodeling enzymes--nuclear histone acetyltransferases and multisubunit complexes that harbor a SWI2/SNF2 ATPase family member. This paper reviews the current notion of how these enzymes function in remodeling chromatin; we then discuss some tantalizing lines of evidence that lead to the hypothesis that members of both families may actually function in concert to facilitate cellular processes in the context of chromatin.
DOI of Published Version
Bioessays. 1998 Sep;20(9):771-80. Link to article on publisher's site
BioEssays : news and reviews in molecular, cellular and developmental biology
Pollard KJ, Peterson CL. (1998). Chromatin remodeling: a marriage between two families. GSBS Student Publications. https://doi.org/10.1002/(SICI)1521-1878(199809)20:9<771::AID-BIES10>3.0.CO;2-V. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/995