GSBS Student Publications

Title

Chromatin remodeling: a marriage between two families

Publication Date

1998-11-20

UMMS Affiliation

Graduate School of Biomedical Sciences; Graduate School of Biomedical Sciences; Department of Biochemistry and Molecular Biology; Program in Molecular Medicine

Document Type

Article

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

The compaction of the eukaryotic genome into a highly folded chromatin structure necessitates cellular mechanisms for allowing access of regulatory proteins to the DNA template. Recent advances in the fields of gene silencing, transcription, recombination, and DNA repair have led to the identification of two distinct families of chromatin remodeling enzymes--nuclear histone acetyltransferases and multisubunit complexes that harbor a SWI2/SNF2 ATPase family member. This paper reviews the current notion of how these enzymes function in remodeling chromatin; we then discuss some tantalizing lines of evidence that lead to the hypothesis that members of both families may actually function in concert to facilitate cellular processes in the context of chromatin.

DOI of Published Version

10.1002/(SICI)1521-1878(199809)20:9<771::AID-BIES10>3.0.CO;2-V

Source

Bioessays. 1998 Sep;20(9):771-80. Link to article on publisher's site

Journal/Book/Conference Title

BioEssays : news and reviews in molecular, cellular and developmental biology

Related Resources

Link to article in PubMed

PubMed ID

9819566

Share

COinS