Title
Complex T cell memory repertoires participate in recall responses at extremes of antigenic load
Academic Program
Biochemistry & Molecular Pharmacology
UMMS Affiliation
Department of Pathology
Publication Date
2006-08-01
Document Type
Article
Disciplines
Immunology and Infectious Disease | Life Sciences | Medicine and Health Sciences
Abstract
The CD8 T cell memory response to the HLA-A2-restricted influenza epitope M1(58-66) can be an instructive model of immune memory to a nonevolving epitope of a frequently encountered pathogen that undergoes clearance. This memory repertoire can be complex, composed of a large number of clonotypes represented at low copy numbers, while maintaining a focus on the use of VB17 T cell receptors with identified Ag recognition motifs. Such a repertoire structure might provide a panoply of clonotypes whose differential avidity for the epitope would allow responses under varying antigenic loads. This possibility was tested experimentally by characterizing the responding repertoire in vitro while varying influenza Ag concentration over five orders of magnitude. At higher and lower Ag concentrations there was increased cell death, yet a focused but diverse response could still be observed. Thus, one of the characteristics of complex memory repertoires is to provide effector function at extremes of Ag load, a characteristic that is not generally considered in vaccination development but may be important in measuring its efficacy.
DOI of Published Version
10.4049/jimmunol.177.3.2006
Source
J Immunol. 2006 Aug 1;177(3):2006-14.
Journal/Book/Conference Title
Journal of immunology (Baltimore, Md. : 1950)
Related Resources
PubMed ID
16849515
Repository Citation
Naumov YN, Naumova EN, Clute SC, Watkin LB, Kota K, Gorski JP, Selin LK. (2006). Complex T cell memory repertoires participate in recall responses at extremes of antigenic load. GSBS Student Publications. https://doi.org/10.4049/jimmunol.177.3.2006. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/900