Title
Arachidonic acid and other fatty acids directly activate potassium channels in smooth muscle cells
Academic Program
Biochemistry & Molecular Pharmacology
UMMS Affiliation
Graduate School of Biomedical Sciences; Department of Physiology
Publication Date
1989-06-09
Document Type
Article
Disciplines
Life Sciences | Medicine and Health Sciences
Abstract
Arachidonic acid, as well as fatty acids that are not substrates for cyclooxygenase and lipoxygenase enzymes, activated a specific type of potassium channel in freshly dissociated smooth muscle cells. Activation occurred in excised membrane patches in the absence of calcium and all nucleotides. Therefore signal transduction pathways that require such soluble factors, including the NADPH-dependent cytochrome P450 pathway, do not mediate the response. Thus, fatty acids directly activate potassium channels and so may constitute a class of signal molecules that regulate ion channels.
DOI of Published Version
10.1126/science.2471269
Source
Science. 1989 Jun 9;244(4909):1176-9.
Journal/Book/Conference Title
Science (New York, N.Y.)
Related Resources
PubMed ID
2471269
Repository Citation
Ordway RW, Walsh JV, Singer JJ. (1989). Arachidonic acid and other fatty acids directly activate potassium channels in smooth muscle cells. GSBS Student Publications. https://doi.org/10.1126/science.2471269. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/924