Title
BLyS and B cell homeostasis
UMMS Affiliation
Graduate School of Biomedical Sciences; Department of Molecular Genetics and Microbiology; Department of Physiology
Publication Date
2006-08-26
Document Type
Article
Disciplines
Life Sciences | Medicine and Health Sciences
Abstract
Naive peripheral B cells survive in vivo because of active stimulation by the TNF superfamily ligand B lymphocyte stimulator (BLyS/BAFF). Although the survival promoting properties of BLyS are well known, the signal pathways and molecular effectors that characterize this stimulation are still being elucidated. In this communication, we discuss the signal cascades that effect BLyS dependent survival and the regulation of BLyS induced signaling. We also examine the role of BLyS as a growth factor and propose that BLyS induced metabolic enhancement optimizes the B cell response to BCR and TLR-dependent signaling.
DOI of Published Version
10.1016/j.smim.2006.06.001
Source
Semin Immunol. 2006 Oct;18(5):318-26. Epub 2006 Aug 22. Link to article on publisher's site
Journal/Book/Conference Title
Seminars in immunology
Related Resources
PubMed ID
16931037
Repository Citation
Woodland RT, Schmidt MR, Thompson CB. (2006). BLyS and B cell homeostasis. GSBS Student Publications. https://doi.org/10.1016/j.smim.2006.06.001. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/944