Title
Molecular events that regulate alphabeta versus gammadelta T cell lineage commitment: old suspects, new players and different game plans
UMMS Affiliation
Graduate School of Biomedical Sciences; Department of Pathology
Publication Date
2007-02-13
Document Type
Article
Disciplines
Life Sciences | Medicine and Health Sciences
Abstract
The divergence of alphabeta and gammadelta T cells from a common precursor in the thymus is regulated by multiple cell-intrinsic and cell-extrinsic factors, most of which are not well defined. Recent studies have provided crucial data regarding the precise timing of lineage commitment and some clarification on the extent of the involvement of Notch and T-cell receptor signaling in this process. Combined with new insights into the differential regulation of molecular pathways active in alphabeta and gammadelta precursors, these data have led to the generation of a revised model of lineage commitment.
DOI of Published Version
10.1016/j.coi.2007.01.002
Source
Curr Opin Immunol. 2007 Apr;19(2):169-75. Epub 2007 Feb 8. Link to article on publisher's site
Journal/Book/Conference Title
Current opinion in immunology
Related Resources
PubMed ID
17291740
Repository Citation
Narayan K, Kang J. (2007). Molecular events that regulate alphabeta versus gammadelta T cell lineage commitment: old suspects, new players and different game plans. GSBS Student Publications. https://doi.org/10.1016/j.coi.2007.01.002. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/897